Results 21 to 30 of about 291,090 (273)

Systems immunology. [PDF]

Curr Opin Immunol, 2020
Systems biological approaches to immunology have grown exponentially in the past decade, especially as broad approaches to data collection have become more accessible. It is still in its infancy; however, largely descriptive, and looking for the main drivers of particular phenomena, such as vaccination effects or pregnancy.
Davis MM.
europepmc   +3 more sources

Decoding sex differences in human immunity through systems immunology. [PDF]

Oxf Open Immunol
Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and prevalence of ...
Escrivà-Font J, Cao T, Consiglio CR.
europepmc   +2 more sources

A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

Frontiers in Immunology, 2023
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability to mediate inflammatory responses of the immune system. Given the critical role of DCs in shaping immunity, they present an attractive avenue as a therapeutic ...
Sara Sadat Aghamiri, Bhanwar Lal Puniya, Rada Amin, Tomáš Helikar   +3 more
doaj   +1 more source

Progress in kidney transplantation: The role for systems immunology. [PDF]

Front Med (Lausanne), 2022
The development of systems biology represents an immense breakthrough in our ability to perform translational research and deliver personalized and precision medicine.
Johnson AC, Silva JAF, Kim SC, Larsen CP.   +3 more
europepmc   +2 more sources

Immune network operations in COVID-19

Exploration of Immunology, 2022
The immune system, whose nature lies in being a complex network of interactions, lends itself well to being represented and studied using graph theory.
Javier Burgos-Salcedo
doaj   +1 more source

Identification of unique immune response expression profiles to SARS-CoV-2 in non-small cell lung cancer using systems immunology approach

Advances in Biomedical and Health Sciences, 2022
Background: COVID-19 severity and mortality are higher in patients with lung cancer due to pulmonary complications. Understanding the mechanisms of SARS-COV-2 effect on lung cancer cells in comparison to healthy lung cells can improve our knowledge of ...
Saba Al Heialy, Mahmood Yaseen Hachim, Ibrahim Yaseen Hachim, Rifat Hamoudi, Qutayba Hamid   +4 more
doaj   +1 more source

Use of Mass Cytometry to Profile Human T Cell Exhaustion

Frontiers in Immunology, 2020
Mass cytometry has become an important technique for the deep analysis of single cell protein expression required for precision systems immunology. The ability to profile more than 40 markers per cell is particularly relevant for the differentiation of ...
Frances Winkler, Frances Winkler, Bertram Bengsch, Bertram Bengsch   +3 more
doaj   +1 more source

The Role of Systems Vaccinology in Understanding the Immune Defects to Vaccination in Solid Organ Transplant Recipients

Frontiers in Immunology, 2020
Solid organ transplant recipients (SOTRs) are at increased risk for many infections, whether viral, bacterial, or fungal, due to immunosuppressive therapy to prevent organ rejection.
Nicholas Scanlon, Nicholas Scanlon, Youssef Saklawi, Nadine Rouphael, Nadine Rouphael   +4 more
doaj   +1 more source

Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Human Vaccines & Immunotherapeutics, 2023
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors.
Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A. Kutzler, Roshell Muir, Elias K. Haddad   +11 more
doaj   +1 more source

Immunology and the Central Nervous System [PDF]

Clinical and Developmental Immunology, 2013
We are pleased to announce the publication of this special issue in the journal “Clinical and Developmental Immunology.” We are happy to perceive the growing interest, from a wide range of scientists, regarding the peculiar intercommunication between the immune system and the central nervous system (CNS).
Carlos Barcia, James Curtin, Jeffrey Zirger, Daniel Larocque   +3 more
openaire   +4 more sources