Results 101 to 110 of about 3,975,199 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Telecoupling Toolbox: spatially explicit tools for studying telecoupled human and natural systems
Ecology and Society, 2017 Telecoupling is a novel interdisciplinary umbrella concept that enables natural and social scientists to understand and generate information for managing how humans and nature can sustainably coexist worldwide.
Francesco Tonini, Jianguo Liu
doaj +1 more source
Adaptive service discovery on service-oriented and spontaneous sensor systems [PDF]
, 2012 Service-oriented architecture, Spontaneous networks, Self-organisation, Self-configuration, Sensor systems, Social patternsNatural and man-made disasters can significantly impact both people and environments.
Antonopoulos, Nikolaos +4 more
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Process and information integration via hypermedia [PDF]
Success stories for advanced automation prototypes abound in the literature but the deployments of practical large systems are few in number. There are several factors that militate against the maturation of such prototypes into products.
Hammen, David G. +2 more
core +1 more source
Neurons and symbols: a manifesto [PDF]
, 2010 We discuss the purpose of neural-symbolic integration including its principles, mechanisms and applications. We outline a cognitive computational model for neural-symbolic integration, position the model in the broader context of multi-agent systems ...
Garcez, A.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Heterogeneous Autonomous Robotic System in Viticulture and Mariculture: Vehicles Development and Systems Integration. [PDF]
Sensors (Basel), 2022 Kapetanović N +10 more
europepmc +1 more source
Perturbed and Permuted: Signal Integration in Network-Structured Dynamic Systems [PDF]
, 2011 Biological systems (among others) may respond to a large variety of distinct external stimuli, or signals. These perturbations will generally be presented to the system not singly, but in various combinations, so that a proper understanding of the system
Wylie, Dennis
core