Results 181 to 190 of about 29,218,428 (332)

Techno-economic analysis for a 100% renewable hybrid energy systems integration in a research facility in Morocco. [PDF]

iScience
Choukri NE, Touili S, Azzaoui A, Alami Merrouni A.   +3 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Potential benefits and human systems integration of parastronauts with bilateral vestibulopathy for a space mission. [PDF]

Front Neurol
Ramsburg CF, Wood SJ, Lackner JR, Moynihan S, Reschke MF, Denise P, Clément G.   +6 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Public Health Workforce Professional Development Analysis: A Human-Systems Integration for Healthy Communities. [PDF]

Int J Public Health
Osnat B, Orna BE, Tomasz B, Kasia C, Nadav D, Jascha N, Keren D, Mariusz D, Janas H, Lore L, Hagai L, Fiona M, Maureen M, Zohar M, Yehuda N, Leah OE, Robert O, Stephanie PB, Maya PR, Theodore T, Shira ZS, Paul B.   +21 more
europepmc   +1 more source

Highlights from the First Annual Spinal Navigation, Emerging Technologies and Systems Integration Meeting. [PDF]

Ann Transl Med, 2018
Drazin D, Grunert P, Hartl R, Polly D, Meyer B, Catchpole K, Laufer I, Sethi R, Perry T, Simon D, Wang M, Fisher C, Scribner M, White G, Tubbs RS, Oskouian RJ, Kim T, Johnson JP.   +17 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Achieving COVID-19 and Routine Immunization Data Systems Integration on the Electronic Management of Immunization Data System in Nigeria. [PDF]

Glob Health Sci Pract
Tella-Lah T, Akinleye D, Aliyu AS, Falodun T, Okpere S, Akpan D, Orefunwa O, Metiboba L, Owoicho J, Okposen B, Nwabufo A.   +10 more
europepmc   +1 more source

Clinical Information Systems Integration in New York City's First Mobile Stroke Unit. [PDF]

Appl Clin Inform, 2018
Kummer BR, Lerario MP, Navi BB, Ganzman AC, Ribaudo D, Mir SA, Pishanidar S, Lekic T, Williams O, Kamel H, Marshall RS, Hripcsak G, Elkind MSV, Fink ME.   +13 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source