Results 81 to 90 of about 3,975,199 (305)
Integration between Primary Health Care and Emergency Services in Brazil: Barriers and Facilitators
International Journal of Integrated Care, 2018 Introduction: Characteristics of primary health care and emergency services may hamper their integration and, therefore, reduce the quality of care and the effectiveness of health systems.
Liza Yurie Teruya Uchimura +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Avionics systems integration technology [PDF]
A very dramatic and continuing explosion in digital electronics technology has been taking place in the last decade. The prudent and timely application of this technology will provide Army aviation the capability to prevail against a numerically superior
Stech, George, Williams, James R.
core +1 more source
Patterns of information security postures for socio-technical systems and systems-of-systems [PDF]
, 2012 This paper describes a proposal to develop patterns of security postures for computer based socio-technical systems and systems-of-systems.
Glisson, W., Renaud, K., Storer, T.
core
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Ontological theory for ontological engineering: Biomedical systems information integration [PDF]
, 2004 Software application ontologies have the potential to become the keystone in state-of-the-art information management techniques. It is expected that these ontologies will support the sort of reasoning power required to navigate large and complex ...
Ceusters, Werner +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Production, 2008 Este trabalho apresenta uma metodologia de projeto aplicada a sistemas automatizados e integrados de manufatura. A metodologia consiste em um desenvolvimento cíclico de três etapas - modelagem, síntese e implementação - até o atendimento da aplicação ...
Marco Antonio Busetti de Paula +1 more
doaj +1 more source