Results 101 to 110 of about 1,991,043 (280)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Emergency Medical Services Clinicians and COVID-19 Booster Behavior—A Cross-Sectional National Evaluation

Vaccines
Background/Objectives: Emergency Medical Services (EMS) clinicians in the US have high COVID-19 vaccine hesitancy rates and often do not receive primary vaccinations or subsequent boosters.
Gregory Muller, Christopher B. Gage, Jonathan R. Powell, Sarah R. MacEwan, Laura J. Rush, Eben Kenah, Gennaro Di Tosto, Ann Scheck McAlearney, Ashish R. Panchal   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patient portal messaging for care coordination: a qualitative study of perspectives of experienced users with chronic conditions

BMC Family Practice, 2019
Background Patient portal secure messaging (asynchronous electronic communication between physicians and their established patients) allows patients to manage their care through asynchronous, direct communication with their providers.
Jennifer L. Hefner, Sarah R. MacEwan, Alison Biltz, Cynthia J. Sieck   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Predicting Individual Systems Thinking Skills Using Bayesian Network Approach

IEEE Access
Emergence in complex systems is often compounded by diverse information and rapid technological acceleration. The problems and behaviors of increasingly complex systems continue confining practitioners’ systems engineering capabilities to maintain
Niamat Ullah Ibne Hossain, Raed Jaradat, Morteza Nagahi, Alex Gorod   +3 more
doaj   +1 more source

If you're a fish, what can you know about the water? [PDF]

, 2001
The authors of this paper have been engaged in Systems Thinking, Systems Practice and Systems Teaching for many years. In this paper they reflect on their experience of engaging systemically with their own organisation in order to bring about change.
Armson, Rosalind, Ison, Ray
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

On the design of systems-oriented university curricula

, 2009
This paper proposes a tool called the Systems Education Matrix (SEM) for use in informing the work of developers of systems-oriented curricula at colleges and universities around the world.
Bosch, Ockie, Drack, Manfred, Horiuchi, Yoshihide, Jones, Jed, Ramage, Magnus   +4 more
core  

Communicating about systems and complexity:from contingency to praxis [PDF]

, 2015
The chapter is part of a special Gedenkschrift publication honoring the work of Professsor Brenda Zimmerman in the field of complexity thinking. The term, Gedenkschrift, borrowed from German, can be translated as celebration publication.
Reynolds, Martin
core