Results 131 to 140 of about 1,991,043 (280)
Equity-focused developmental evaluation using critical systems thinking [PDF]
, 2012 Developmental evaluation questions the ethical basis of an intervention in terms of whether it’s ‘doing the right thing’ rather than merely ‘doing things right’.
Reynolds, Martin
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Systems thinking for design thinking. [PDF]
, 2015 This article seeks to contribute to a discussion which could propitiate, in my opinion, the emergence of interesting connections between the Systemic Design field, German media theory, and the work of Bruno Latour on Science and Technology Studies (STS).
Darzentas, Jenny, Darzentas, John
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Systems practice in engineering: reflections on doctoral level systems supervision [PDF]
, 2011 The Industrial Doctorate Centre (IDC) in Systems, a collaboration between the University of Bristol and the University of Bath, offers an Engineering Doctorate (EngD) in Systems Programme which is aimed at high-calibre engineers from graduate level to ...
Yearworth, M
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Social and Ecological Responsibility: A Critical Systemic Perspective [PDF]
, 2003 The notion of systemic thinking for social and ecological responsibility is deconstructed and its holistic potential examined from a critical systemic perspective informed by the ideas of the systems philosopher, C. West-Churchman.
Reynolds, Martin
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Gender-Inclusive Library Workgroup Report [PDF]
, 2018 The Gender-Inclusive Workgroup explored how VCU Libraries can better serve trans and gender-nonconforming users and staff. The group’s recommendations cover library spaces, staff, systems, services, and culture.
Barkley, Steve +4 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source