Results 201 to 210 of about 102,232 (247)
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Journal of the American Oil Chemists' Society, EarlyView.ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak +4 more
wiley +1 more source
Green toxicology only becomes beautiful through AI. [PDF]
Front ChemMaertens A, Hartung T.
europepmc +1 more source
Sustainable Manufacturing Platforms for Closed‐Cycle Bioeconomy Applications
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT The transition to a circular bioeconomy requires innovative production platforms that prioritize sustainability, resource efficiency, and waste minimization. Organic waste from agriculture, aquaculture, and food production represents an underutilized feedstock for biomanufacturing, contributing to a circular economy.
Yelizaveta Chernysh +2 more
wiley +1 more source
Rethinking "Control" in Micro- and Nanoplastic Toxicology: Toward Exposure-Defined Reference States. [PDF]
Environ Sci TechnolShruti VC, Kutralam-Muniasamy G.
europepmc +1 more source
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Expert Review of Proteomics, 2005
Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology enables the study of adverse effects of xenobiotic substances in relation to structure and activity of the ...
Ben Van Ommen +2 more
exaly +4 more sources
Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology enables the study of adverse effects of xenobiotic substances in relation to structure and activity of the ...
Ben Van Ommen +2 more
exaly +4 more sources
Toward an integrative systems toxicology
Pharmacogenomics, 200410.1517/14622416.5.8.1163 © Assessing toxicity is among the most ancient and important of human endeavors. Long before the taming of fire or the advent of tool use, humankind was confronted with a most basic problem of existence: what to ingest. Today, toxicology impacts every facet of our lives – from the food, supplements and therapeutics that we ...
Patrick Hurban
exaly +3 more sources
Proteomics in systems toxicology
2021Proteins are the ultimate product of gene expression. As they hinge between gene transcription and phenotype, they offer a more realistic perspective of toxicopathic effects, responses and even susceptibility to insult than targeting genes and mRNAs while dodging some inter-individual variability that hinders measuring downstream endpoints like ...
Carolina, Madeira, Pedro M, Costa
openaire +2 more sources
2021
Systems toxicology, a branch of toxicology that studies chemical effects on biological systems, presents exciting knowledge discovery challenges for the information researcher. The exponential increase in availability of genomic and proteomic data in this domain needs to be matched with increasingly sophisticated network analysis approaches.
Kaushal D. Desai, Xiaohua Hu
openaire +1 more source
Systems toxicology, a branch of toxicology that studies chemical effects on biological systems, presents exciting knowledge discovery challenges for the information researcher. The exponential increase in availability of genomic and proteomic data in this domain needs to be matched with increasingly sophisticated network analysis approaches.
Kaushal D. Desai, Xiaohua Hu
openaire +1 more source