Results 181 to 190 of about 102,232 (247)

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury. [PDF]

Toxicol Sci, 2019
Longo DM, Woodhead JL, Walker P, Herédi-Szabó K, Mogyorósi K, Wolenski FS, Dragan YP, Mosedale M, Siler SQ, Watkins PB, Howell BA.   +10 more
europepmc   +1 more source

Local Construction Employment and Binge Drinking Among US Adults in Their Early 30s: Insights From a Path Analysis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Objective Construction workers face elevated risks of alcohol misuse—especially binge drinking—due to physically demanding labor, long hours, and limited paid vacation. At the same time, emerging evidence suggests that a larger local construction sector may have protective community‐level effects on alcohol and other drug outcomes.
Sehun Oh, Bridget Freisthler, Devan Hawkins   +2 more
wiley   +1 more source

Federal Protections for Farmworker Health in the United States: A Scoping Review of Three Decades of Research

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Objectives This scoping review characterizes the scope, methods, and framing of empirical research evaluating the Field Sanitation Standard (FSS) and Worker Protection Standard (WPS) of the U.S. Environmental Protection Agency and the U.S. Department of Labor respectively.
Kaitlyn Alvarez Noli, Stephane Labossiere, Becca Berkey, Joseph G. Grzywacz   +3 more
wiley   +1 more source

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment. [PDF]

Intern Emerg Med, 2019
Iskandar AR, Zanetti F, Kondylis A, Martin F, Leroy P, Majeed S, Steiner S, Xiang Y, Ortega Torres L, Trivedi K, Guedj E, Merg C, Frentzel S, Ivanov NV, Doshi U, Lee KM, McKinney WJ, Peitsch MC, Hoeng J.   +18 more
europepmc   +1 more source

Cognitive Performance in Young Adults During Three Consecutive Days of Simulated Occupational Heat Stress: An Exploratory Study

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Global increases in occupational heat exposure are raising concerns about worker safety and cognitive performance during prolonged and repeated shifts. At present, the cumulative effects of repeated heat exposure on cognitive performance remain unclear.
Daniel C. Moore, Sean R. Notley, Brad Aisbett, Jarrad Lum, Luana C. Main   +4 more
wiley   +1 more source

Iron overload by Superparamagnetic Iron Oxide Nanoparticles is a High Risk Factor in Cirrhosis by a Systems Toxicology Assessment. [PDF]

Sci Rep, 2016
Wei Y, Zhao M, Yang F, Mao Y, Xie H, Zhou Q.   +5 more
europepmc   +1 more source

Cancer Incidence Among Swedish Seafarers Between 1985 and 2020

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Several studies from different countries have shown that merchant seafarers have an increased cancer risk compared to the general population. The aim of this study was to provide updated information on cancer incidence in a cohort of Swedish seafarers.
Maria Wallin, Helena P. Eriksson, Karl Forsell, Eva Andersson   +3 more
wiley   +1 more source

Systems toxicology of chemically induced liver and kidney injuries: histopathology-associated gene co-expression modules. [PDF]

J Appl Toxicol, 2016
Te JA, AbdulHameed MD, Wallqvist A.
europepmc   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source