Results 171 to 180 of about 108,508 (278)

Quantitative Systems Toxicology Predicts Ivacaftor-Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity. [PDF]

Clin Pharmacol Ther
Shi A, Cornwell C, Yang K, Beringer PM.
europepmc   +1 more source

Nanodiamonds as Bioactive Platforms to Modulate Microbial, Mammalian, and Vertebrate Systems

Advanced NanoBiomed Research, EarlyView.
Nanodiamonds (NDs) are biocompatible and antibacterial nanomaterials that support mammalian cell growth while inhibiting bacterial pathogens. NDs showed strong antibacterial activity, with Escherichia coli being more sensitive than Staphylococcus aureus. At 10 mg/mL, both bacteria exhibited ~8% viability.
Aaqil Rifai, Ayushi Priyam, Ahmed Rashed, Gebreselassie Addisu Tilaye, Kamal Poudel, Aaron G. Schultz, Richard J. Williams   +6 more
wiley   +1 more source

Nervous System Toxicology [PDF]

Journal of Neuropathology and Experimental Neurology, 1983
openaire   +2 more sources

A systems toxicology approach implicates post-transcriptional regulatory networks in reproductive defects from PFAS exposure. [PDF]

Toxicol Sci
Bline AP, Jiang H, Levenson M, Allard P.
europepmc   +1 more source

Mitigating Trastuzumab-Doxorubicin Cardiotoxicity With Multiscale Quantitative Systems Toxicology and PBPK-Toxicodynamic Predictive Modeling Framework. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yu S, Mody H, Vaidya TR, Kagan L, Ait-Oudhia S.   +4 more
europepmc   +1 more source

Systems Toxicology Approach to Identifying Paracetamol Overdose. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2018
Mason CL, Leedale J, Tasoulis S, Jarman I, Antoine DJ, Webb SD.   +5 more
europepmc   +1 more source

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke. [PDF]

Comput Struct Biotechnol J, 2020
Titz B, Szostak J, Sewer A, Phillips B, Nury C, Schneider T, Dijon S, Lavrynenko O, Elamin A, Guedj E, Tsin Wong E, Lebrun S, Vuillaume G, Kondylis A, Gubian S, Cano S, Leroy P, Keppler B, Ivanov NV, Vanscheeuwijck P, Martin F, Peitsch MC, Hoeng J.   +22 more
europepmc   +1 more source

Autoimmune models

, 2010
Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a ...
Cauvi, DM,, Pollard, KM,, Hultman, Per,
core  

RENAsym, a quantitative systems toxicology platform model, designed to predict drug-induced kidney injury indicates polymyxin B and valproate overdose toxicity potential while simultaneously demonstrating acetaminophen and valproate safety at therapeutic levels. [PDF]

Toxicol Sci
Vallejo C, Bhargava P, Hamzavi N, McDaniel M, Lakhani VV, Qi T, Battista C, Clemens L, Shoda LKM, Kenz ZR, Tallapaka S, Gebremichael Y, Woodhead JL.   +12 more
europepmc   +1 more source

A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro. [PDF]

Toxicol Sci, 2019
Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS.   +10 more
europepmc   +1 more source