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Toxicology and Applied Pharmacology, 2011 Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, e.g., transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology measures to improve the understanding of mechanisms of hepatotoxic ...
Anne S Kienhuis +2 more
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Proteomics in systems toxicology
2021Proteins are the ultimate product of gene expression. As they hinge between gene transcription and phenotype, they offer a more realistic perspective of toxicopathic effects, responses and even susceptibility to insult than targeting genes and mRNAs while dodging some inter-individual variability that hinders measuring downstream endpoints like ...
Carolina, Madeira, Pedro M, Costa
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2021
Systems toxicology, a branch of toxicology that studies chemical effects on biological systems, presents exciting knowledge discovery challenges for the information researcher. The exponential increase in availability of genomic and proteomic data in this domain needs to be matched with increasingly sophisticated network analysis approaches.
Kaushal D. Desai, Xiaohua Hu
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Systems toxicology, a branch of toxicology that studies chemical effects on biological systems, presents exciting knowledge discovery challenges for the information researcher. The exponential increase in availability of genomic and proteomic data in this domain needs to be matched with increasingly sophisticated network analysis approaches.
Kaushal D. Desai, Xiaohua Hu
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New Applications of Bacterial Systems to Problems in Toxicology
Critical Reviews in Toxicology, 1996 Bacterial systems have long been of use in toxicology. In addition to providing general models of enzymes and paradigms for biochemistry and molecular biology, they have been adapted to practical genotoxicity assays.
F Peter Guengerich +2 more
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Systems biology approaches for toxicology
Journal of Applied Toxicology, 2007AbstractSystems biology/toxicology involves the iterative and integrative study of perturbations by chemicals and other stressors of gene and protein expression that are linked firmly to toxicological outcome. In this review, the value of systems biology to enhance the understanding of complex biological processes such as neurodegeneration in the ...
William, Slikker +4 more
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Toxicology of Sensory Systems: A Perspective
Human & Experimental Toxicology, 1992This brief review is the result of a recent meeting of the British Toxicology Society (Toxicology of Sensory Systems, University of York, April 2-3, 1992). The meeting provided the opportunity to discuss the anatomy, physiology and function of the eye, ear, nasal epithelium and peripheral sensation and the methods that are available to detect injury or
E A, Lock, E S, Harpur
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Toxicology and the Immune System: a Perspective
Human & Experimental Toxicology, 1991The relationship of immunology to toxicology has not always been an easy one, and the product of this association, immunotoxicology, has not infrequently been viewed with a certain scepticism by some of those who consider themselves 'classical' toxicologists.
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1995
There is no shortage of toxic factors that have been proposed as aetiological agents in motor neuron disease. Of exogenous origin lead, mercury (elemental and organic) selenium and manganese are most cited (Tandan and Bradley 1985). The incidence of the amyotrophic lateral sclerosis (motor neuron disease)-parkinsonism-dementia complex (ALS-PD) of Guam ...
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There is no shortage of toxic factors that have been proposed as aetiological agents in motor neuron disease. Of exogenous origin lead, mercury (elemental and organic) selenium and manganese are most cited (Tandan and Bradley 1985). The incidence of the amyotrophic lateral sclerosis (motor neuron disease)-parkinsonism-dementia complex (ALS-PD) of Guam ...
openaire +1 more source