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Functions of Periostin in pre-metastatic immunosuppressive niches of breast tumor metastasis [PDF]
, 2016 在肿瘤发生发展过程中，肿瘤细胞及其相关间质细胞向肿瘤微环境中分泌大量促癌细胞因子以及趋化因子，促使骨髓来源的免疫抑制细胞（myeloid-derivedsuppressorcells，MDSCs）向远处靶器官浸润，形成免疫抑制微环境，为肿瘤细胞的转移提供有利条件，从而促进肿瘤细胞的转移。在乳腺癌肿瘤组织中，细胞外基质蛋白Periostin主要由肿瘤相关成纤维细胞分泌，并参与调控肿瘤的发生发展过程。然而，关于Periostin蛋白在MDSCs介导的转移前微环境形成中的功能尚不清楚 ...
熊珊珊
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Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的观察枸杞多糖对效应T细胞增殖和杀瘤活性机制的作用。方法通过密度梯度离心法分离人外周血单核细胞并培养其为树突状细胞,用冻融法制备肝癌细胞的全抗原并致敏树突状细胞;通过混合淋巴细胞实验,获取树突状细胞激活的特异性效应T细胞。用MTT法测定效应T细胞对肝癌细胞的杀伤率。观察枸杞多糖在树突状细胞的成熟及T细胞的激活、增殖和杀瘤过程中的作用。结果枸杞多糖单独对T细胞无明显的增殖能力,但能促进树突状细胞的成熟并且能增强效应T细胞的增殖能力和杀瘤活性 ...
王晓华 +3 more
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Thalidomide combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice [PDF]
, 2015 目的：体内预存的各种记忆细胞是器官移植中的重要障碍。记忆细胞对侵入的病原体产生强烈的免疫反应，但同时会导致移植物发生排斥。研究发现，沙利度胺在初次器官移植中具有抑制免疫排斥反应的作用，但其作用机制仍不明确。沙利度胺在器官移植中的潜在作用，很有可能使其成为作用于新靶点、高效低毒的免疫抑制剂。这里，我们拟研究沙利度胺联合共刺激分子阻断剂对皮肤预致敏小鼠心脏移植物生存期的作用，并探讨其在免疫记忆中的作用机制。 方法：首先通过同种异体皮肤移植得到预致敏小鼠，然后随机将皮肤预致敏小鼠分成4组，每组6只。对照组 ...
朱茂述
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的通过检测肺结核（TB）患者外周血淋巴细胞亚群的比例变化,来探讨其在结核病发展中的意义。方法用流式细胞仪分别检测原发型肺结核（Ⅰ型TB）组（15例）,血行播散型结核（Ⅱ型TB）组（15例）、正常对照组（25例）的外周血淋巴细胞表面标记:CD4、CD8、CD3、CD69、CD25、CD16+CD56、CD19。结果Ⅰ型结核病人的T细胞亚群的辅助性T细胞（Th）、细胞毒T细胞（Tc）、总T细胞的分布比例与正常对照无显著性差异,而活化的Th,Tc比例都比正常组高 ...
施华萍, 蔡龙, 周红娟
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pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells [PDF]
, 2013 目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf ...
丁园 +8 more
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2019 目的探究外周血T淋巴细胞亚群在不同致敏原因哮喘儿童中的表达,旨在为临床的诊断和治疗提供科学依据。方法选取2016年4月至2018年4月于我院接受治疗的84例哮喘儿童为研究对象,根据致敏原因将所有患者分为两组,其中观察组为多重致敏,共43例患者,对照组为单一致敏,共41例,比较两组患者的CD4+细胞和CD8+细胞及两者的比值、Th1细胞和Th2细胞及两者的比值、Tregs细胞和Th17细胞及两者的比值。结果观察组患者的CD4+细胞高于对照组患者,CD8+T细胞低于对照组患者,且两者比值更大 ...
曾建兴 +5 more
doaj
Expression and Significance of gp96 and Immune-related Gene CTLA-4, CD8 in Lung Cancer Tissues [PDF]
, 2010 Background and objective It has been proven that gp96 plays an important role in specific cytotoxic immune response which is involved in anti-tumor effect in the body.
Haiyan ZHENG +4 more
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