Results 41 to 50 of about 13,733 (166)

TLR-2信号途径对新生儿免疫系统在淋巴细胞增殖和调节性T细胞扩增方面的影响

open access: yesZhongguo shiyan zhenduanxue, 2006
目的探讨TLR-2(Toll like receptor-2)信号途径对新生儿免疫系统在淋巴细胞增殖和调节性T细胞(Treg)扩增方面的影响及其与成人免疫系统的差别。方法应用TLR-2的配体-肽聚糖(PPG)和有丝分裂原-植物凝血素(PHA)刺激胎儿脐带血单核淋巴细胞(CBMC)和成人外周血单核淋巴细胞(PBMC),然后采用3H胸腺嘧啶掺入法测淋巴细胞增殖情况及流式细胞技术检测活化T细胞,Treg细胞扩增情况。结果PPG和PHA刺激后,CBMC淋巴细胞总体明显增殖(P0.05)。PPG和PHA刺激后 ...
刘晶, 赵洪艳
doaj  

The preliminary study on the dyslipidemia in rats with autoimmune myocarditis [PDF]

open access: yes, 2016
目的:心肌炎是心肌间质中局限或弥漫性的急性或慢性炎症,目前关于心肌炎中血脂代谢的相关研究较少,本课题通过建立大鼠实验性自身免疫性心肌炎模型(EAM模型),初步探讨心肌炎中血脂代谢紊乱可能的分子调节机制。 方法:利用猪心肌肌球蛋白和完全弗氏佐剂充分混合后,于第0天皮下注射建立大鼠EAM模型,留取心脏标本行组织切片H&E染色、心脏体重比、RealtimePCR、Westernblot评估心肌组织炎症程度;GPO-PAP法血脂试剂盒检测血脂水平;Filipin染色检测心肌组织内胆固醇水平 ...
戴东黎
core  

NIR‐Responsive Nano‐Integrated Magnesium Phosphate Cement Promotes Bone Regeneration via Osteoblast‐Exosome‐Osteoclast Crosstalk

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT The limited osteogenic capacity of magnesium phosphate cement (MPC) has constrained its biomedical applications, underscoring the necessity to develop MPC with enhanced physical properties and bone‐forming capabilities. In this study, a multifunctional MPC system was developed by incorporating zoledronic acid‐loaded near‐infrared (NIR ...
Bin Wang   +8 more
wiley   +1 more source

肾细胞癌患者T淋巴细胞亚群动态分析

open access: yesZhongguo shiyan zhenduanxue, 2010
目的探讨肾细胞癌患者手术治疗前后外周血T淋巴细胞亚群的变化特征,为了解病情、判断预后提供免疫学依据。方法应用三色荧光素标记CD4、CD8、CD3的单克隆抗体,对外周血淋巴细胞进行标记后,应用流式细胞仪进行检测分析。结果肾细胞癌患者CD3+、CD4+T细胞明显低于正常对照组,CD8+T细胞明显高于正常对照组,CD4/CD8比值倒置;肾细胞癌患者手术后CD3+、CD4+T细胞较术前明显升高,CD4/CD8比值恢复正常。结论肾细胞癌患者T淋巴细胞百分率异常,存在细胞免疫功能紊乱现象;手术后有效去除瘤负荷 ...
叶兴龙, 宋玉国
doaj  

The Systemic Evaluation and Clinical Significance of Immunological Function for Advanced Lung Cancer Patients [PDF]

open access: yes, 2010
Background and objective The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time.
Hui ZHANG   +12 more
core  

Cu‐Enhanced Medium‐Entropy TiZrCoCrMo Alloys: Balancing Superior Antibacterial and Osteogenic Properties for Orthopedic Implants

open access: yesRare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT This study introduces novel nonequiatomic TiZrCoCrMoCux (x = 0, 5, 10; at%) medium‐entropy alloys (MEAx) tailored for orthopedic implants, synergistically combining the biocompatibility of Ti‐based alloys, the wear resistance of CoCrMo alloys, and the antibacterial/osteogenic attributes of Cu. The alloy's microstructure, mechanical properties,
Hang Yu   +9 more
wiley   +1 more source

The Effect C-X-C Motif Chemokine 10 Exert to Acute Rejection in Rat Allogenic Cardiac Retransplantation Model [PDF]

open access: yes, 2016
目的 γ干扰素诱导的蛋白10(IP-10/CXCL10)在器官初次移植排斥反应中起着重要作用,但其在再次移植中的作用仍不明确,本文主要研究趋化因子CXCL10是否能够对再次移植急性排斥反应的产生影响;由于记忆性T细胞的存在,心脏再次移植排斥反应对传统免疫抑制剂不敏感,因此,在再次移植基础上应用特异性CXCL10抗体来观察其是否能够减轻再次移植物炎症细胞浸润,延长心脏再次移植的存活时间。 方法 实验一、对照组(HTx):仅接受一次腹腔异位心脏移植;实验组(HRTx ...
许佳承
core  

Policies and reporting guidelines for small biopsy specimens of mediastinal masses [PDF]

open access: yes, 2014
目前,胸腺恶性肿瘤治疗方案大多是根据术\ud 后病理确定,然而,多数临床治疗决策需要在术前\ud 通过活检小标本的病理报告来制定。所以,术前活\ud 检小标本的正确获取和病理解读对治疗决策的制定\ud 显得非常重要[1]。这些标本包括细针活检标本,带\ud 芯穿刺活检标本和手术切取活检标本[2-7]。由于胸\ud 腺肿瘤的病理诊断对组织的获取方法和获取量都有较高\ud 的要求,加之对病理的描述也没有统一的标准,使得小\ud 标本在诊断胸腺瘤方面存在诸多问题。为此,ITMIG在\ud ...
Marchevsky, A   +7 more
core   +3 more sources

Single Cold Atmospheric Plasma Therapy May Improve the Treatment Outcome of Canine Otitis Externa With Secondary Infection

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 103-110, February 2026.
Background: Otitis externa with secondary bacterial or yeast infection is a common problem in small animal practice. Cold physical plasma (CPP) has been reported to have antimicrobial activity in vitro. Results: Ears treated additionally with CPP showed lower otic scores after 21 days compared to nontreated ears, although this difference was not ...
Ralf S. Mueller, Cosima Bouassiba
wiley   +1 more source

多发性硬化患者T细胞克隆中CD3CD56双阳性细胞的分析 附视频

open access: yesZhongguo shiyan zhenduanxue, 2000
目的多发性硬化(MS)是一种器官特异的自身免疫病,病变侵犯中枢神经系统。MS不仅有T,B细胞介导,而 且与脑淋巴瘤的发生有密切关系。方法本文用T细胞克隆技术,细胞表型分析技术和细胞毒活性分析经MBP抗原肽治疗 的MS患者外周血的T,B淋巴细胞(另文发表)。结果经MBP抗原肽诱导的T细胞克隆中有相当一部分T细胞系不仅高 表达 CD3CD56双阳性标志(NKT细胞), 50.7%±4.9%,对照为 6.0%和 3.0%,而其他神经系统疾病分别是 11.0%和 20.0%,且 ...
陈雪华   +15 more
doaj  

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