Results 171 to 180 of about 921 (215)

T-2 toxin is hydroxylated by chicken CYP3A37

Food and Chemical Toxicology, 2013
T-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed and food. It is important to know the metabolic pathway and kinetics of T-2 in food animals given that T-2 can cause serious adverse effects on human health.
Yiyang, Yuan, Xiaojie, Zhou, Jiannan, Yang, Mei, Li, Xinghui, Qiu   +4 more
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Review of neurotoxicity of T-2 toxin

Mycotoxin Research
T-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical properties, making it difficult to remove from food and feed. Hence, T-2 toxin has become an unavoidable pollutant in food for humans and animals.
Youshuang Wang, Bo Wang, Peilin Wang, Zeao Hua, Shanshan Zhang, Xuebing Wang, Xu Yang, Cong Zhang   +7 more
openaire   +2 more sources

Characterisation of hemolysis induced by T-2 toxin

Biochimica et Biophysica Acta (BBA) - General Subjects, 1985
The erythrocyte constitutes a good model system for the study of membrane-associated toxicity events caused by the trichothecene mycotoxin, T-2. This study confirms that T-2 has a direct lytic effect on erythrocytes. Lysis of guinea pig red cells requires approx. 10(10) molecules/cell and reaches plateau values after 4-6 h.
M I, Gyongyossy-Issa, V, Khanna, G G, Khachatourians   +2 more
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The effect of T-2 toxin on human platelets

Toxicology and Applied Pharmacology, 1984
Human platelets were incubated with T-2 toxin, the most toxic component of Fusarium fungi, at doses of 5 to 500 micrograms/10(9) platelets. A dose-related inhibition of platelet aggregation and release of dense bodies (these consist mainly of serotonin-containing granules) were observed. A change in membrane permeability in the absence of shape changes
R, Yarom, R, More, A, Eldor, B, Yagen
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Cardiomyopathy induced by T-2 toxin in rats

Food and Chemical Toxicology, 2020
T-2 toxin, A trichothecenes mycotoxin, is immunotoxic to animals and humans. Although it is highly cardiotoxic, the pathogenesis of cardiomyopathy caused by T-2 toxin is not entirely clear. Hence, in our research, cardiomyopathy was induced by a single injection of T-2 mycotoxin (0.23 mg/kg s.c., 1 LD50) to Wistar rats. The cardiac tissue was carefully
Vesna Jaćević, Qinghua Wu, Eugenie Nepovimova, Kamil Kuča   +3 more
openaire   +2 more sources

Metabolic effects of trichothecene T-2 toxin

Canadian Journal of Physiology and Pharmacology, 1990
Cereals and other agricultural products contaminated with trichothecene mycotoxins are unfit for consumption. Until recently, the metabolic effects of T-2 toxin (T-2) were thought to reside in its ability to inhibit protein synthesis. It is now clear that trichothecenes have multiple effects, including inhibition of DNA, RNA, and protein synthesis in ...
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T-2 toxin mycotoxicosis in the guinea-pig

Food and Cosmetics Toxicology, 1978
Summary Purified T-2 toxin dissolved in saline-dimethylsulphoxide (DMSO) 10: 1 (v/v) was administered by gastric intubation in single doses of 1·85, 2·52, 3·45 and 4·66 mg/kg body weight to male guinea-pigs. The acute oral LD 50 in the male guinea-pig was estimated to be 3·06 (2·38–3·93) mg/kg.
D B, DeNicola, A H, Rebar, W W, Carlton, B, Yagen   +3 more
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The hemolytic activity of deoxynivalenol and T‐2 toxin

Natural Toxins, 1992
AbstractThe hemolytic effects of deoxynivalenol (DON) and T‐2 toxin (T‐2) individually on rat erythrocytes were studied at different concentrations. Sodium azide was used as an enzyme inhibitor to prevent T‐2 toxin metabolism. The concentration of T‐2 was controlled by GC‐MS and no decrease of the toxin was found during the time of the experiment.
A F, Rizzo, F, Atroshi, T, Hirvi, H, Saloniemi   +3 more
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Enzymatic hydrolysis of T-2 toxin for the quantitative determination of total T-2 and HT-2 toxins in cereals

Analytical and Bioanalytical Chemistry, 2009
The selective enzymatic deacetylation of T-2 toxin to give HT-2 toxin has been investigated in aqueous crude extracts of different cereals and exploited to develop an analytical method for the determination of the sum of T-2 and HT-2 toxins. The method has been validated for the analysis of total T-2 and HT-2 toxins in maize, wheat, and oats, showing ...
Lattanzio VMT, Solfrizzo M, Visconti A
openaire   +5 more sources

Biosynthesis and preparation of T-2 Toxin, HT-2 Toxin and Neosolantol

Mycotoxin Research, 1987
Biosynthesis of trichothecenes by strains ofF. sporotriahioides KF 9 6 and KF 530 was performed on rice as a medium. Three toxins in significant amounts were produced, with yield: T-2 toxin 0.7g from 600g of drv culture, being the highest of the three metabolites, HT-2 toxin 0.06g an Neosolaniol 0.015g.
M, Kostecki, H, Jeleń, P, Gliński, J, Chełkowski   +3 more
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