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Review of the Reproductive Toxicity of T-2 Toxin
Journal of Agricultural and Food Chemistry, 2020T-2 toxin, an inevitable environmental pollutant, is the most toxic type A trichothecene mycotoxin. Reproductive disruption is a key adverse effect of T-2 toxin. Herein, this paper reviews the reproductive toxicity of T-2 toxin and its mechanisms in male and female members of different species.
Miao Song, Yanfei Li, Yanfei Li
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A review of anorexia induced by T-2 toxin
Food and Chemical Toxicology, 2023The presence of anorexia in animals is the most well-known clinical symptom of T-2 toxin poisoning. T-2 toxin is the most characteristic type A toxin in the trichothecene mycotoxins. The consumption of T-2 toxin can cause anorexic response in mice, rats, rabbits, and other animals. In this review, the basic information of T-2 toxin, appetite regulation
Ting-Yu, Huang +8 more
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Immunoperoxidase localization of T-2 toxin
Toxicology and Applied Pharmacology, 1984Antibody against T-2 toxin was used for monitoring the fate of T-2 toxin in mice given a single po dose of 11 mg/kg by the peroxidase-antiperoxidase (PAP) method. T-2 toxin was demonstrable in the esophagus from 5 min to about 24 hr postdosing. In the stomach, T-2 toxin was detected within the cytoplasm of intact and injured epithelial cells.
S C, Lee, J T, Beery, F S, Chu
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Metabolic Pathways of T-2 Toxin
Current Drug Metabolism, 2008Among the naturally-occurring trichothecenes found in food and feed, T-2 toxin is the most potent and toxic mycotoxin. After ingestion of T-2 toxin into the organism, it is processed and eliminated. Some metabolites of this trichothecene are equally toxic or slightly more toxic than T-2 itself, and therefore, the metabolic fate of T-2 toxin has been of
Vlastimil, Dohnal +3 more
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Toxicity and detoxification of T-2 toxin in poultry
Food and Chemical Toxicology, 2022This review summarizes the updated knowledge on the toxicity of T-2 on poultry, followed by potential strategies for detoxification of T-2 in poultry diet. The toxic effects of T-2 on poultry include cytotoxicity, genotoxicity, metabolism modulation, immunotoxicity, hepatotoxicity, gastrointestinal toxicity, skeletal toxicity, nephrotoxicity ...
Shao-Ji Li +8 more
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Acta Crystallographica Section C Crystal Structure Communications, 1990
C 24 H 34 O 9 cristallise dans P2 1 2 1 2 1 avec a=7,808, b=15,800, c=40,891 A, z=8; affinement jusqu'a R=0,055. La formule structurale etablie chimiquement a ete corroboree. Les deux molecules dans la maille asymetrique different seulement par leurs angles de torsion des chaines ester ...
R. Gilardi +2 more
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C 24 H 34 O 9 cristallise dans P2 1 2 1 2 1 avec a=7,808, b=15,800, c=40,891 A, z=8; affinement jusqu'a R=0,055. La formule structurale etablie chimiquement a ete corroboree. Les deux molecules dans la maille asymetrique different seulement par leurs angles de torsion des chaines ester ...
R. Gilardi +2 more
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Interaction of T-2 toxin with murine lymphocytes
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984T-2 toxin is taken up by lymphocytes in 10-15 min in a saturable manner. Uptake is dependent on temperature and partially on the availability of energy. Approx. 10(5) molecules of T-2 toxin are bound per cell, having a mean affinity constant, Ka = 1.6 X 10(7) M-1. The toxin is rapidly dissociated from the cell to leave approx.
Gyongyossy, issa M, Khachatourians, G G
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Journal of the American Veterinary Medical Association, 1973
SUMMARY Fusarium tricinctum is consistently the most toxigenic fungus isolated from moldy corn in low-temperature storage. Isolants of this fungus produce T-2 toxin, diacetoxyscirpenol, and a butenolide. The acute oral ld50 of T-2 toxin is approximately 4 mg./kg. of body weight in swine and rats and 6.5 mg./kg. of body weight in rainbow trout.
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SUMMARY Fusarium tricinctum is consistently the most toxigenic fungus isolated from moldy corn in low-temperature storage. Isolants of this fungus produce T-2 toxin, diacetoxyscirpenol, and a butenolide. The acute oral ld50 of T-2 toxin is approximately 4 mg./kg. of body weight in swine and rats and 6.5 mg./kg. of body weight in rainbow trout.
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Chromatographic enzyme immunoassay for T-2 toxin
Journal of Immunological Methods, 1990Both the active ester and maleimide moieties of the cross-linking reagent, N-[(gamma-maleimidobutyryl)oxy]succinimide (GMBS), were found to react with the primary amino groups on ribonuclease (RNase). This largely inactivated RNase towards a polymeric (but not monomeric) substrate.
B A, Warden +5 more
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