Results 181 to 190 of about 2,650,641 (236)
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Improved preparation of T-2 toxin-protein conjugates
Toxicon, 1988T-2 toxin (T-2) was converted into T-2 hemisuccinate (T-2 HS), T-2 hemiglutarate (T-2 HG) and T-2 hemiphthalate (T-2 HP), and conjugated with bovine serum albumin (BSA), ovalbumin (OVA) and keyhole limpet haemocyanin (KLH) using carbodiimide under various conditions.
K, Ohtani, O, Kawamura, Y, Ueno
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Characterisation of hemolysis induced by T-2 toxin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985The erythrocyte constitutes a good model system for the study of membrane-associated toxicity events caused by the trichothecene mycotoxin, T-2. This study confirms that T-2 has a direct lytic effect on erythrocytes. Lysis of guinea pig red cells requires approx. 10(10) molecules/cell and reaches plateau values after 4-6 h.
M I, Gyongyossy-Issa +2 more
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T-2 toxin inhibits mitochondrial function in yeast
Biochemical and Biophysical Research Communications, 1988T-2 toxin inhibits oxygen consumption of whole cells and purified mitochondria of Saccharomyces cerevisiae. Inhibition of mitochondrial respiration is not relieved by 2, 4-dinitrophenol, indicating that T-2 toxin inhibits mitochondrial function at the level of the electron transport chain. T-2 toxin inhibition of state 3 respiration (with succinate) is
H, Koshinsky +2 more
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T-2 toxin effect on cultured myocardial cells
Toxicology Letters, 1986Beat rate, contractility and viability of cultured myocardial cells perfused with solutions containing various concentrations of T-2 toxin were studied. While doses below 50 micrograms/ml had no immediate effect, those above 250 micrograms/ml decreased beat rate and amplitude.
R, Yarom +5 more
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T-2 toxin mycotoxicosis in the guinea-pig
Food and Cosmetics Toxicology, 1978Summary Purified T-2 toxin dissolved in saline-dimethylsulphoxide (DMSO) 10: 1 (v/v) was administered by gastric intubation in single doses of 1·85, 2·52, 3·45 and 4·66 mg/kg body weight to male guinea-pigs. The acute oral LD 50 in the male guinea-pig was estimated to be 3·06 (2·38–3·93) mg/kg.
D B, DeNicola +3 more
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Hepatic subcellular distribution of [3H]T-2 toxin
Toxicon, 1989The subcellular distribution of T-2 mycotoxin and its metabolites was studied in isolated rat livers perfused with [3H]T-2 toxin. After a 120-min perfusion, the distribution of radiolabel was to bile 53%, perfusate 38% and liver 7%. Livers were fractionated into mitochondria, endoplasmic reticulum (smooth and rough), plasma membrane and nuclei.
J G, Pace, M R, Watts
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Biosynthesis and preparation of T-2 Toxin, HT-2 Toxin and Neosolantol
Mycotoxin Research, 1987Biosynthesis of trichothecenes by strains ofF. sporotriahioides KF 9 6 and KF 530 was performed on rice as a medium. Three toxins in significant amounts were produced, with yield: T-2 toxin 0.7g from 600g of drv culture, being the highest of the three metabolites, HT-2 toxin 0.06g an Neosolaniol 0.015g.
M, Kostecki +3 more
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A monoclonal antibody to T-2 toxin
Letters in Applied Microbiology, 1987A specific, high affinity monoclonal antibody to T-2 toxin of Fusarium has been produced. The monoclonal antibody was conjugated to horse-radish peroxidase and employed to develop a direct competitive enzyme-linked immunosorbent assay (ELISA) for the toxin. The sensitivity of the ELISA was 10 ng/ml with a working range up to 500 ng/ml.
I. A. GOODBRAND +2 more
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