T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies [PDF]
Molecules, 2021 Among trichothecenes, T-2 toxin is the most toxic fungal secondary metabolite produced by different Fusarium species. Moreover, T-2 is the most common cause of poisoning that results from the consumption of contaminated cereal-based food and feed ...
Edyta Janik +5 more
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Tibial Damage Caused by T-2 Toxin in Goslings: Bone Dysplasia, Poor Bone Quality, Hindered Chondrocyte Differentiation, and Imbalanced Bone Metabolism [PDF]
AnimalsT-2 toxin, the most toxic type A trichothecene, is widely present in grain and animal feed, causing growth retardation and tissue damage in poultry. Geese are more sensitive to T-2 toxin than chickens and ducks.
Wang Gu +4 more
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Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures [PDF]
Scientific ReportsDespite being one of the most common contaminants of poultry feed, the molecular effects of T-2 toxin on the liver of the exposed animals are still not fully elucidated.
Júlia Vörösházi +8 more
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T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation [PDF]
Advanced ScienceT‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Tushuai Li +6 more
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Screening, Identification and Action Mechanism of T-2 Toxin-Degrading Strains [PDF]
Shipin Kexue, 2023 The purpose of this study was to obtain microbial strains capable of high-efficiency degradation of T-2 toxin and to investigate their mechanism of action.
MA Yan, SUN Changpo, WANG Jun, DU Wen, LIU Hujun, ZHOU Wenhua, ZHAO Yifan
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T-2 mycotoxin Induces male germ cell apoptosis by ROS-mediated JNK/p38 MAPK pathway
Ecotoxicology and Environmental Safety, 2023 T-2 mycotoxin, a type A trichothecene toxin that, specifically, causes male and female reproductive toxicity. We evaluated T-2 toxin toxicity in testes from neonatal testes after in vitro tissue cultured.
Won-Young Lee, Hyun-Jung Park
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p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder
Ecotoxicology and Environmental Safety, 2023 T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human and animal health. Exposure to T-2 toxin can cause testosterone synthesis disorder in male animals, but the molecular mechanism is still not completely clear.
Xu Yang +9 more
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Ecotoxicology and Environmental Safety, 2022 T-2 toxin belongs to the trichothecenes group A compound, mainly produced by Fusarium fungi. It has been shown that T-2 toxin could cross the placental barrier and breast milk, thus endangering the health of offspring.
Ruifen Kang +4 more
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New process for T-2 toxin production [PDF]
Applied and Environmental Microbiology, 1982 Strains of Fusarium produced high levels of T-2 toxin when cultured on certain media absorbed into vermiculite. Modified Gregory medium was nutritionally complex (2% soya meal, 0.5% corn steep liquor, 10% glucose) and, when inoculated with the appropriate fungal strain, yielded maximum T-2 toxin within 24 days of incubation at 19 degrees C.
D, Cullen, E B, Smalley, R W, Caldwell
openaire +2 more sources
Study on the apoptosis mechanism induced by T-2 toxin. [PDF]
PLoS ONE, 2013 T-2 toxin is known to induce apoptosis in mammalian cells. The mechanism of apoptosis induced by T-2 toxin has been proposed to be linked with oxidative stress and mitochondrial pathway.
Zhenhong Zhuang +3 more
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