Results 21 to 30 of about 383,521 (254)
Production of antibody against T-2 toxin [PDF]
Applied and Environmental Microbiology, 1979 Antibody against T-2 toxin was obtained after immunization of rabbits with bovine serum albumin-T-2 hemisuccinate conjugate. The antibody had greatest binding efficiency for T-2 toxin, less efficiency for HT-2, and least for T-2 triol. Cross-reaction of antibody with neosolaniol, T-2 tetraol, and 8-acetyl-neosolaniol was very weak.
F S, Chu +3 more
openaire +2 more sources
In Vitro Metabolism of T-2 Toxin [PDF]
Applied Microbiology, 1974 Incubation of T-2 toxin with the 9,000 × g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver.
R A, Ellison, F N, Kotsonis
openaire +2 more sources
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Ecotoxicology and Environmental Safety, 2023 The most prevalent contaminated mycotoxin in feed and grain is T-2 toxin. The T-2 toxin's primary action target is the gut because it is the main organ of absorption.
Fengjuan Chen +6 more
doaj +1 more source
T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes
Toxins, 2020 T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis.
Huadong Yin +5 more
doaj +1 more source
Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins
Toxins, 2019 In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu +4 more
doaj +1 more source
T-2 toxin causes dysfunction of Sertoli cells by inducing oxidative stress
Ecotoxicology and Environmental Safety, 2021 T-2 toxin is an inevitable mycotoxin in food products and feeds. It is a proven toxicant impairing the male reproductive system. However, previous studies have concentrated on the toxic effect of T-2 toxin on Leydig cells, with little attention on the ...
Xu Yang +6 more
doaj +1 more source
Efficacy of T-2 toxin detoxifying agent in broiler chickens [PDF]
Acta Veterinaria, 2012 This investigation was conducted in order to investigate the efficacy of the detoxifying agent Mycofix® Plus (MP) in the prevention and/or alleviation in vivo adverse effects of T-2 toxin in broilers.
Nešić V. +6 more
doaj +1 more source
Mitochondrial Damage Induced by T-2 Mycotoxin on Human Skin—Fibroblast Hs68 Cell Line
Molecules, 2023 T-2 toxin is produced by different Fusarium species and belongs to the group of type A trichothecene mycotoxins. T-2 toxin contaminates various grains, such as wheat, barley, maize, or rice, thus posing a risk to human and animal health.
Edyta Janik-Karpinska +5 more
doaj +1 more source
Journal of Toxicologic Pathology, 2006 T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. This paper reviews the reported data about the development and/or mechanisms of T-2 toxin-induced apoptosis in the hematopoietic, lymphoid and gastrointestinal tissues, dorsal skin and fetal tissues of mice and rats.
Kunio Doi +2 more
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Structure-function analysis of porcine cytochrome P450 3A29 in the hydroxylation of T-2 toxin as revealed by docking and mutagenesis studies. [PDF]
PLoS ONE, 2014 T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin.
Guyue Cheng +8 more
doaj +1 more source