Results 21 to 30 of about 399,149 (348)

Effects of T-2 toxin on growth performance, feather quality, tibia development and blood parameters in Yangzhou goslings. [PDF]

Poult Sci, 2023
: T-2 toxin is a dangerous natural pollutant and widely exists in animal feed, often causing toxic damage to poultry, such as slow growth and development, immunosuppression, and death. Although geese are considered the most sensitive poultry to T-2 toxin,
Gu W, Bao Q, Weng K, Liu J, Luo S, Chen J, Li Z, Cao Z, Zhang Y, Zhang Y, Chen G, Xu Q.   +11 more
europepmc   +2 more sources

Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis. [PDF]

Front Genet, 2022
Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, the mechanisms underlying damaged articular cartilage induced by T-2 toxin have not been elucidated.
Shi L, Liu Q, Yang H, Wang Q, Wang J, Fan Y.   +5 more
europepmc   +2 more sources

T-2 Toxin-The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies. [PDF]

Molecules, 2021
Among trichothecenes, T-2 toxin is the most toxic fungal secondary metabolite produced by different Fusarium species. Moreover, T-2 is the most common cause of poisoning that results from the consumption of contaminated cereal-based food and feed ...
Janik E, Niemcewicz M, Podogrocki M, Ceremuga M, Stela M, Bijak M.   +5 more
europepmc   +2 more sources

Tibial Damage Caused by T-2 Toxin in Goslings: Bone Dysplasia, Poor Bone Quality, Hindered Chondrocyte Differentiation, and Imbalanced Bone Metabolism. [PDF]

Animals (Basel)
T-2 toxin, the most toxic type A trichothecene, is widely present in grain and animal feed, causing growth retardation and tissue damage in poultry. Geese are more sensitive to T-2 toxin than chickens and ducks.
Gu W, Hou L, Bao Q, Xu Q, Chen G.
europepmc   +2 more sources

Study on the apoptosis mechanism induced by T-2 toxin. [PDF]

PLoS ONE, 2013
T-2 toxin is known to induce apoptosis in mammalian cells. The mechanism of apoptosis induced by T-2 toxin has been proposed to be linked with oxidative stress and mitochondrial pathway.
Zhenhong Zhuang, Daibin Yang, Yaling Huang, Shihua Wang   +3 more
doaj   +1 more source

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review. [PDF]

Anim Nutr
T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed. It can cause gastrointestinal toxicity, hepatotoxicity, immunotoxicity, reproductive toxicity, neurotoxicity, and nephrotoxicity in humans and animals.
Wang P, Sun LH, Wang X, Wu Q, Liu A.
europepmc   +2 more sources

Investigation of the effects of T-2 toxin in chicken-derived three-dimensional hepatic cell cultures. [PDF]

Sci Rep
Despite being one of the most common contaminants of poultry feed, the molecular effects of T-2 toxin on the liver of the exposed animals are still not fully elucidated.
Vörösházi J, Mackei M, Sebők C, Tráj P, Márton RA, Horváth DG, Huber K, Neogrády Z, Mátis G.   +8 more
europepmc   +2 more sources

T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes

Toxins, 2020
T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis.
Huadong Yin, Shunshun Han, Yuqi Chen, Yan Wang, Diyan Li, Qing Zhu   +5 more
doaj   +1 more source

Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins

Toxins, 2019
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Guo   +4 more
doaj   +1 more source

Analysis of Mechanisms of T-2 Toxin Toxicity Using Yeast DNA Microarrays [PDF]

, 2008
T-2 toxin is a mycotoxin that belongs to a group of type A tricothecenes found in agricultural products. The cytotoxicity of T-2 toxin was characterized by analysis of the yeast transcriptome upon challenge with T-2 toxin.
Ahmadi, Boulton, Butty, Butty, Celenza, Chang, Elion, Emiko Kitagawa, Fu, Fujimura, Hardie, Henchoz, Hitoshi Iwahashi, Hoffman, Hung, Iwahashi, Iwahashi, Iwahashi, Jiang, Kahn, Kahn, Kitagawa, Kitagawa, Mendenhall, Momose, Murata, Parveen, Peter, Peter, Santt, Sehata, Sehata, Sehata, Stephanie, Sugita-Konishi, Symington, Yumiko Iwahashi   +36 more
core   +3 more sources