Results 51 to 60 of about 2,650,641 (236)

T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2

International Journal of Molecular Sciences, 2021
T-2 toxin is mainly produced by Fusarium species, which is an extremely toxic mycotoxin to humans and animals. It is well known that T-2 toxin induces oxidative stress, but the molecular mechanism is still unknown.
Xiaoxuan Chen, Peiqiang Mu, Lang Zhu, Xiaoxiao Mao, Shuang Chen, H. Zhong, Yiqun Deng   +6 more
semanticscholar   +1 more source

The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis. [PDF]

PLoS ONE, 2014
T-2 toxin, a mycotoxin produced by Fusarium species, has been shown to cause diverse toxic effects in animals and is also a possible pathogenic factor of Kashin-Beck disease (KBD). The role of mitochondria in KBD is recognized in our recent research. The
Jiangtao Liu, Linlin Wang, Xiong Guo, Qingjiang Pang, Shixun Wu, Cuiyan Wu, Peng Xu, Yidong Bai   +7 more
doaj   +1 more source

T-2 Toxin: Incidence and Toxicity in Poultry [PDF]

Archives of Industrial Hygiene and Toxicology, 2008
T-2 Toxin: Incidence and Toxicity in PoultryT-2 toxin is the most toxic type A trichothecene mycotoxin. It is the secondary metabolite of the Fusarium fungi, and is common in grain and animal feed. Toxic effects have been shown both in experimental animals and in livestock. It has been implicated in several outbreaks of human mycotoxicoses.
Sokolović, Marijana, Garaj-Vrhovac, Verica, Šimpraga, Borka   +2 more
openaire   +4 more sources

T-2 Toxin-Induced Oxidative Stress Leads to Imbalance of Mitochondrial Fission and Fusion to Activate Cellular Apoptosis in the Human Liver 7702 Cell Line

Toxins, 2020
T-2 toxin, as a highly toxic mycotoxin to humans and animals, induces oxidative stress and apoptosis in various cells and tissues. Apoptosis and mitochondrial fusion/fission are two tightly interconnected processes that are crucial for maintaining ...
Jun-Hua Yang, Wenbo Guo, Jianhua Wang, Xianli Yang, Zhiqi Zhang, Zhihui Zhao   +5 more
semanticscholar   +1 more source

T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1

Ecotoxicology and Environmental Safety, 2023
The T-2 toxin and deoxynivalenol (DON), as the most concerned members of trichothecenes, induce cellular stress responses and various toxic effects. Stress granules (SGs) are rapidly formed in response to stress and play an important role in the cellular
Tianqing Jiang, Xueying Qi, Ruqin Lin, Jun Jiang, Jikai Wen, Yiqun Deng   +5 more
doaj   +1 more source

Radioimmunoassay of T-2 Toxin in Biological Fluids

Journal of AOAC INTERNATIONAL, 1981
Abstract A simple radioimmunoassay (RIA) for detection of T-2 toxin in biological fluids was developed. The method, which involves a Sep-Pak C18 reverse phase column cleanup step before RIA, can detect 0.5 ppb T-2 toxin in serum and 2.5 ppb T-2 toxin in urine and milk. Recoveries for toxin added to serum and urine or milk samples were 87-
S, Lee, F S, Chu
openaire   +2 more sources

The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig

Veterinary Research, 2012
T-2 toxin is known to be one of the most toxic trichothecene mycotoxins. Exposure to T-2 toxin induces many hematologic and immunotoxic disorders and is involved in immuno-modulation of the innate immune response.
Seeboth Julie, Solinhac Romain, Oswald Isabelle P, Guzylack-Piriou Laurence   +3 more
doaj   +1 more source

Nrf2: A Main Responsive Element of the Toxicity Effect Caused by Trichothecene (T-2) Mycotoxin

Toxics, 2023
T-2 toxin, the most toxic type A trichothecene mycotoxin, is produced by Fusarium, and is widely found in contaminated feed and stored grains. T-2 toxin is physicochemically stable and is challenging to eradicate from contaminated feed and cereal ...
Youshuang Wang, Yu Liu, Tingyu Huang, Yunhe Chen, Wenxi Song, Fengjuan Chen, Yibao Jiang, Cong Zhang, Xu Yang   +8 more
doaj   +1 more source

Gene expression in farm poultry under the influence of T-2 toxin and the use of biological preparations

Acta Biomedica Scientifica, 2022
Background. Feed-borne T-2 toxin may inhibit innate immune system function in birds.The aim. To evaluate the effect of T-2 toxin, artificially introduced with feed, on the expression level of a number of immunity-related genes in the tissues of the ...
E. A. Yildirim, A. A. Grozina, L. A. Ilina, V. A. Filippova, G. Y. Laptev, E. S. Ponomareva, A. V. Dubrowin, K. A. Kalitkina, V. V. Molotkov, D. A. Akhmatchin, D. G. Tiurina   +10 more
doaj   +1 more source

Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway

Toxins, 2020
T-2 toxin, a trichothecene mycotoxin produced by Fusarium, is widely distributed in crops and animal feed and frequently induces intestinal damage.
Chenxi Luo, Chenglong Huang, Lijuan Zhu, L. Kong, Zhihang Yuan, L. Wen, Rongfang Li, Jing Wu, J. Yi   +8 more
semanticscholar   +1 more source