Results 161 to 170 of about 14,413,699 (306)

Comprehensive mapping of human CD4⁺ T cell epitopes for Nipah and measles as prototype Paramyxoviruses. [PDF]

Cell Rep Med
Tarke A, Macias M, Morales CF, Michaelis T, Siddiqui L, Yu ED, Trevizani R, Zuniga A, Zmasek C, Phillips E, Mallal S, Lin B, Estevez JO, Erlich JR, Johnson NV, McLellan JS, Frazier A, da Silva Antunes R, Tan GS, Grifoni A, Sette A.   +20 more
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Clinical MAPPs: a personalized healthcare-driven assay for the direct identification of potential T cell epitopes in patients. [PDF]

Front Immunol
Hartman K, Steiner G, Looney CM, Siegel M, Bray-French K, Brix K, Springer S, Hickling TP, Janssen N, Ducret A, Marban-Doran C.   +10 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Prediction of potential NS3-based T cell epitopes of hepatitis C virus by in-silico and in-vitro approach. [PDF]

Sci Rep
Dutta S, Dhar A, Pande M, Ghose A, Majumdar M, Bakshi S, Das R, Nath S, Ghosh A, Sadhukhan PC.   +9 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

TEpiNom: A computational framework integrating population data to prioritize Plasmodium falciparum T cell epitopes. [PDF]

Vaccine
Laurenson AJ, Pierce BG, Takala-Harrison S, Laurens MB.   +3 more
europepmc   +1 more source

Positional Biases of the Experimentally Characterized T-cell Epitopes

, 2018
Binding to Major Histocompatibility Complex (MHC) class I and class II molecules is the most restrictive step in T-cell epitope presentation. In humans these molecules are named Human Leukocyte Antigen (HLA) class I and II. However, only a minor part of
Jelović, Ana, Mitić, Nenad, Mirjana, Pavlović, Jandrlić, Davorka   +3 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source