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Developing T Cell Epitope-Based Vaccines Against Infection: Challenging but Worthwhile [PDF]
VaccinesT cell epitope-based vaccines are designed to elicit long-lived pathogen-specific memory T cells that can quickly activate protective effector functions in response to subsequent infections.
Xian Tang, Wei Zhang, Zheng Zhang
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T-Cell Epitope-Based Vaccines: A Promising Strategy for Prevention of Infectious Diseases [PDF]
VaccinesWith the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines.
Xin Song +4 more
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Journal of Pharmacological Sciences, 2007 The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular ...
Hiromichi Tsurui, Takuya Takahashi
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Synergistic immune protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice [PDF]
Frontiers in ImmunologyObjectiveTo evaluate the synergistic immunological protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice.MethodsRed blood cell-derived exosomes were loaded with 27 CD8+ T-cell epitope ...
Anran Shen +12 more
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Advances in T-cell epitope engineering [PDF]
Frontiers in Immunology, 2013 T-cells recognize small peptide fragments (p) cradled in multiple major histocompatibility complex (MHC) molecules, termed human leukocyte antigens (HLA) in humans. These membrane-integral pMHC molecules are present on surface of all nucleated cells and allow T-cells to detect aberrant intracellular activity, be this infection with microorganisms or ...
Johanne ePentier +4 more
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T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains [PDF]
Frontiers in MicrobiologyPorcine reproductive and respiratory syndrome virus (PRRSV) is one of the most ubiquitous RNA viruses affecting pigs and pig farms globally. While vaccines are available, they are not entirely effective, and the introduction of modified live virus ...
J. Mark Hammer +7 more
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PLoS Computational Biology, 2023 Human respiratory syncytial virus (RSV) is a major cause of lower respiratory infection. Despite more than 60 years of research, there is no licensed vaccine. While B cell response is a major focus for vaccine design, the T cell epitope profile of RSV is
Jiani Chen +6 more
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High epitope expression levels increase competition between T cells. [PDF]
PLoS Computational Biology, 2006 Both theoretical predictions and experimental findings suggest that T cell populations can compete with each other. There is some debate on whether T cells compete for aspecific stimuli, such as access to the surface on antigen-presenting cells (APCs) or
Almut Scherer +2 more
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Frontiers in Immunology, 2022 We identified SARS-CoV-2 specific antigen epitopes by HLA-A2 binding affinity analysis and characterized their ability to activate T cells. As the pandemic continues, variations in SARS-CoV-2 virus strains have been found in many countries. In this study,
Congling Qiu +32 more
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Identification and Phylogeny of the First T Cell Epitope Identified from a Human Gut Bacteroides Species. [PDF]
PLoS ONE, 2015 Host T cell reactivity toward gut bacterial epitopes has been recognized as part of disease pathogenesis. However, the specificity of T cells that recognize this vast number of epitopes has not yet been well described.
Maria Elisa Perez-Muñoz +4 more
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