T-cell epitope - Open Access .click

Results 11 to 20 of about 212,422 (259)

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

Frontiers in Immunology, 2022
Background and aimsThere is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells.
Andreas Walker +28 more
doaj +1 more source

Exploring rotavirus proteome to identify potential B- and T-cell epitope using computational immunoinformatics

Heliyon, 2020
Rotavirus is the most common cause of acute gastroenteritis in infants and children worldwide. The functional correlation of B- and T-cells to long-lasting immunity against rotavirus infection in the literature is limited.
Yengkhom Damayanti Devi +12 more
doaj +1 more source

A SARS-CoV-2 NSP7 homolog of a Treg epitope suppresses CD4+ and CD8+ T cell memory responses

Frontiers in Immunology, 2023
Pathogens escape host defenses by T-cell epitope mutation or deletion (immune escape) and by simulating the appearance of human T cell epitopes (immune camouflage).
S. M. Shahjahan Miah +7 more
doaj +1 more source

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

iScience, 2021
Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of ...
Thushan I. de Silva +1012 more
doaj +1 more source

Quantifying the Persistence of Vaccine-Related T Cell Epitopes in Circulating Swine Influenza A Strains from 2013–2017

Vaccines, 2021
When swine flu vaccines and circulating influenza A virus (IAV) strains are poorly matched, vaccine-induced antibodies may not protect from infection. Highly conserved T cell epitopes may, however, have a disease-mitigating effect.
Swan Tan +6 more
doaj +1 more source

Identification of B and T Cell Epitopes to Design an Epitope-Based Peptide Vaccine against the Cell Surface Binding Protein of Monkeypox Virus: An Immunoinformatics Study

Journal of Immunology Research, 2023
Background. Although the monkeypox virus-associated illness was previously confined to Africa, recently, it has started to spread across the globe and become a significant threat to human lives. Hence, this study was designed to identify the B and T cell
Lincon Mazumder +5 more
doaj +1 more source

Landscape and selection of vaccine epitopes in SARS-CoV-2

Genome Medicine, 2021
Background Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity
Christof C. Smith +27 more
doaj +1 more source

Ad5-nCoV Vaccination Could Induce HLA-E Restricted CD8⁺ T Cell Responses Specific for Epitopes on Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Viruses, 2023
We evaluated cellular immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in an immunized population based on HLA-E-restricted CD8+ T cell epitope identification.
Yuling Wang +9 more
doaj +1 more source

A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach

Frontiers in Immunology, 2021
Emerging infectious diseases (EIDs) caused by viruses are increasing in frequency, causing a high disease burden and mortality world-wide. The COVID-19 pandemic caused by the novel SARS-like coronavirus (SARS-CoV-2) underscores the need to innovate and ...
Patricio Oyarzun +8 more
doaj +1 more source

BepiTBR: T-B reciprocity enhances B cell epitope prediction

iScience, 2022
Summary: The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby CD4+ T cell epitopes have ...
James Zhu +5 more
doaj +1 more source

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