Results 161 to 170 of about 16,833,685 (312)

Bridging model performance and clinical utility in T cell receptor-epitope binding prediction. [PDF]

Clin Transl Med
Wang Y, Lu Y, Suo S.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

T-cell receptor alpha to beta chains binding prediction. [PDF]

Brief Bioinform
Siminovsky D, Louzoun Y.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

T Cell Receptors and Immunoregulation [PDF]

Journal of the Royal Society of Medicine, 1985
openaire   +2 more sources

Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females. [PDF]

Elife
Vantomme H, Quiniou V, Adda L, Jouannet C, Mhanna V, Albalaa C, Barennes P, Coatnoan N, Diderot V, Dubois J, Fourcade G, Le Gouge K, Nguekap Tchoumba OF, Pezous M, Stys P, Six A, Mariotti-Ferrandiz E, Klatzmann D.   +17 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Role of the T Cell Receptor Sequence in Shaping T Cell Functional Fate. [PDF]

Immunol Rev
Mantena S, Raychaudhuri S.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Clonal overlap and convergent clustering of T cell receptor signatures in Crohn's disease in monozygotic twins. [PDF]

Inflamm Bowel Dis
Brand EC, Vandoren R, Lutter L, Van Deuren VML, Servaas NH, Pandit A, Meysman P, Oldenburg B, van Wijk F, Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis .   +9 more
europepmc   +1 more source