Results 371 to 380 of about 4,863,715 (431)
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T cells with receptors for IgD
Nature, 1985The role of IgD in the immune response has been elusive, although its predominance on the cell surface suggests a receptor function. We have shown previously that euthymic but not athymic BALB/c mice, injected with IgD before antigen, exhibit enhanced antibody responses which can be transferred by T cells. Isotype-specific T cells have been reported to
B Xue +5 more
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The cell membrane and receptors
Anaesthesia & Intensive Care Medicine, 2007Abstract The plasma membrane forms the interface between the cell and its environment. It is composed essentially of a phospholipid matrix and many different types of protein molecules which may be embedded within the matrix (integral proteins) or more loosely associated with the cytoplasmic ‘face’ of the membrane (peripheral proteins).
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Journal of Pharmaceutical and Biomedical Analysis, 1989
There are four general assay methods used to quantify a drug/biologic in a preparation, including: (1) in vivo bioassays; (2) in vitro bioassays; (3) immunoassays; and (4) receptor assays. The cell receptor assay is used to evaluate the first step in the molecular action of the drug biologic, its interaction with a specific cellular receptor ...
D. Gurari-Rotman +3 more
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There are four general assay methods used to quantify a drug/biologic in a preparation, including: (1) in vivo bioassays; (2) in vitro bioassays; (3) immunoassays; and (4) receptor assays. The cell receptor assay is used to evaluate the first step in the molecular action of the drug biologic, its interaction with a specific cellular receptor ...
D. Gurari-Rotman +3 more
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Dermatologic Clinics, 1990
We have reviewed the knowledge of the human TCR and its implications in dermatology. The TCR has been shown to be the molecule responsible for specific cellular immunity in the same way that immunoglobulins confer humoral immunity. Much has been learned about the complex genomic organization of the TCR chains and how the great diversity of TCR proteins
K. Degitz, S. W. Caughman
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We have reviewed the knowledge of the human TCR and its implications in dermatology. The TCR has been shown to be the molecule responsible for specific cellular immunity in the same way that immunoglobulins confer humoral immunity. Much has been learned about the complex genomic organization of the TCR chains and how the great diversity of TCR proteins
K. Degitz, S. W. Caughman
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1989
Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
Yongwon Choi +7 more
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Mammmals have evolved a number of different ways of recognising the arrival in their bodies of a foreign invader. At least 3 of these appear to be antigen specific, by virtue of the fact that the foreign invaders are recognised by receptors which vary in sequence from one cell to another.
Yongwon Choi +7 more
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2015
On B cells, specificity is mediated by surface immunoglobulin. On T cells, specificity is mediated by the T-cell receptor (TCR) for antigen. The first indications that T cells recognized antigen through a TCR were derived from functional assays using specific target-cell interactions.
Chris Mody, Howard Ceri
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On B cells, specificity is mediated by surface immunoglobulin. On T cells, specificity is mediated by the T-cell receptor (TCR) for antigen. The first indications that T cells recognized antigen through a TCR were derived from functional assays using specific target-cell interactions.
Chris Mody, Howard Ceri
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Unplugging the T cell receptor [PDF]
Nature Immunology, 2003 Certain infectious diseases, autoimmune disorders and cancers are associated with T cell receptor ζ chain down-regulation. Interferon-γ production by T helper type 1 cells seems to be pivotal in this process.
POLI , GUIDO, BORDIGNON , CLAUDIO
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2008
The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
John G. Monroe, Randall J. Brezski
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The subunit structure of the B-cell antigen receptor (BCR) and its associated compartmentalization of function confer enormous flexibility for generating signals and directing these toward specific and divergent cell fate decisions. Like all the multichain immune recognition receptors discussed in this volume, assembly of these multi-unit complexes ...
John G. Monroe, Randall J. Brezski
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New England Journal of Medicine, 1977
Intercellular transfer of information is frequently accomplished through receptors that recognize specific chemical signals such as hormones or neurotransmitters and respond to their presence by in...
Steven Jacobs, Pedro Cuatrecasas
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Intercellular transfer of information is frequently accomplished through receptors that recognize specific chemical signals such as hormones or neurotransmitters and respond to their presence by in...
Steven Jacobs, Pedro Cuatrecasas
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Cytotherapy, 2003
Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
Alastair David Griffiths Lawson +2 more
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Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain) to the transmembrane and intracellular portion of a signaling molecule (endodomain). The ectodomain is most often derived from Ab variable chains, but may also be generated from T-cell receptor variable chains, as well as from other molecules. Various alternative
Alastair David Griffiths Lawson +2 more
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