Results 41 to 50 of about 2,073,683 (216)

Rac activation by the T-cell receptor inhibits T cell migration.

PLoS ONE, 2010
BackgroundT cell migration is essential for immune responses and inflammation. Activation of the T-cell receptor (TCR) triggers a migration stop signal to facilitate interaction with antigen-presenting cells and cell retention at inflammatory sites, but ...
Eva Cernuda-Morollón, Jaime Millán, Mark Shipman, Federica M Marelli-Berg, Anne J Ridley   +4 more
doaj   +1 more source

Generalizable design parameters for soluble T cell receptor-based T cell engagers

Journal for ImmunoTherapy of Cancer, 2022
While most biological and cellular immunotherapies recognize extracellular targets, T cell receptor (TCR) therapeutics are unique in their ability to recognize the much larger pool of intracellular antigens found on virus-infected or cancerous cells ...
Flora Huang, Arlene Sereno, Karen J Froning, Stephen J Demarest   +3 more
doaj   +1 more source

Studies on the role of Coronin 1 and the actin cytoskeleton in T cell signaling and survival [PDF]

, 2009
Calcium ions (Ca2+) function as universal second messengers in most if not all eukaryotic cells, including the cells of the immunesystem. Ca2+ signals are required for the proper activation of lymphocytes, such as T-lymphocytes, their proliferation ...
Müller, Philipp
core   +1 more source

In-depth analysis of the safety of CAR-T cell therapy for solid tumors

Frontiers in Immunology
In recent years, the rapid progress in oncology, immunology, and molecular biology has dramatically advanced cancer immunotherapy, particularly CAR-T cell therapy.
Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiexiong Wu, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Ting Su, Ting Su, Ting Su, Ting Su, Ting Su, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Size Chen, Size Chen, Size Chen, Size Chen, Size Chen   +33 more
doaj   +1 more source

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol, Male, David K, Cerutti, Camilla, Michael, G.J., Dongsheng Wu, van der Pol, SM, Sharrack, B, Romero, I.A., Baker, D., Michael, Gregory J, Simpson, Julie E., Cerutti, C., Simpson, J.E., Lopez-Ramirez, Miguel A., David Baker, Romero, IA, Wu, D.S., de Vries, H.E., Baker, David, King-Robson, J., Basil Sharrack, Simpson, Julie E, Michael, GJ, Wu, Dongsheng, van der Pol, Susanne M A, Hirst, Mark C, Julie E Simpson, Ignacio A Romero, Pryce, Gareth, Baker, D, Gregory J Michael, de Vries, Helga E, Romero, Ignacio A., Hirst, MC, King-Robson, Josh, de Vries, HE, Lopez-Ramirez, Alejandro, Mark C Hirst, David K Male, Male, DK, de Vries, Helga E., Gareth Pryce, Josh King-Robson, Camilla Cerutti, van der Pol, SMA, Romero, Ignacio A, van der Pol, S.M.A., Lopez-Ramirez, Miguel A, Male, D.K., Male, David K., Sharrack, B., King-Robson, J, van der Pol, Susanne M. A., Wu, D, Simpson, JE, Lopez-Ramirez, MA, Miguel A Lopez-Ramirez, Hirst, M.C., van der Pol, Susanne Ma, Cerutti, C, Helga E de Vries, Pryce, G, Pryce, G., Hirst, Mark C., Sharrack, Basil, Michael, Gregory J., Lopez-Ramirez, M.A.   +66 more
core   +1 more source

Responses of T cells to ligands for the T-cell receptor

Seminars in Immunology, 1996
We have learned a great deal about the recognition of MHC class II:peptide complexes by concentrating on the responses of a single cloned T-cell line, called D10. From these results, we argue for a single orientation of all CD4 T-cell receptors to their MHC ligands, based on the uneven top surface of MHC molecules, the repeated isolation of cells with ...
C A, Janeway, K, Bottomly
openaire   +2 more sources

The role of coronin 1 during cell mediated immune responses [PDF]

, 2013
Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
core   +1 more source

Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia

Haematologica, 2013
Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translocations that are genetic hallmarks in several subsets of human T-cell acute lymphoblastic leukemias.
Nicole S.D. Larmonie, Willem A. Dik, Jules P.P. Meijerink, Irene Homminga, Jacques J.M. van Dongen, Anton W. Langerak   +5 more
doaj   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

Haematologica, 2018
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation.
Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie O. Morin, Gérard Michel, Norbert Vey, Jacques A. Nunès, Bernard Malissen, Romain Roncagalli, Bertrand Nadel, Dominique Payet-Bornet   +12 more
doaj   +1 more source