Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]
, 2018 Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B. +5 more
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Force generation upon T cell receptor engagement. [PDF]
PLoS ONE, 2011 T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson +4 more
doaj +1 more source
Regulation of T Cell Apoptosis via T Cell Receptors and Steroid Receptors [PDF]
STEM CELLS, 1996 Less than 5% of immature CD4/CD8 double-positive (DP) thymocytes are positively selected to survive and differentiate into single-positive CD4 and CD8 T cells, while self-reactive DP thymocytes undergo apoptosis (negative selection). Both positive and negative selection events are active processes that involve signaling through the T cell receptors ...
M, Iwata, Y, Ohoka, T, Kuwata, A, Asada
openaire +2 more sources
A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]
, 1989 Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette +30 more
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The LCMV gp33-specific memory T cell repertoire narrows with age
Immunity & Ageing, 2012 Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam +4 more
doaj +1 more source
Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation [PDF]
, 2008 Hematopoietic stem cell transplantation (HSCT) requires conditioning treatments such as irradiation, which leads to a severely delayed recovery of T cell immunity and constitutes a major complication of this therapy.
Kenins, L. +4 more
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MAVS Is essential for primary CD4 + T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection [PDF]
, 2017 The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development.
Barrett, Alan D +11 more
core +3 more sources
Drug functional remapping: a new promise for tumor immunotherapy
Frontiers in OncologyThe research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong +27 more
doaj +1 more source
Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment. [PDF]
, 2008 Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site.
B H Belohradsky +7 more
core +1 more source
T cell receptor signaling and cell immunotherapy
National Science OpenAs the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells.
Zhang Linsong +3 more
doaj +1 more source