Results 131 to 140 of about 724,385 (326)
Advanced Healthcare Materials, EarlyView.The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang +13 more
wiley +1 more source
Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects
Advanced Healthcare Materials, EarlyView.Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt +7 more
wiley +1 more source
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
Molecular CancerCytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs.
Shengkun Peng +7 more
doaj +1 more source
Advanced Materials, EarlyView.We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam +5 more
wiley +1 more source
Autoimmune destruction of pericytes as the cause of diabetic retinopathy
Clinical Ophthalmology, 2008 Duncan D AdamsFaculty of Medicine, University of Otago, Dunedin, New ZealandAbstract: In diabetic retinopathy, collapse of the retinal vasculature is associated with loss of the pericytes.
Duncan D Adams
doaj
In vitro induction of tumor antigen-specific cytotoxic T lymphocytes (CTL) [PDF]
, 2000 Specific immune responses are normally stimulated when an individual is exposed to a foreign antigen [1-4].The form of immunity that is induced by this process of immunization is called active immunity because the immunized ...Thesis (Ph. D.
Kim Changhyun, 金 昌鉉
core
Advanced Materials, EarlyView.A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim +9 more
wiley +1 more source
Advanced Materials Technologies, EarlyView.A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi +5 more
wiley +1 more source
Intravital Imaging of Cytotoxic T Lymphocytes
, 2014 Intravital imaging approaches are proving to be essential to address new questions to better understand how the immune system operates. These approaches are especially valuable to characterize the complex organization of immune responses in vivo. Here, we examine how to take advantage of the cornea as a natural body window to apply noninvasive imaging ...
Gaetano, Faleo +2 more
openaire +3 more sources
Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis
Science immunology, 2018 Veena S Patil +11 more
semanticscholar +1 more source