Results 71 to 80 of about 164,918 (277)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Role of IL-33 in inflammation and disease [PDF]

, 2011
Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation.
Miller, Ashley M.
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]

, 2013
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A, Lund, Sean, Walford, Hannah H   +2 more
core   +2 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Effect of surgical treatment on the cellular immune response of gastric cancer patients

Brazilian Journal of Medical and Biological Research, 2003
Patients with gastric cancer have a variety of immunological abnormalities. In the present study the lymphocytes and their subsets were determined in the peripheral blood of patients with gastric cancer (N = 41) both before and after surgical treatment ...
Barbieri C., Fujisawa M.M., Yasuda C.L., Metze I.L., Oliveira E.C., Santos L.M.B., Lopes L.R., Andreollo N.A.   +7 more
doaj  

Origin of lymph node-derived lymphocytes in human hepatic allografts [PDF]

, 1989
Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node.
Chen, K, Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Markus, B, Marrarri, M, Starzl, TE, Zeevi, A   +7 more
core   +1 more source

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor immunity, immunosuppression, or Bystander Sentinels in Disease? [PDF]

, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or ...
Adachi, Ager, Ager, Aloisi, Andrian von, Ansel, Attridge, Avram, Banks, Bell, Bento, Bergomas, Bombardieri, Browning, Buckley, Bénézech, Calcinotto, Carragher, Carrega, Cañete, Chai, Chen, Cipponi, Colbeck, Coles, Contractor, Coppola, Coronella, de Chaisemartin, De Togni, Deteix, Di Caro, Dieu-Nosjean, Dieu-Nosjean, Drayton, Drayton, Eberl, Fan, Fava, Figenschau, Finkin, Foo, Furman, Furtado, Furtado, Förster, Galkina, Gallimore, Gantsev, García-Hernández, Gardner, Gatumu, Germain, Giraldo, Girard, Gobert, Goc, Goc, Gopal, Gräbner, Gu-Trantien, Hamanishi, Hindley, Hiraoka, Hjelmström, Johansson-Percival, Jones, Joshi, Joyce, Katakai, Kirk, Klages, Kocks, Kratz, Kroeger, Ladányi, Lee, Li, Liao, Lochner, Low, Lu, Luther, Luther, Luther, Marinkovic, Martinet, Martinet, Martinet, McMahon, McMullen, Mebius, Mebius, Mebius, Mebius, Meier, Messina, Motallebzadeh, Moussion, Moyron-Quiroz, Moyron-Quiroz, Muramatsu, Neyt, Nielsen, Nishikawa, Nzula, Ohl, Onder, Peske, Peters, Picker, Pitzalis, Randall, Randolph, Rangel-Moreno, Rangel-Moreno, Remark, Rennert, Roozendaal, Rosen, Ruddle, Sakaguchi, Sakai, Sawa, Scheu, Schmutz, Schneider, Schrama, Schrama, Scurr, Seleznik, Shields, Song, Stranford, Sun, Suzuki, Takatori, Teng, van de Pavert, van de Pavert, van de Pavert, Vermeij, Vondenhoff, Walter, Weinstein, Wengner, Winter, Yokota, Yoshida, Yoshida, Yoshida, Yu   +151 more
core   +5 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease [PDF]

, 2005
Immune reactions against microorganisms play an important pathogenic role in Adamantiades-Behçet’s disease (ABD). We had previously obtained Streptococcus sanguinis (strain BD113-20) isolated from the oral cavity of patients with ABD.
Aoki, Aridogan, Bowden, Celet, Direskeneli, Direskeneli, Doran, Emiko Isogai, Frandsen, Frassanito, Hiroshi Isogai, Hiroshi Ohtsuki, Isogai, Katsantonis, Keiji Oguma, Kenji Yokota, Lehner, Mantas, Martin, Misumi, Raziuddin, Sakane, Sugi-Ikai, Tomomi Kurauchi, Toshihiko Matsuo, Turan, Wanahita, Yokota, Yokota, Yoshihito Fujinami, Zouboulis   +30 more
core   +1 more source