Results 121 to 130 of about 269,589 (144)

The regulatory network that controls the differentiation of T lymphocytes

Biosystems, 2013
There is a vast amount of molecular information regarding the differentiation of T lymphocytes, in particular regarding in vitro experimental treatments that modify their differentiation process. This publicly available information was used to infer the regulatory network that controls the differentiation of T lymphocytes into CD4(+) and CD8(+) cells ...
Luis Mendoza, Pablo Martínez-Sosa
openaire   +3 more sources

Development of Thymic Regulatory T Lymphocytes

2019
A healthy immune system should maintain a balance between the ability to respond to infectious agents and tumor cells at the same time that sustains self-tolerance. For this purpose, the immune system must be capable of restraining foreign antigens, stopping the immune response after the resolution of a problem and blocking autoreactivity of immune ...
Arnon Dias Jurberg, Vinicius Cotta-de-Almeida, João Ramalho Ortigão-Farias, Rafaella Ferreira-Reis, Larissa Vasconcelos-Fontes   +4 more
openaire   +2 more sources

Regulatory substances produced by lymphocytes—IV

Immunochemistry, 1975
Abstract Rat lymphotoxin (LT), a soluble mediator which kills L cells (mouse fibroblasts) within 48 hr, was partially purified by conventional protein fractionation procedures from the culture supernatants of rat lymph node cells stimulated with ovalbumin in vivo and rechallenged with the same antigen in vitro.
Yuziro Namba, Byron H. Waksman
openaire   +5 more sources

Role of Regulatory T Lymphocytes in Health and Disease [PDF]

, 2020
T cells are conventionally categorized into two basic types, viz., CD4+ helper and CD8+ cytotoxic T cells. CD4+ T cells were known to “help” in the activation and differentiation of various immune cells such as NK cells, macrophages, and dendritic cells, whereas CD8+ T cells were known to kill foreign antigens.
Niti Shokeen, Zaffar Azam, Ayaan Ahmad, Asha Bhardwaj, Leena Sapra, Chaman Saini, Rupesh K. Srivastava   +6 more
openaire   +1 more source

Regulatory Role of T Lymphocytes in Atopic Dermatitis

2008
Eczema does not occur in the absence of T cells. Here we provide an overview on the regulatory impact which T cells have on the establishment and maintenance of atopic dermatitis. Particularly, we outline the role of different T-helper cell subsets (i.e.
Thomas Werfel, Miriam Wittmann
openaire   +3 more sources

Perspectives on the regulatory biology of the B lymphocyte

Folia Microbiologica, 1985
B lymphocytes with receptors specific for a particular hapten have been prepared through an antigen-affinity procedure. Methods have been developed for the clonal stimulation of these cells in vitro, with a single, hapten-specific B cell as the unequivocal target.
openaire   +3 more sources

Regulatory T lymphocytes in traumatic brain injury

Neurochemistry International
Traumatic brain injury (TBI) presents a significant global health challenge with no effective therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a potential therapy due to their critical roles in maintaining immune homeostasis, reducing inflammation, and promoting brain repair.
Jiajing Shan, Ruyu Shi, Rimi Hazra, Xiaoming Hu   +3 more
openaire   +2 more sources

Regulatory function of human CD4+ cytolytic T lymphocytes

Transplant Immunology, 1999
Allograft rejection is mediated by both CD4+ and CD8+ T cells. The lytic function of the classic CD8+ cytolytic T lymphocytes (CTL) occurs through recognition of allogeneic major histocompatibility complex (MHC) class I on the surface of the graft. CD4+ CTL recognize MHC class II through a direct recognition pathway or an indirect pathway where MHC ...
Nancy J. Poindexter, Arthur E Haynes, Michael A. Smith, T. Mohanakumar   +3 more
openaire   +3 more sources

Regulatory Lymphocytes in T Cell Functions in Chickens

1977
Our contemporary understanding of the immune system involves the concept of two distinct expressions of immunity as well as the division of lymphocyte types into functional subpopulations. Inherent in the development of this complexity is the discernment that some form of control mechanism must have evolved simultaneously.
openaire   +3 more sources

Role of α-fetoprotein in differentiation of regulatory T lymphocytes

Doklady Biological Sciences, 2017
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells.
Valery A. Chereshnev, Valery A. Chereshnev, S. A. Zamorina, P. V. Khramtsov, M. S. Bochkova, V. P. Timganova, Maria Kropaneva, M. B. Raev, M. B. Raev   +8 more
openaire   +3 more sources