Results 261 to 270 of about 807,016 (349)

Correlation Between Fecal Microbiota and Corticosteroid Responsiveness in Primary Immune Thrombocytopenia: an Exploratory Study

Advanced Science, EarlyView.
This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu, Zhuo‐Yu An, Li‐Juan Cui, Meng‐Yu Xiao, Ye‐Jun Wu, Wei Li, Bang‐Shuo Zhang, Li Yu, Jia Feng, Zhuo‐Gang Liu, Ru Feng, Zhong‐Xing Jiang, Rui‐Bin Huang, Hong‐Mei Jing, Jin‐Hai Ren, Xiao‐Yu Zhu, Yun‐Feng Cheng, Yu‐Hua Li, He‐Bing Zhou, Da Gao, Yi Liu, Fan Yu, Xin Wang, Jian‐Lin Qiao, Dai‐Hong Hu, Lu‐Lu Wang, Meng‐Tong Zang, Qi Chen, Qing‐Yuan Qu, Jian‐Ying Zhou, Meng‐Lin Li, Yu‐Xiu Chen, Qiu‐Sha Huang, Hai‐Xia Fu, Yue‐Ying Li, Qian‐Fei Wang, Xiao‐Jun Huang, Xiao‐hui Zhang, the Cooperative ITP Working Group   +38 more
wiley   +1 more source

Cellular sentinels: empowering survival and immune defense in hematopoietic stem cell transplantation through mesenchymal stem cells and T lymphocytes. [PDF]

BMC Med
Tai TS, Chen YH, Yao CL, Lin JH, Yang YS, Shi JW, Fang LW, Hsu DW, Kuo SC, Hsu SC.   +9 more
europepmc   +1 more source

An Anti‐CD147 Antibody−Drug Conjugate Mehozumab‐DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey

Advanced Science, EarlyView.
Antibody‐drug conjugates are among the fastest‐growing drugs in oncology. It combines the potent killing activity of small molecular drugs and the high specific targeting of antibody drugs. Our in vitro and in vivo studies suggest that anti‐CD147 ADC Mehozumab‐DM1 potently inhibits hepatocellular carcinoma, and combining CD147‐ADCs and targeted therapy
Wan Huang, Liping Zhong, Ying Shi, Qingzhi Ma, Xiangmin Yang, Hongmei Zhang, Jing Zhang, Ling Wang, Kun Wang, Jingzhuo Li, Jie Zou, Xu Yang, Liu Yang, Qingmei Zeng, Lin Jing, Zhi‐Nan Chen, Yongxiang Zhao   +16 more
wiley   +1 more source

The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses. [PDF]

Front Pharmacol
Kiprina A, Teichmann T, Martín Giménez VM, Xu W, Sailer F, Windbergs M, Manucha W, Weigert A, Brandes RP.   +8 more
europepmc   +1 more source

Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck Cancer

Advanced Science, EarlyView.
This study introduces a tumor‐targeted nanomicelle platform (preS1‐pHLIP) that exploits pre‐existing antiviral immunity to combat heterogeneous cancers. By delivering viral antigens to label tumors as virus‐like targets, the nanomicelles activate antiviral B and T cells, triggering in situ tumor lysis.
Lizhuo Zhang, Qingqing Feng, Chuanming Zheng, Yuanqiang Li, Xinyang Ge, Tiefeng Jin, Gaofeng Hu, Zhuo Tan, Jiafeng Wang, Jiajie Xu, Liehao Jiang, Dan Wang, Zhangguo Ying, Xiao Zhao, Keman Cheng, Qinglin Li, Minghua Ge   +16 more
wiley   +1 more source

The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype. [PDF]

J Psychiatry Neurosci
Wang P, Jiang L, Hu J, Jiang Z, Zhang Y, Chen C, Lin Y, Su M, Wang X, Liao L.   +9 more
europepmc   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes.

, 1978
Arthur H. Hale, Owen N. Witte, David Baltimore, Herman N. Eisen   +3 more
openalex   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer. [PDF]

Nat Commun
Stary V, Pandey RV, List J, Kleissl L, Deckert F, Kabiljo J, Laengle J, Gerakopoulos V, Oehler R, Watzke L, Farlik M, Lukowski SW, Vogt AB, Stary G, Stockinger H, Bergmann M, Pilat N.   +16 more
europepmc   +1 more source