Results 91 to 100 of about 113,183 (266)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A New Perspective on Generalized Statistical Convergence of Double Sequences in Neutrosophic 2-Normed Spaces

Transactions on Fuzzy Sets and Systems
In this paper, we study key characteristics of (λ, µ)-statistical convergence within the neutrosophic 2- norm framework. To deepen the understanding of these concepts, we extend our discussion to [V, λ, µ]-summability under ...
Nesar Hossain, Rahul Mondal
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Some fixed point theorems for weakly compatible mappings in Non-Archimedean Menger probabilistic metric spaces via common limit range property

Le Matematiche, 2013
In this paper, we utilize the notion of common limit range property in Non-Archimedean Menger PM-spaces and prove some fixed point theorems for two pairs of weakly compatible mappings. Some illustrative examples are furnished to support our results.
Sunny Chauhan, Jelena Vujakovic
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Definition of Triangular Norms and Triangular Conorms on Subfamilies of Type-2 Fuzzy Sets

Axioms
In certain stages of the application of a type-2 fuzzy logic system, it is necessary to perform operations between input or output fuzzy variables in order to compute the union, intersection, aggregation, complement, and so forth.
Pablo Hernández-Varela, Francisco Javier Talavera, Susana Cubillo, Carmen Torres-Blanc, Jorge Elorza   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sugeno's negations and t-norms

Mathware & soft computing, 1994
A functional characterization of Sugeno's negations is presented and as a consequence, we study a family of non strict Archimedean t-norms whose (vertical-horizontal) sections are straight lines.
openaire   +3 more sources

On the Equational Characterization of Continuous t-Norms

, 2016
A (continuous) t-norm is called equationally definable when the corresponding standard BL-algebra [0,1]∗ defined by ∗ and its residuum is the only (up to isomorphism) standard BL-algebra that generates the same variety Var([0,1]∗). In this chapter we check that a continuous t-norm ∗ is equationally definable if and only if the t-norm is a finite ...
Esteva, Francesc, Godo, Lluis
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source