Results 1 to 10 of about 238,146 (360)

Alu-repeat polymorphism in the tissue plasminogen activator (t-PA) gene, seminal t-PA concentration, and male fertility impairment: A case-control study [PDF]

International Journal of Reproductive BioMedicine, 2020
Background: Tissue plasminogen activator (t-PA) is a protein involved in the fibrinolytic system that catalyzes the conversion of plasminogen into the active plasmin. The activity of t-PA is controlled by plasminogen activator inhibitor-1.
Lubna Hamid Tahtamouni, Mahmoud Nael Hamdan, Zainab Ali Al-Mazaydeh, Randa Mahmoud Bawadi, Majdoleen Sobhi Rammaha, Ahmad Mohammad Zghoul, Mamoun Ahmad Ahram, Salem Refat Yasin   +7 more
doaj   +4 more sources

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors [PDF]

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +3 more sources

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells [PDF]

Journal of Biomedical Science, 2011
Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung, Chen Li-Mien, Kuo Wei-Wen, Lin Yueh-Min, Hu Wei-Syun, Hsu Hsi-Hsien, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang   +9 more
doaj   +5 more sources

Tissue plasminogen activator dose and pulmonary artery pressure reduction in catheter directed thrombolysis of submassive pulmonary embolism. [PDF]

PLoS ONE, 2019
PURPOSE:The purpose of this study is to assess the incremental effect of tissue plasminogen activator (t-PA) dose on pulmonary artery pressure (PAP) and bleeding during catheter directed thrombolysis (CDT) of submassive pulmonary embolism (PE). MATERIALS
Darshan C Patel, Ron C Gaba, Li Liu, R Peter Lokken   +3 more
doaj   +3 more sources

Cardiovascular Risk Associated with Interactions among Polymorphisms in Genes from the Renin-Angiotensin, Bradykinin, and Fibrinolytic Systems [PDF]

, 2010
Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1).
AJ González Ordóñez, AM Thögersen, Amanda Ewart Toland, B Rigat, B Wiman, BK Mahmoodi, C Labinjoh, CA Geluk, Christopher S. Coffey, CJ Skinner, CS Coffey, DE Vaughan, DK Kim, F Cambien, Folkert W. Asselbergs, FW Asselbergs, FW Asselbergs, FW Asselbergs, Hans L. Hillege, J Ruiz, Jason H. Moore, JC Verhave, JH Moore, John P. Bentley, JS Pankow, K Minai, LW Hahn, M Margaglione, MD Ritchie, MJ Pencina, NJ Brown, NJ Brown, NJ Brown, O Saksela, P Eriksson, Patricia R. Hebert, PM Ridker, PS Wells, S Dawson, SE Borggreve, SJ Dawson, SJ Pinto-Sietsma, TA Gerds, Wiek H. van Gilst   +43 more
core   +20 more sources

SOME FIBRINOLYTIC PARAMETERS IN CORONARY ARTERY DISEASE PATIENTS: FOCUS ON UNSTABLE ANGINA SUBGROUPS

Східноукраїнський медичний журнал, 2021
Background and aim. Unstable angina is classified into new-onset, progressive, and angina at rest. Though hemostasis plays a crucial role in the pathogenesis of coronary artery disease, including unstable angina, limited data exist regarding ...
Y. V. Tyravska, O. M. Bondarchuk, N. G. Raksha, V. G. Lizogub, O. M. Savchuk   +4 more
doaj   +1 more source

Future Directions for Active Matter on Ordered Substrates [PDF]

EPL 139, 27001 (2022), 2022
Active matter is a term encompassing particle-based assemblies with some form of self-propulsion, including certain biological systems as well as synthetic systems such as artificial colloidal swimmers, all of which can exhibit a remarkable variety of new kinds of nonequilibrium phenomena.
arxiv   +1 more source

Phosphorylation of human plasminogen activators and plasminogen [PDF]

FEBS Letters, 1995
Plasminogen (PG), urokinase‐type plasminogen activator (u‐PA) and tissue‐type PA (t‐PA) are the main molecules involved in fibrinolysis and in many other physiological and pathological processes. In the present study we report that human t‐PA, purified from human melanoma cells, and PG, purified from human plasma, both contain P‐Tyr residues, as ...
BARLATI, Sergio, DE PETRO, Giuseppina, BONA C, PARACINI F, TONELLI M.   +4 more
openaire   +4 more sources

Plasminogen activator inhibitors [PDF]

Blood, 1987
Chemicals/CAS: fibrin, 9001-31-4; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; Carrier Proteins; Glycoproteins; Plasminogen Activators, EC 3.4.21.-; Plasminogen Inactivators; Protease Inhibitors; protease ...
ED Sprengers, C Kluft
openaire   +4 more sources

Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers

Clinical and Applied Thrombosis/Hemostasis, 2020
The association between severity of fibrinolysis, ascertained by rotational thromboelastometry to diagnose hyperfibrinolysis in patients with out-of-hospital cardiac arrest (OHCA), and conventional fibrinolysis markers (ie, tissue-plasminogen activator ...
Tomoyo Saito MD, PhD, Mineji Hayakawa MD, PhD, Yoshinori Honma MD, Asumi Mizugaki MD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD   +7 more
doaj   +1 more source