Results 81 to 90 of about 241,524 (360)

Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

The Ukrainian Biochemical Journal, 2018
The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-I), in patients with stage ...
O. I. Yusova, O. V. Savchuk, T. V. Grinenko, O. B. Kuchmenko, L. S. Mhitaryan, O. H. Kupchins’ka, I. N. Yevstratova, O. O. Matova, N. M. Vasilinchuk, T. F. Drobot’ko   +9 more
doaj   +1 more source

Profibrinolytic effect of the epigenetic modifier valproic acid in man. [PDF]

PLoS ONE, 2014
AIMS: The aim of the study was to test if pharmacological intervention by valproic acid (VPA) treatment can modulate the fibrinolytic system in man, by means of increased acute release capacity of tissue plasminogen activator (t-PA) as well as an altered
Ott Saluveer, Pia Larsson, Wilhelm Ridderstråle, Thórdís J Hrafnkelsdóttir, Sverker Jern, Niklas Bergh   +5 more
doaj   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease

Brain Sciences, 2019
Cerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood−brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under ...
Larisa A. Dobrynina, Alla A. Shabalina, Maryam R. Zabitova, Elena I. Kremneva, Zukhra Sh. Gadzhieva, Marina V. Krotenkova, Elena V. Gnedovskaya, Alexander B. Berdalin, Lyudmila A. Kalashnikova   +8 more
doaj   +1 more source

SARS‐CoV‐2 infection results in upregulation of Plasminogen Activator Inhibitor‐1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity

eJHaem, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection results in coagulation activation although it is usually not associated with consumption coagulopathy. D‐dimers are also commonly elevated despite systemic hypofibrinolysis.
Kevin H. Toomer, Gloria F. Gerber, Yifan Zhang, Laetitia Daou, Michael Tushek, Jody E. Hooper, Ivo M. B. Francischetti   +6 more
doaj   +1 more source

Associations of Hemostatic Variables with Cardiovascular Disease and Total Mortality: The Glasgow MONICA Study

TH Open, 2022
The associations of plasma levels of hemostatic factors, other than fibrinogen, with risks of cardiovascular disease (CVD) and all-cause mortality are not well defined. In two phases of the Glasgow MONICA study, we assayed coagulation factors (VII, VIII,
Gordon D. O. Lowe, Sanne A. E. Peters, Ann Rumley, Hugh Tunstall-Pedoe, Mark Woodward   +4 more
doaj   +1 more source

Different effects of oral and transdermal hormone replacement therapies on Factor IX, APC resistance, t-PA, PAI and C- reactive protein - a cross-sectional population survey [PDF]

, 2001
The effects of hormone replacement therapy (HRT) on thrombosis risk, thrombotic variables, and the inflammatory marker C- reactive protein (CRP) may vary by route of administration (oral versus transdermal).
Lowe, G.D.O., McConnachie, A., O'Reilly, D.S., Rumley, A., Upton, M.N., Watt, G.C.M.   +5 more
core  

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

The role of thrombophilia genes in the clinical implementation of arterial and venous thrombosis in newborns

BIO Web of Conferences, 2020
The article considers the analysis results of the occurrence frequency of genotypes and alleles of plasma, platelet and fibrinolytic hemostasis in full-term newborns with arterial and venous thrombosis of various localization.
Filippova O. A., Vakhlova I. V., Tsaur G. A., Kuznetsov N. N., Abolina T. B.   +4 more
doaj   +1 more source

Plasminogen–receptor KT: plasminogen activation and beyond [PDF]

Journal of Thrombosis and Haemostasis, 2017
The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-RKT, a key plasminogen receptor expressed in numerous tissues, but highly expressed by ...
Matthew J. Flick, Thomas H. Bugge
openaire   +3 more sources