Results 31 to 40 of about 1,654,677 (246)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells
The Journal of Clinical Investigation, 2022 The functional integrity of CD8+ T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs CD8+ T cell metabolic fitness in the tumor microenvironment (TME) remains elusive.
Zhongqiu Wu +10 more
doaj +1 more source
Frontiers in Plant Science, 2020 Drought and heat stresses are two major environmental stress factors that severely threaten crop growth and productivity. Plant delay of germination 1-like (DOG1L) family genes play important roles in various developmental processes and stress responses.
Xiaoyan Dai +9 more
doaj +1 more source
Energies, 2022 Based on the existing research results, a theoretical fracture model of strata under the compound impact of static and harmonic dynamic load is improved, and the fracture characteristic parameters (stress intensity factor, T-stress, and fracture ...
Haiping Zhang +5 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Renmin Zhujiang, 2020 The traditional theory of fracture mechanics only considers the singular stress term in the Williams expansion term of the stress field at the crack tip.There is a big difference between the theoretical predicted value and the experimental value of the ...
JIN Songyang, LIU Hui
doaj
Applied Sciences, 2022 The Urumqi area in China is a seasonally cold region, and the rock structures in the region are susceptible to freeze-thaw (F-T) weathering. Therefore, this study investigated the effect of F-T on the physical, mechanical, and fracture behavior of ...
Junce Xu, Hai Pu, Ziheng Sha
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
T-stress of Concrete under Four-point Bending
Proceedings of the 9th International Conference on Fracture Mechanics of Concrete and Concrete Structures, 2016 Mixed mode stress-intensity factors (SIFs) and the T-stress for different geometries of four-point bending specimens were calculated by means of finite element analysis through a software suite Abaqus, where the influence of the loading point and crack location were considered.
Zhao Yanhua, Liu Jin
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source