Results 81 to 90 of about 1,654,677 (246)
Forces in MechanicsThis study focuses on less-studied mode I/III fracture cracking behaviour. Seven specimens (ENDC, DNDC, SCB, ENDB, ATPB, TPB-IC, and SENB) were analyzed numerically and experimentally. Results show in pure mode-I, the specimens show identical KIc values (
Amir Mousavi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Positive Role of Trichoderma harzianum in Increasing Plant Tolerance to Abiotic Stresses: A Review
AntioxidantsAs a beneficial fungus, Trichoderma harzianum (T. harzianum) has been widely applied for growth promotion and biocontrol. Recently, it has attracted much attention with regard to improving stress tolerance in plants under abiotic stress.
Yueyao Geng +8 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Influence of T-stress on fatigue crack propagation
, 2015 Mechanical components of aircraft may suffer from shocks and scratches during their and assembly. Under service, these structures are subjected to fatigue loading. This might lead to the initiation of micro-cracks, which will propagate, and in the worst cases, the fracture of the component might occur.
Brugier, François +2 more
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Current Plant BiologyDrought stress in hemp (Cannabis sativa L.) is exacerbated by climate change, posing significant abiotic challenges. Trichoderma hamatum, known for mitigating abiotic stresses, was evaluated for its effects on hemp under drought conditions.
Byeong-Ryeol Ryu +7 more
doaj +1 more source