Results 91 to 100 of about 23,474 (264)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Properties of the solution map for a first order linear problem

Electronic Journal of Differential Equations, 2001
We are interested in establishing properties of the general mathematical model $$frac{dvec{u}}{dt}=T(t,vec{u})+vec{b}+vec{g}(t),quad vec{u}(t_0)=vec{u}_0 $$ for the dynamical system defined by the (possibly nonlinear) operator $T(t,cdot):Vo V$ with state
James L. Moseley
doaj  

On General multilinear square function with non-smooth kernels

, 2015
In this paper, we obtain some boundedness of the following general multilinear square functions $T$ with non-smooth kernels, which extend some known results significantly. $$ T(\vec{f})(x)=\big( \int_{0}^\infty \big|\int_{(\mathbb{R}^n)^m}K_v(x,y_1,\dots,
Hormozi, Mahdi, Si, Zengyan, Xue, Qingying   +2 more
core  

Rotation of Crystal Seed During Early Stages of Growth Reveals the Anisotropy of Glass Matrix

Advanced Science, EarlyView.
Molecular dynamics simulations reveal that crystal seeds can spontaneously rotate within glass at high temperatures due to anisotropic forces at the glass‐crystal interface. This rotation challenges the long‐held view of glass as an isotropic solid and highlights how atomic‐scale inhomogeneities can influence crystal growth and microstructure of LiNbO3‐
R. Thapa, E. J. Musterman, H. Jain, V. Dierolf, M. E. McKenzie   +4 more
wiley   +1 more source

Single-cell analysis of oncolytic virotherapy in adult T-cell leukemia/lymphoma

Journal for ImmunoTherapy of Cancer
Adult T-cell leukemia/lymphoma (ATLL), an aggressive T-cell malignancy associated with human T-cell leukemia virus type 1, presents significant therapeutic challenges due to high relapse rates and resistance to therapy.
Qiang Liu, Yanhua Wang, Yang Shi, Amit Verma, Qing Wang, Wei Cai, Wenjun Deng, Haiying Cheng, Rafi Kabarriti, Jianhong An, Erqiang Hu, Yanan Fang, Naijia Liu, Wu He, Angelina Wang, Yinghui Song, Jidong Shan, Jinghang Zhang, Yiyu Zou, Roberto Alejandro Sica, Shanye Yin   +20 more
doaj   +1 more source

Overcoming the Trade‐Off Between Magnetic Coupling and Electrical Insulation in Soft Magnetic Materials via Nanochain Engineering

Advanced Science, EarlyView.
This study employs a nanochain engineering approach combined with an in situ oxidation strategy to fabricate self‐insulating iron‐based magnetic nanochains, addressing the challenge of balancing magnetic coupling and electrical insulation in soft magnetic materials.
Dingrong Zuo, Lichen Liu, Haibo Ke, Rongsheng Bai, Huaping Ding, Jing Zhou, Zhenxiang Cheng, Peng Yu, Weihua Wang   +8 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

N-Acetylcysteine and Sulodexide Reduce the Prothrombotic Effect of Uremic Serum on the Venous Endothelial Cells

Kidney & Blood Pressure Research, 2019
Background/Aims: Thromboembolic episodes are a frequent problem in end stage renal failure patients. The pathomechanism of the disorder is complex, including bioincompatibility of renal replacement therapy, endothelial dysfunction, increased blood level ...
Patrycja Sosinska-Zawierucha, Beata Mackowiak, Andrzej Breborowicz   +2 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Deep Learning without Poor Local Minima [PDF]

, 2016
In this paper, we prove a conjecture published in 1989 and also partially address an open problem announced at the Conference on Learning Theory (COLT) 2015.
Kawaguchi, Kenji
core   +1 more source