Results 91 to 100 of about 12,032,280 (304)

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, EarlyView.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source

Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection

Frontiers in Immunology, 2012
Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global becoming a new worldwide challenge. For more than a century since its discovery, it has remained neglected with no effective drugs or vaccines.
Pius N. Nde, Maria F Lima, Candice A Johnson, Siddharth ePratap, Fernando eVillalta   +4 more
doaj   +1 more source

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source

Landmarks of the Knowledge and Trypanosoma cruzi Biology in the Wild Environment

Frontiers in Cellular and Infection Microbiology, 2020
Trypanosomatids are ancient parasitic eukaryotes that still maintain prokaryotic characteristics. Trypanosoma cruzi, a primarily wild mammal parasite, infected humans already long before European colonization of the Americas. T.
A. Jansen, S. Xavier, A. L. R. Roque
semanticscholar   +1 more source

FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Preterm birth (PTB) remains one of the leading causes of neonatal mortality and long‐term morbidity worldwide, with minimal progress being made in reducing its incidence, particularly in low‐resource settings. Preconception care is recognized as an effective strategy for PTB prevention; however, the fact that more than half of pregnancies ...
Leticia Irma Ojeda, Catalina M. Valencia, Natalia Cardozo Buitrago, Dilly Anumba, Wondimu Gudu, Ana Bianchi, Bo Jacobsson, on behalf of the FIGO Committee for Preterm Birth, Catalina M. Valencia González, Dilly Anumba, Wondimu Gudu, Bo Jacobsson, Nancy Sierra Lozada, Leticia Ojeda, Madhuri Patel, Andrew Shennan, Rodrigo Rigoni, Priya Soma‐Pillay, Sherri Ann Suplido, Ana Daneva, Sikolia Wanyonyi, Haim Abenhaim   +21 more
wiley   +1 more source

Chagas Disease Maternal Seroprevalence and Maternal–Fetal Health Outcomes in a Parturition Cohort in Western El Salvador

Tropical Medicine and Infectious Disease, 2023
Congenital Chagas disease is a growing concern, prioritized by the World Health Organization for public health action. El Salvador is home to some of the highest Chagas disease (Trypanosoma cruzi infection) burdens in the Americas, yet pregnancy ...
Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Mufaro Kanyangarara, Stella C. W. Self, Berry A. Campbell, Melissa S. Nolan   +6 more
doaj   +1 more source

Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. [PDF]

, 2011
The single celled eukaryote Trypanosoma cruzi, a parasite transmitted by numerous species of triatomine bug in the Americas, causes Chagas disease in humans. T.
Acosta, N., Carlton, J.M., Gaunt, M.W., Lewis, M.D., Llewellyn, M.S., Miles, M.A., Yeo, M.   +6 more
core   +4 more sources

Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

Frontiers in Cellular and Infection Microbiology, 2020
Extracellular vesicles (EVs) shed by trypomastigote forms of Trypanosoma cruzi have the ability to interact with host tissues, increase invasion, and modulate the host innate response. In this study, EVs shed from T. cruzi or T.cruzi-infected macrophages
A. Cronemberger-Andrade, P. Xander, R. Soares, N. L. Pessoa, M. A. Campos, Cameron C Ellis, Brian Grajeda, Yifat Ofir-Birin, I. Almeida, Neta Regev-Rudzki, A. Torrecilhas   +10 more
semanticscholar   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

DNA content analysis allows discrimination between Trypanosoma cruzi and Trypanosoma rangeli. [PDF]

PLoS ONE, 2017
Trypanosoma cruzi, a human protozoan parasite, is the causative agent of Chagas disease. Currently the species is divided into six taxonomic groups.
Lucila Langoni Naves, Marcos Vinícius da Silva, Emanuella Francisco Fajardo, Raíssa Bernardes da Silva, Fernanda Bernadelli De Vito, Virmondes Rodrigues, Eliane Lages-Silva, Luis Eduardo Ramírez, André Luiz Pedrosa   +8 more
doaj   +1 more source