Results 71 to 80 of about 10,211,329 (187)

Caracterização biológica e molecular de cepas de Trypanosoma cruzi isoladas durante o surto de doença de Chagas agudo em Santa Catarina: [dissertação] [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biotecnologia, Florianópolis, 2010Estudos moleculares e de biologia demonstram que o táxon Trypanosoma cruzi é composto por ...
Pena, Darlene Aparecida
core  

Biological Evaluation, Molecular Docking, MD Simulation Study and Synthesis of (Z)‐N’‐(3‐phenoxybenzylidene)‐2‐(substituted‐amino aryl) Acetohydrazid

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Synthesis and biological evaluation (antibacterial, antifungal, anti‐tuberculosis, antiprotozoal) and in silico molecular docking of biphenyl ether based Schiff's base analogues. ABSTRACT In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2‐(substituted‐arylamino)‐N′‐(3 ...
Navin B. Patel, Deepti S. Ghaisas, Vatsal M. Patel, Faiyazalam M. Shaiikh, Mohit Agrawal, Mohd Imran, Gildardo Rivera, Hetal I. Soni   +7 more
wiley   +1 more source

Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology.

, 2010
Chagas disease, marked by life-long chronic infection with Trypanosoma cruzi, remains a major parasitic disease in Latin America. Genetically heterogeneous, T. cruzi is divided into six discrete typing units (DTUs), most recently grouped as TcI-VI.
Carrasco, Hernan J, Llewellyn, Martin S, Yeo, Matthew, Miles, Michael A, Lewis, Michael D, Bhattacharyya, Tapan, Brooks, Jessica   +6 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Javier M. Urquiza, Javier M. Urquiza, Juan M. Burgos, Juan M. Burgos, Diego S. Ojeda, Diego S. Ojeda, Carla A. Pascuale, Carla A. Pascuale, M. Susana Leguizamón, M. Susana Leguizamón, Jorge F. Quarleri, Jorge F. Quarleri   +11 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Exploring Trypanosoma cruzi transmission dynamics in an acute Chagas disease outbreak using next-generation sequencing

Parasites & Vectors
Background Chagas disease (CD), caused by Trypanosoma cruzi, poses a major global public health challenge. Although vector-borne transmission is the primary mode of infection, oral transmission is increasingly concerning. Methods This study utilized long-
Lissa Cruz-Saavedra, Carlos Ospina, Stivenn A. Gutiérrez, Jeiczon Jaimes-Dueñez, Omar Cantillo-Barraza, Carolina Hernández, Francisco Álvarez, María Blanco, Bernardo Leal, Lida Martínez, Manuel Medina, Mabel Medina, Silvia Valdivieso, Lauren Natalia Ramirez Celis, Luz H. Patiño, Juan David Ramírez   +15 more
doaj   +1 more source

Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru.

PLoS Neglected Tropical Diseases, 2015
BackgroundVector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and
Karen A Alroy, Christine Huang, Robert H Gilman, Victor R Quispe-Machaca, Morgan A Marks, Jenny Ancca-Juarez, Miranda Hillyard, Manuela Verastegui, Gerardo Sanchez, Lilia Cabrera, Elisa Vidal, Erica M W Billig, Vitaliano A Cama, César Náquira, Caryn Bern, Michael Z Levy, Working Group on Chagas Disease in Peru   +16 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado, Gerardo M. Ojeda‐Carralero, Mario Antonio Rodríguez, Isabella Rúa, Heisy Guerra, Edoardo Bailo Hernández, Guglielmo Coppola, Susana Alberti, Ariatne Rodríguez, Maikel Izquierdo, Christian Betzel, Filippo Pettazzi, Julieta Coro‐Bermello, Erik V. Van der Eycken, Bernhard Westermann, Jorge González‐Bacerio, Daniel G. Rivera   +16 more
wiley   +1 more source