Results 71 to 80 of about 42,346 (181)

Identification and lineage genotyping of South American trypanosomes using fluorescent fragment length barcoding.

, 2011
Trypanosoma cruzi and Trypanosoma rangeli are human-infective blood parasites, largely restricted to Central and South America. They also infect a wide range of wild and domestic mammals and are transmitted by a numerous species of triatomine bugs. There
S.A. Valente, HAMILTON, P. B., C. Cruickshank, Cruickshank, C, YEO, M., Hamilton, PB, M.S. Llewellyn, GAUNT, M. W., LEWIS, M. D., Yeo, M, M. Yeo, SILVA, F. Maia da, F. Maia da Silva, MILES, M. A., Stevens, JR, J.R. Stevens, M.W. Gaunt, VALENTE, S. A., LLEWELLYN, M. S., Gaunt, MW, P.B. Hamilton, Lewis, MD, Llewellyn, MS, Miles, MA, Teixeira, MMG, TEIXEIRA, M. M. G., Maia da Silva, F, STEVENS, J. R., CRUICKSHANK, C., M.D. Lewis, M.A. Miles, Valente, SA   +31 more
core   +1 more source

Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2017
The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Javier M. Urquiza, Javier M. Urquiza, Juan M. Burgos, Juan M. Burgos, Diego S. Ojeda, Diego S. Ojeda, Carla A. Pascuale, Carla A. Pascuale, M. Susana Leguizamón, M. Susana Leguizamón, Jorge F. Quarleri, Jorge F. Quarleri   +11 more
doaj   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source

Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru.

PLoS Neglected Tropical Diseases, 2015
BackgroundVector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and
Karen A Alroy, Christine Huang, Robert H Gilman, Victor R Quispe-Machaca, Morgan A Marks, Jenny Ancca-Juarez, Miranda Hillyard, Manuela Verastegui, Gerardo Sanchez, Lilia Cabrera, Elisa Vidal, Erica M W Billig, Vitaliano A Cama, César Náquira, Caryn Bern, Michael Z Levy, Working Group on Chagas Disease in Peru   +16 more
doaj   +1 more source

Analysis of molecular diversity of the Trypanosoma cruzi trypomastigote small surface antigen reveals novel epitopes, evidence of positive selection and potential implications for lineage-specific serology.

, 2010
Chagas disease, marked by life-long chronic infection with Trypanosoma cruzi, remains a major parasitic disease in Latin America. Genetically heterogeneous, T. cruzi is divided into six discrete typing units (DTUs), most recently grouped as TcI-VI.
Carrasco, Hernan J, Llewellyn, Martin S, Yeo, Matthew, Miles, Michael A, Lewis, Michael D, Bhattacharyya, Tapan, Brooks, Jessica   +6 more
core   +1 more source

Electro‐Mechanical Dissociation in Chagas Cardiomyopathy: Comparative Analysis of Arrhythmic Burden Beyond LVEF

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Despite matched clinical characteristics and LVEF, patients with Chagas cardiomyopathy exhibit a significantly higher arrhythmic burden compared to ischemic cardiomyopathy. This electro‐mechanical dissociation highlights the necessity of sudden death risk stratification strategies that extend beyond traditional ejection fraction thresholds.
Luis E. Echeverría, Lyda Z. Rojas, Angie Yarlady Serrano‐García, Yina T. Ariza, Carlos Luengas, Rachel Marcus, Carlos A. Morillo, Sergio A. Gómez‐Ochoa   +7 more
wiley   +1 more source

Exploring Trypanosoma cruzi transmission dynamics in an acute Chagas disease outbreak using next-generation sequencing

Parasites & Vectors
Background Chagas disease (CD), caused by Trypanosoma cruzi, poses a major global public health challenge. Although vector-borne transmission is the primary mode of infection, oral transmission is increasingly concerning. Methods This study utilized long-
Lissa Cruz-Saavedra, Carlos Ospina, Stivenn A. Gutiérrez, Jeiczon Jaimes-Dueñez, Omar Cantillo-Barraza, Carolina Hernández, Francisco Álvarez, María Blanco, Bernardo Leal, Lida Martínez, Manuel Medina, Mabel Medina, Silvia Valdivieso, Lauren Natalia Ramirez Celis, Luz H. Patiño, Juan David Ramírez   +15 more
doaj   +1 more source

Estudo da interação celular parasito-hospedeiro a partir da expressão heteróloga de trans-sialidase de Trypanosoma cruzi por Trypanosoma rangeli em ensaios in vitro e in vivo [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biotecnologia e Biociências, Florianópolis, 2013As trans-sialidades de Trypanosoma cruzi (TcTS) são capazes de clivar resíduos de
Granucci, Ninna
core  

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Interaction of Trypanosoma cruzi, Triatomines and the Microbiota of the Vectors—A Review

Microorganisms
This review summarizes the interactions between Trypanosoma cruzi, the etiologic agent of Chagas disease, its vectors, triatomines, and the diverse intestinal microbiota of triatomines, which includes mutualistic symbionts, and highlights open questions.
Günter A. Schaub
doaj   +1 more source