Results 51 to 60 of about 10,211,329 (187)

Toward New Epidemiological Landscapes of Trypanosoma cruzi (Kinetoplastida, Trypanosomatidae) Transmission under Future Human-Modified Land Cover and Climatic Change in Mexico

Tropical Medicine and Infectious Disease, 2022
Chagas disease, caused by the protozoa Trypanosoma cruzi, is an important yet neglected disease that represents a severe public health problem in the Americas.
Constantino González-Salazar, Anny K. Meneses-Mosquera, Alejandra Aguirre-Peña, Karla Paola J. Fernández-Castel, Christopher R. Stephens, Alma Mendoza-Ponce, Julián A. Velasco, Oscar Calderón-Bustamante, Francisco Estrada   +8 more
doaj   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source

Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains.

, 2012
A Multilocus Sequence Typing (MLST) scheme was designed and applied to a set of 20 Trypanosoma cruzi stocks belonging to three main discrete typing units (T. cruzi I, V and VI) from a geographically restricted Chagas disease endemic area in Argentina, 12
Rumi, M. M. M., D'Amato, A. M. A., Barnabé, C., Yeo, Matthew, Lauthier, J.J., Basombrio, M. A., Tomasini, N., Ragone, P.G., Lewis, M. D., Lauthier, Juan J, Miles, M. A., Miles, M.A., Tibayrenc, M., Ragone, P. G., Ragone, Paula G, Yeo, M., Barnabé, Christian, Basombrío, Miguel A, Tibayrenc, Michel, Llewellyn, M. S., Diosque, Patricio, Tomasini, Nicolás, Llewellyn, Martin S, D'Amato, Anahí M Alberti, Miles, Michael A, Lewis, M.D., D’Amato, A.M. A., Rumi, María M Monje, Diosque, P., Lewis, Michael D, Rumi, M.M.M., Lauthier, J. J., Basombrío, M.A., Llewellyn, M.S.   +33 more
core   +1 more source

Putting Rodents at the Center of One Health Programs: A Narrative Synthesis

Integrative Zoology, EarlyView.
Rodents link human, animal, and environmental health across diverse ecosystems. Rodent diversity underpins both zoonotic disease risk and ecosystem function. Environmental change reshapes rodent communities and spillover dynamics. Rodents act as reservoirs, amplifiers, and sentinels of emerging pathogens.
Steven R. Belmain
wiley   +1 more source

The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications.

, 2012
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and
Andrade, S. G., Sturm, N.R., Andrade, S.G., Sturm, N. R., Zingales, B., Macedo, Andrea M, Schijman, Alejandro G, Machado, C. R., Zingales, Bianca Silvana, Andrade, Sonia G, Teixeira, Marta Maria Geraldes, Zingales, Bianca, Macedo, A.M., Machado, C.R., Lages-Silva, E., Miles, M. A., Sturm, Nancy R, Miles, M.A., Schijman, A.G., Andrade, Sonia Gumes, Macedo, A. M., Teixeira, M. M. G., Tibayrenc, M., Campbell, .A., Tibayrenc, Michel, Llewellyn, M. S., Llewellyn, Martin S, Teixeira, M.M.G., Miles, Michael A, Campbell, David A, Campbell, D. A., Macedo, Andrea Mara, Teixeira, Marta MG, Schijman, A. G., Machado, Carlos Renato, Lages-Silva, Eliane, Machado, Carlos R, Llewellyn, M.S., Silva, Eliane Lages   +38 more
core   +1 more source

Different infective forms trigger distinct immune response in experimental Chagas disease. [PDF]

, 2012
Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface.
Olindo Assis Martins-Filho, Carneiro Cláudia Martins, Martins-Filho, Olindo Assis, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Francisco Amanda Fortes, Washington Luiz Tafuri, Carvalho, Andrea Teixeira, Machado Evandro Marques de Meneses, Nogueira, Nívia Carolina, Franscisco, Amanda Fortes, Evandro Marques de Meneses Machado, Vieira, Paula Melo de Abreu, Fonseca, Kátia da Silva, Francisco, Amanda Fortes, Andrea Teixeira-Carvalho, Paula Melo de Abreu Vieira, Nogueira, N??via Carolina, Machado, Evandro Marques de Menezes, Vieira Paula Melo de Abreu, Machado, Evandro Marques de Meneses, Tafuri, Washington Luiz, Reis Alexandre Barbosa, Teixeira-Carvalho Andrea, Reis, Alexandre Barbosa, Martins-Filho Olindo Assis, Nívia Carolina Nogueira, Kátia da Silva Fonseca, Carvalho, Andréa Teixeira de, Nogueira Nívia Carolina, Amanda Fortes Francisco, Tafuri Washington Luiz, Teixeira-Carvalho, Andrea, Carneiro, Cláudia Martins, Martins Filho, Olindo Assis, Fonseca Kátia da Silva   +35 more
core   +2 more sources

Should Trypanosoma cruzi be called "cruzi" complex? A review of the parasite diversity and the potential of selecting population after in Vitro culturing and mice infection

Memorias do Instituto Oswaldo Cruz, 2003
Morpho-biological diversity of Trypanosoma cruzi has been known since Chagas' first works in 1909. Several further studies confirmed the morphological differences among the parasite strains, which were isolated from different reservoirs and vectors, as ...
Devera Rodolfo, Fernandes Octavio, Coura José Rodrigues   +2 more
doaj   +3 more sources

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients. [PDF]

, 2015
BACKGROUND: Chagas disease results from infection with the diploid protozoan parasite Trypanosoma cruzi. T. cruzi is highly genetically diverse, and multiclonal infections in individual hosts are common, but little studied.
Torrico, Faustino, Tavares, Suelene BN, Torrico, F., Louisa A Messenger, Sauer, S., Céline Baulard (718392), Delepine, M., Baulard, Céline, Bachar Cheaib, Deleuze, Jean-Francois, Cheaib, Bachar, Garcia, Lineth, Marc Delepine, Jean-Francois Deleuze, Nicolas Derome (2201653), Luquetti, A.O., Martin S. Llewellyn (155605), Faustino Torrico (102187), Miles, M.A., Messenger, Louisa A, Derome, Nicolas, Louisa A. Messenger (172069), Delepine, Marc, Michael A. Miles (43726), Llewellyn, Martin S, Sauer, Sascha, Martin S Llewellyn, Tavares, S.B.N., Miles, Michael A, Sascha Sauer (271148), Deleuze, J.F., Llewellyn, M.S., Messenger, L.A., Sascha Sauer, Suelene B. N. Tavares (505260), Deleuze, J.-F., Michael A Miles, Alejandro O. Luquetti (505259), Jean-Francois Deleuze (718393), Alejandro O Luquetti, Lineth Garcia, Luquetti, Alejandro O, Cheaib, B., Garcia, L., Nicolas Derome, Lineth Garcia (102146), Céline Baulard, Derome, N., Faustino Torrico, Marc Delepine (184928), Baulard, C., Suelene B N Tavares, Bachar Cheaib (718391)   +52 more
core   +1 more source