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Host defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to several microorganisms, such as ...
Hisako Kayama +11 more
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Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection. [PDF]
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite, Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global insights into the T.
Yuan Li +11 more
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The unlabelled antibody peroxidase-antiperoxidase method was used to study the immunocytochemical properties of Leishmania and Trypanosoma cruzi amastigotes in situ after tissues had been submitted to different fixation procedures. Antisera were obtained
A.J.A. Barbosa +5 more
doaj +3 more sources
Genome size, karyotype polymorphism and chromosomal evolution in Trypanosoma cruzi. [PDF]
BackgroundThe Trypanosoma cruzi genome was sequenced from a hybrid strain (CL Brener). However, high allelic variation and the repetitive nature of the genome have prevented the complete linear sequence of chromosomes being determined.
Renata T Souza +9 more
doaj +1 more source
Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi
The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won +2 more
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Background In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T.
Andrea Alice Silva +7 more
doaj +1 more source
Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics
Chagas disease, caused by Trypanosoma cruzi and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines.
Edem Fiatsonu +2 more
doaj +1 more source
Background In Colombia, Rhodnius prolixus and Triatoma dimidiata are the main domestic triatomine species known to transmit T. cruzi. However, there are multiple reports of T. cruzi transmission involving secondary vectors.
Omar Cantillo-Barraza +7 more
doaj +1 more source
Chagas disease is a public health problem caused by the Trypanosoma cruzi, and the T. cruzi I (TcI) and T. cruzi II (TcII) groups are considered important genotypes from the clinical point of view. Currently, the groups need to be molecularly analyzed for their identification; thus, we cytogenetically analyzed these groups with the objective of ...
De Oliveira, Ana Beatriz Bortolozo +6 more
openaire +4 more sources
Background Chagas disease (caused by Trypanosoma cruzi) is the most important neglected tropical disease (NTD) in Latin America, infecting an estimated 5.7 million people in the 21 countries where it is endemic. It is one of the NTDs targeted for control
Jennifer K. Peterson +3 more
doaj +1 more source

