Results 31 to 40 of about 42,346 (181)

Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses

, 2007
Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested that immature DCs might sense kinin-releasing strains of Trypanosoma cruzi through the triggering ...
Müller-Esterl Werner, Alessandra Granato, Schmitz Verônica, Scharfstein Julio, Tanowitz Herbert B, Scharfstein, Julio, Werner Müller-Esterl, Fnu Nagajyothi, de Arruda Luciana Barros, Nagajyothi, Fnu, Granato Alessandra, Pesquero João B, Müller-Esterl, Werner, Schmitz, Verônica, Luciana Barros de Arruda, Alexandre Morrot, Granato, Alessandra, Barros de Arruda, Luciana, Morrot Alexandre, Monteiro, Ana Carolina, Tanowitz, Herbert B., Julio Scharfstein, Nagajyothi Fnu, Morrot, Alexandre, Verônica Schmitz, João B Pesquero, Pesquero, João B., Monteiro Ana Carolina, Ana Carolina Monteiro, Herbert B Tanowitz   +29 more
core   +1 more source

Trypanosoma cruzi IIc: phylogenetic and phylogeographic insights from sequence and microsatellite analysis and potential impact on emergent Chagas disease. [PDF]

, 2009
Trypanosoma cruzi, the etiological agent of Chagas disease, is highly genetically diverse. Numerous lines of evidence point to the existence of six stable genetic lineages or DTUs: TcI, TcIIa, TcIIb, TcIIc, TcIId, and TcIIe.
Torrico, Faustino, Acosta, Nidia, Torrico, F., Llewellyn Martin S., Nidia Acosta, Acosta Nidia, Jorge Vargas, Carrasco, H.J., Gaunt Michael W., Carrasco, Hernan J, Yeo, Matthew, Michael A Miles, Miles Michael A., Hernan J Carrasco, Gaunt, Michael W, Segovia Maikell, Vargas, Jorge, Torrico Faustino, Yeo Matthew, Miles, M.A., Michael D Lewis, Segovia, M., Yeo, M., Acosta, N., Matthew Yeo, Vargas Jorge, Llewellyn, Martin S, Martin S Llewellyn, Segovia, Maikell, Miles, Michael A, Lewis, M.D., Gaunt, M.W., Faustino Torrico, Lewis, Michael D, Carrasco Hernan J., Vargas, J., Maikell Segovia, Michael W Gaunt, Llewellyn, M.S., Lewis Michael D.   +39 more
core   +1 more source

Distribution and pathogenicity of Trypanosoma cruzi isolated from peridomestic populations of Triatoma infestans and Triatoma guasayana from rural Western Argentina

Memorias do Instituto Oswaldo Cruz, 2005
We assessed the distribution of Trypanosoma cruzi infection in peridomestic triatomines collected manually at a district-wide scale in rural villages around Olta, Western Argentina, and typed the isolated strains according to their pathogenicity to ...
Marta A Lauricella, Raúl L Stariolo, Adelina R Riarte, Elsa L Segura, Ricardo E Gürtler   +4 more
doaj   +1 more source

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. [PDF]

, 2015
BACKGROUND: The neglected parasitic infection Chagas disease is rapidly becoming a globalised public health issue due to migration. There are only two anti-parasitic drugs available to treat this disease, benznidazole and nifurtimox. Thus it is important
Fortes Francisco, A, Martin C Taylor, John M Kelly, Michael D Lewis, Shane R. Wilkinson (721807), Fortes Francisco, Amanda, Amanda Fortes Francisco (330407), Taylor, Martin C, Lewis, MD, Amanda Fortes Francisco, Wilkinson, SR, Michael D. Lewis (172100), Taylor, MC, Lewis, Michael D, Kelly, JM, Shane R Wilkinson, Wilkinson, Shane R, Kelly, John M, Martin C. Taylor (449215), John M. Kelly (488103)   +19 more
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Expressão heteróloga de uma trans-sialidase de Trypanosoma cruzi por Trypanosoma rangeli [PDF]

, 2010
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O Trypanosoma rangeli é um parasito hemoflagelado, com capacidade de infectar animais incluindo o homem, nas Américas Central e do Sul.
Granucci, Ninna
core  

Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids.

, 2005
Trypanosoma cruzi, the causative agent of Chagas disease, has at least two principal intraspecific subdivisions, T. cruzi I (TCI) and T. cruzi II (TCII), the latter containing up to five subgroups (a-e).
González, N., Arias, A. R.de, de Arias, Antonieta Rojas, Acosta, Nidia, González, Nilsa, Miles, M.A., Miles, G.A.J., Patterson, J.S., Sánchez, Humberto, Yeo, M., Patterson, James S, Acosta, N., Sánchez, H., Miles, Graham AJ, Yeo, Matthew, López, Elsa, Miles, Michael A, Gaunt, M.W., López, E., Adamson, Susie, Adamson, S., Gaunt, Michael W, Llewellyn, Martin, Llewellyn, M.S.   +23 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Sex, subdivision, and domestic dispersal of Trypanosoma cruzi lineage I in southern Ecuador. [PDF]

, 2010
BACKGROUND: Molecular epidemiology at the community level has an important guiding role in zoonotic disease control programmes where genetic markers are suitably variable to unravel the dynamics of local transmission. We evaluated the molecular diversity
Mario J Grijalva, Ocaña-Mayorga, Sofía, Michael A. Miles, Jaime A Costales, Miles, M.A., Llewellyn Martin S., Costales Jaime A., Ocaña-Mayorga, S., Martin S. Llewellyn, Costales, J.A., Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Ocaña-Mayorga Sofía, Mario J. Grijalva, Sofía Ocaña-Mayorga, Michael A Miles, Jaime A. Costales, Miles Michael A., Grijalva, Mario J, Costales, Jaime A, Grijalva, M.J., Grijalva Mario J., Llewellyn, M.S.   +23 more
core   +1 more source