Results 21 to 30 of about 42,346 (181)

Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi

mSphere, 2023
The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won, Aaron Baublis, Barbara A. Burleigh   +2 more
doaj   +1 more source

Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

Journal of Neuroinflammation, 2017
Background In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T.
Andrea Alice Silva, Rafael Rodrigues Silva, Daniel Gibaldi, Rafael Meyer Mariante, Jessica Brandão dos Santos, Isabela Resende Pereira, Otacílio Cruz Moreira, Joseli Lannes-Vieira   +7 more
doaj   +1 more source

Genome size, karyotype polymorphism and chromosomal evolution in Trypanosoma cruzi. [PDF]

PLoS ONE, 2011
BackgroundThe Trypanosoma cruzi genome was sequenced from a hybrid strain (CL Brener). However, high allelic variation and the repetitive nature of the genome have prevented the complete linear sequence of chromosomes being determined.
Renata T Souza, Fábio M Lima, Roberto Moraes Barros, Danielle R Cortez, Michele F Santos, Esteban M Cordero, Jeronimo Conceiçao Ruiz, Samuel Goldenberg, Marta M G Teixeira, José Franco da Silveira   +9 more
doaj   +1 more source

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal. [PDF]

, 2015
An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes.
Bustamante, Marinely, Torrico, Faustino, Michael A. Miles, Messenger, L.A., Torrico, F., Marycruz Torrico, Huaranca, Carlos, Huaranca, C., Torrico, Marycruz, Marinely Bustamante, Carlos Huaranca, Garcia, Lineth, Bustamante, M., Louisa A. Messenger, Miles, Michael A., Lineth Garcia, Miles, Michael, Miles, M.A., Mathieu Vanhove, Messenger, Louisa A, Garcia, L., Martin S. Llewellyn, Llewellyn, Martin S, Vanhove, Mathieu, Vanhove, M., Messenger, Louisa A., Miles, Michael A, Faustino Torrico, Llewellyn, Martin, Llewellyn, Martin S., Messenger, Louisa, Llewellyn, M.S., Torrico, M.   +32 more
core   +1 more source

Genotyping of Trypanosoma cruzi: systematic selection of assays allowing rapid and accurate discrimination of all known lineages. [PDF]

, 2009
Trypanosoma cruzi, the agent of Chagas disease, can be subdivided into six discrete typing units (DTUs), TcI, TcIIa, TcIIb, TcIIc, TcIId or TcIIe, each having distinct epidemiologically important features.
Ma, Jonathan, Llewellyn, Martin S, Yeo, Matthew, Miles, Michael A, Lewis, M.D., Miles, M.A., Lewis, Michael D, Carrasco, Hernán J, Ma, J., Yeo, M., Carrasco, H.J., Llewellyn, M.S.   +11 more
core   +1 more source

Extraordinary Trypanosoma cruzi diversity within single mammalian reservoir hosts implies a mechanism of diversifying selection. [PDF]

, 2011
Trypanosoma cruzi is an evolutionarily ancient parasitic protozoan endemic to the Americas. Multiple genetic and phenotypic markers indicate that this parasite is highly diverse, with several divergent and discrete major genotypes reported.
Rivett-Carnac, John B, John B. Rivett-Carnac, Michael A. Miles, Lewis, Michael D., Martin S. Llewellyn, Fitzpatrick, Sinead, Matthew Yeo, Michael D. Lewis, Llewellyn, Martin S, Yeo, Matthew, Rivett-Carnac, John B., Miles, Michael A, Lewis, Michael D, Michael W. Gaunt, Gaunt, Michael W., Miles, Michael A., Gaunt, Michael W, Sinead Fitzpatrick, Llewellyn, Martin S.   +18 more
core   +1 more source

Eco-epidemiological study of an endemic Chagas disease region in northern Colombia reveals the importance of Triatoma maculata (Hemiptera: Reduviidae), dogs and Didelphis marsupialis in Trypanosoma cruzi maintenance

Parasites & Vectors, 2015
Background In Colombia, Rhodnius prolixus and Triatoma dimidiata are the main domestic triatomine species known to transmit T. cruzi. However, there are multiple reports of T. cruzi transmission involving secondary vectors.
Omar Cantillo-Barraza, Edilson Garcés, Andrés Gómez-Palacio, Luis A. Cortés, André Pereira, Paula L. Marcet, Ana M. Jansen, Omar Triana-Chávez   +7 more
doaj   +1 more source

Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics

Biology, 2023
Chagas disease, caused by Trypanosoma cruzi and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines.
Edem Fiatsonu, Aniruddha Deka, Martial L. Ndeffo-Mbah   +2 more
doaj   +1 more source

The genetic diversity of trypanosoma cruzi, multiclonality of natural populations and the characterisation of Paraguayan isolates and experimentally derived T. cruzi I. hydrids [PDF]

The aims of this PhD programme were: optimisation of conditions for clonal isolation of Trypanosoma cruzi from individual triatomine bugs and molecular characterisation of clonal isolates from field sites in Paraguay, with special consideration given
Yeo, Matthew
core   +1 more source

Broad patterns in domestic vector-borne Trypanosoma cruzi transmission dynamics: synanthropic animals and vector control

Parasites & Vectors, 2015
Background Chagas disease (caused by Trypanosoma cruzi) is the most important neglected tropical disease (NTD) in Latin America, infecting an estimated 5.7 million people in the 21 countries where it is endemic. It is one of the NTDs targeted for control
Jennifer K. Peterson, Sarah M. Bartsch, Bruce Y. Lee, Andrew P. Dobson   +3 more
doaj   +1 more source