Results 21 to 30 of about 10,211,329 (187)

Detection of Trypanosoma cruzi and Trypanosoma rangeli infection in triatomine vectors by amplification of the histone H2A/SIRE and the sno-RNA-C11 genes Detecção da infecção por Trypanosoma cruzi e Trypanosoma rangeli em vetores triatomíneos através da amplificação dos gens de histona H2A/SIRE e sno-RNA-C11

Revista do Instituto de Medicina Tropical de São Paulo, 2007
Trypanosoma rangeli is non pathogenic for humans but of important medical and epidemiological interest because it shares vertebrate hosts, insect vectors, reservoirs and geographic areas with T. cruzi, the etiological agent of Chagas disease.
Paula Ximena Pavia, Gustavo Adolfo Vallejo, Marleny Montilla, Rubén Santiago Nicholls, Concepción Judith Puerta   +4 more
doaj   +1 more source

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

Parasites & Vectors, 2022
Background Components of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases (SODs) constitute key components of antioxidant defense systems, removing excess superoxide anions by ...
Jéssica Hickson, Lucas Felipe Almeida Athayde, Thainá Godinho Miranda, Policarpo Ademar Sales Junior, Anderson Coqueiro dos Santos, Lúcia Maria da Cunha Galvão, Antônia Cláudia Jácome da Câmara, Daniella Castanheira Bartholomeu, Rita de Cássia Moreira de Souza, Silvane Maria Fonseca Murta, Laila Alves Nahum   +10 more
doaj   +1 more source

Xanthine Analogs Suppress Trypanosoma cruzi Infection In Vitro Using PDEs as Targets

Microbiology Research, 2022
Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, has infected 6 million people, putting 70 million people at risk worldwide. Presently, very limited drugs are available, and these have severe side effects.
Amita R. Banga, Konjeti R. Sekhar, Kayla J. Rayford, Ashutosh Arun, Peace Odiase, Amar P. Garg, Maria F. Lima, Pius N. Nde, Fernando Villalta, Girish Rachakonda   +9 more
doaj   +1 more source

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

PLoS Pathogens, 2009
Host defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to several microorganisms, such as ...
Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda   +11 more
doaj   +1 more source

Immunocytochemical identification of leishmania and Trypanosoma cruzi amastigotes in situ with homologous and heterologous polyclonal antibodies

Revista da Sociedade Brasileira de Medicina Tropical, 1991
The unlabelled antibody peroxidase-antiperoxidase method was used to study the immunocytochemical properties of Leishmania and Trypanosoma cruzi amastigotes in situ after tissues had been submitted to different fixation procedures. Antisera were obtained
A.J.A. Barbosa, C.A. da Costa, M.S.M. Michalick, W. Mayrink, R.T. Gazzinelli, W.L. Tafuri   +5 more
doaj   +3 more sources

Genome size, karyotype polymorphism and chromosomal evolution in Trypanosoma cruzi. [PDF]

PLoS ONE, 2011
BackgroundThe Trypanosoma cruzi genome was sequenced from a hybrid strain (CL Brener). However, high allelic variation and the repetitive nature of the genome have prevented the complete linear sequence of chromosomes being determined.
Renata T Souza, Fábio M Lima, Roberto Moraes Barros, Danielle R Cortez, Michele F Santos, Esteban M Cordero, Jeronimo Conceiçao Ruiz, Samuel Goldenberg, Marta M G Teixeira, José Franco da Silveira   +9 more
doaj   +1 more source

Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi

mSphere, 2023
The flagellated kinetoplastid protozoan and causative agent of human Chagas disease, Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its complex life cycle. In these disparate environments, T.
Madalyn M. Won, Aaron Baublis, Barbara A. Burleigh   +2 more
doaj   +1 more source

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection. [PDF]

PLoS Pathogens, 2016
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite, Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global insights into the T.
Yuan Li, Sheena Shah-Simpson, Kwame Okrah, A Trey Belew, Jungmin Choi, Kacey L Caradonna, Prasad Padmanabhan, David M Ndegwa, M Ramzi Temanni, Héctor Corrada Bravo, Najib M El-Sayed, Barbara A Burleigh   +11 more
doaj   +1 more source

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal. [PDF]

, 2015
An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes.
Bustamante, Marinely, Torrico, Faustino, Michael A. Miles, Messenger, L.A., Torrico, F., Marycruz Torrico, Huaranca, Carlos, Huaranca, C., Torrico, Marycruz, Marinely Bustamante, Carlos Huaranca, Garcia, Lineth, Bustamante, M., Louisa A. Messenger, Miles, Michael A., Lineth Garcia, Miles, Michael, Miles, M.A., Mathieu Vanhove, Messenger, Louisa A, Garcia, L., Martin S. Llewellyn, Llewellyn, Martin S, Vanhove, Mathieu, Vanhove, M., Messenger, Louisa A., Miles, Michael A, Faustino Torrico, Llewellyn, Martin, Llewellyn, Martin S., Messenger, Louisa, Llewellyn, M.S., Torrico, M.   +32 more
core   +1 more source

Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

Journal of Neuroinflammation, 2017
Background In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T.
Andrea Alice Silva, Rafael Rodrigues Silva, Daniel Gibaldi, Rafael Meyer Mariante, Jessica Brandão dos Santos, Isabela Resende Pereira, Otacílio Cruz Moreira, Joseli Lannes-Vieira   +7 more
doaj   +1 more source