Results 1 to 10 of about 10,211,329 (187)

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production [PDF]

PLoS Neglected Tropical Diseases, 2013
Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent of Chagas disease, a chronic infectious illness that affects millions of people worldwide. Although the role of TLR and Nod1 in the control of T.
Ana Claudia Torrecilhas, Karina Ramalho Bortoluci, Jm Alvarez   +2 more
exaly   +2 more sources

Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice [PDF]

Brain, Behavior, & Immunity - Health
Chagas’ disease is a life-threatening condition caused by Trypanosoma cruzi. Patients with chronic disease may develop gastrointestinal, neurological, or associated neuro-digestive dysfunctions. CNS invasion by T.
Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri, Jr.   +11 more
doaj   +2 more sources

Analyses of 32 Loci Clarify Phylogenetic Relationships among Trypanosoma cruzi Lineages and Support a Single Hybridization prior to Human Contact [PDF]

PLoS Neglected Tropical Diseases, 2011
The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T. cruzi I and II, corresponding to discrete typing units TcI and TcII-VI under a recently proposed nomenclature. The
Carlos Machado, Carlos Flores-López
exaly   +2 more sources

Repertoire, Genealogy and Genomic Organization of Cruzipain and Homologous Genes in Trypanosoma cruzi, T. cruzi-Like and Other Trypanosome Species [PDF]

PLoS ONE, 2012
Trypanosoma cruzi, the agent of Chagas disease, is a complex of genetically diverse isolates highly phylogenetically related to T. cruzi-like species, Trypanosoma cruzi marinkellei and Trypanosoma dionisii, all sharing morphology of blood and culture ...
João Alves, Silvia Celina Alfieri, Luciana Lima   +2 more
exaly   +2 more sources

Assessment of the Performance of Indirect Immunofluorescence Assay for Chagas Disease in Dogs Using a Reference Panel of Four Chimeric Proteins. [PDF]

Vet Med Sci
We evaluated the performance of an indirect immunofluorescence (IIF) assay for detecting anti‐Trypanosoma cruzi IgG in dogs using four chimeric IBMP antigens and latent class analysis. The IIF assay showed suboptimal sensitivity and overall accuracy compared to ELISA and LCA‐based methods.
Silva ÂAO, Costa TF, Fontes ND, Santos EF, Rocha AVVO, Miranda LM, Almeida-Souza F, Costa FB, Nogueira RMS, Sampaio DD, Celedon PAF, Zanchin NIT, Costa APD, Santos FLN.   +13 more
europepmc   +2 more sources

New insights into Trypanosoma cruzi genetic diversity, and its influence on parasite biology and clinical outcomes

Frontiers in Immunology
Chagas disease, caused by Trypanosoma cruzi, remains a serious public health problem worldwide. The parasite was subdivided into six distinct genetic groups, called “discrete typing units” (DTUs), from TcI to TcVI. Several studies have indicated that the
Glaucia Alessio, Olindo Assis Martins-Filho, Marcio Sobreira Silva Araujo   +2 more
exaly   +3 more sources

Different Transcriptomic Responses After Moderate and Severe Heat Shock in Trypanosoma cruzi Epimastigotes. [PDF]

J Eukaryot Microbiol
ABSTRACT Trypanosoma cruzi undergoes heat stress during its life cycle. In this study, we performed a transcriptomic analysis of the heat shock response in epimastigotes from different T. cruzi strains. In both clone CL Brener and the Y strain, very few to no statistically significant variations were observed in the transcriptome at 37°C, whereas ...
Bottaro T, Penha LL, Silva R, Ürményi TP.   +3 more
europepmc   +2 more sources

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2006
Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas, Luiz Augusto-Pinto, Juliana R Pimenta, Luciana Bastos-Rodrigues, Vanessa F Gonçalves, Santuza M R Teixeira, Egler Chiari, Angela C V Junqueira, Octavio Fernandes, Andréa M Macedo, Carlos Renato Machado, Sérgio D J Pena   +11 more
doaj   +2 more sources

Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]

PeerJ, 2020
Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto, Gabriel Díaz-Campusano, Nicol Quiroga, Catalina Muñoz-San Martín, Ninette Rives-Blanchard, Fernando Torres-Pérez   +5 more
doaj   +2 more sources

Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. [PDF]

PLoS ONE, 2013
Little is known on the role played by Neotropical wild carnivores in the Trypanosoma cruzi transmission cycles. We investigated T. cruzi infection in wild carnivores from three sites in Brazil through parasitological and serological tests.
Fabiana Lopes Rocha, André Luiz Rodrigues Roque, Juliane Saab de Lima, Carolina Carvalho Cheida, Frederico Gemesio Lemos, Fernanda Cavalcanti de Azevedo, Ricardo Corassa Arrais, Daniele Bilac, Heitor Miraglia Herrera, Guilherme Mourão, Ana Maria Jansen   +10 more
doaj   +1 more source