Results 1 to 10 of about 42,346 (181)

Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice [PDF]

Brain, Behavior, & Immunity - Health
Chagas’ disease is a life-threatening condition caused by Trypanosoma cruzi. Patients with chronic disease may develop gastrointestinal, neurological, or associated neuro-digestive dysfunctions. CNS invasion by T.
Sergio M. Borghi, Aparecida D. Malvezi, Maria Isabel Lovo-Martins, Victor Fattori, Tiago H. Zaninelli, Mariana M. Bertozzi, Camila R. Ferraz, Thiago M. Cunha, Rubia Casagrande, Marli C. Martins-Pinge, Phileno Pinge-Filho, Waldiceu A. Verri, Jr.   +11 more
doaj   +2 more sources

Analyses of 32 Loci Clarify Phylogenetic Relationships among Trypanosoma cruzi Lineages and Support a Single Hybridization prior to Human Contact [PDF]

PLoS Neglected Tropical Diseases, 2011
The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T. cruzi I and II, corresponding to discrete typing units TcI and TcII-VI under a recently proposed nomenclature. The
CARLOS A Flores-López, CARLOS A Machado
exaly   +2 more sources

Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]

PLoS Pathogens, 2006
Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas, Luiz Augusto-Pinto, Juliana R Pimenta, Luciana Bastos-Rodrigues, Vanessa F Gonçalves, Santuza M R Teixeira, Egler Chiari, Angela C V Junqueira, Octavio Fernandes, Andréa M Macedo, Carlos Renato Machado, Sérgio D J Pena   +11 more
doaj   +2 more sources

Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]

PeerJ, 2020
Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto, Gabriel Díaz-Campusano, Nicol Quiroga, Catalina Muñoz-San Martín, Ninette Rives-Blanchard, Fernando Torres-Pérez   +5 more
doaj   +2 more sources

Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. [PDF]

PLoS ONE, 2013
Little is known on the role played by Neotropical wild carnivores in the Trypanosoma cruzi transmission cycles. We investigated T. cruzi infection in wild carnivores from three sites in Brazil through parasitological and serological tests.
Fabiana Lopes Rocha, André Luiz Rodrigues Roque, Juliane Saab de Lima, Carolina Carvalho Cheida, Frederico Gemesio Lemos, Fernanda Cavalcanti de Azevedo, Ricardo Corassa Arrais, Daniele Bilac, Heitor Miraglia Herrera, Guilherme Mourão, Ana Maria Jansen   +10 more
doaj   +1 more source

Trypanosoma cruzi: ancestral genomes and population structure

Memorias do Instituto Oswaldo Cruz, 2009
Although the genome of Trypanosoma cruzi has been completely sequenced, little is known about its population structure and evolution. Since 1999, two major evolutionary lineages presenting distinct epidemiological characteristics have been recognised: T.
Sérgio DJ Pena, Carlos Renato Machado, Andréa Mara Macedo   +2 more
doaj   +1 more source

Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term
María G Alvarez, Graciela L Bertocchi, Gretchen Cooley, María C Albareda, Rodolfo Viotti, Damián E Perez-Mazliah, Bruno Lococo, Melisa Castro Eiro, Susana A Laucella, Rick L Tarleton   +9 more
doaj   +1 more source

Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. [PDF]

, 2012
BACKGROUND: Trypanosoma cruzi marinkellei is a bat-associated parasite of the subgenus Schizotrypanum and it is regarded as a T. cruzi subspecies. Here we report a draft genome sequence of T. c. marinkellei and comparison with T. c. cruzi.
Andersson, B., Cornelis J Marinkelle, Kevin M Tyler, Butler, Claire E, Messenger, L.A., Talavera-López, Carlos, Björn Andersson, Louisa A Messenger, Claire E Butler, Michael A Miles, Ochaya, S., Marinkelle, Cornelis J, Butler, Claire, Talavera-López, C., Carlos Talavera-López, Miles, M.A., Michael D Lewis, Ochaya, Stephen, Messenger, Louisa A, Butler, C.E., Stephen Ochaya, Franzén, Oscar, Oscar Franzén, Llewellyn, Martin S, Martin S Llewellyn, Tyler, K.M., Miles, Michael A, Lewis, M.D., Lewis, Michael D, Andersson, Björn, Franzén, O., Tyler, Kevin, Tyler, Kevin M, Llewellyn, M.S., Marinkelle, C.J.   +34 more
core   +1 more source

Genomic comparison of Trypanosoma conorhini and Trypanosoma rangeli to Trypanosoma cruzi strains of high and low virulence

BMC Genomics, 2018
Background Trypanosoma conorhini and Trypanosoma rangeli, like Trypanosoma cruzi, are kinetoplastid protist parasites of mammals displaying divergent hosts, geographic ranges and lifestyles. Largely nonpathogenic T. rangeli and T.
Katie R Bradwell, Vishal N Koparde, Andrey V Matveyev, Myrna G Serrano, João M P Alves, Hardik Parikh, Bernice Huang, Vladimir Lee, Oneida Espinosa-Alvarez, Paola A Ortiz, André G Costa-Martins, Marta M G Teixeira, Gregory A Buck   +12 more
doaj   +1 more source

Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults.

PLoS Neglected Tropical Diseases, 2013
BackgroundAdults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells.
María C Albareda, Ana M De Rissio, Gonzalo Tomas, Alicia Serjan, María G Alvarez, Rodolfo Viotti, Laura E Fichera, Mónica I Esteva, Daniel Potente, Alejandro Armenti, Rick L Tarleton, Susana A Laucella   +11 more
doaj   +1 more source