Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults. [PDF]
PLoS Neglected Tropical Diseases, 2013 BackgroundAdults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells.
María C Albareda +11 more
doaj +43 more sources
Cytotaxonomy of Trypanosoma cruzi (Chagas, 1909): Differentiation of T. cruzi I (TcI) and T. cruzi II (TcII) Genotypes Using Cytogenetic Markers. [PDF]
Am J Trop Med Hyg, 2019 Chagas disease is a public health problem caused by the Trypanosoma cruzi, and the T. cruzi I (TcI) and T. cruzi II (TcII) groups are considered important genotypes from the clinical point of view. Currently, the groups need to be molecularly analyzed for their identification; thus, we cytogenetically analyzed these groups with the objective of ...
Oliveira ABB +6 more
europepmc +5 more sources
Protective role of TRPV1+ nociceptive neurons communication to macrophages against T. cruzi infection in mice [PDF]
Brain, Behavior, & Immunity - HealthChagas’ disease is a life-threatening condition caused by Trypanosoma cruzi. Patients with chronic disease may develop gastrointestinal, neurological, or associated neuro-digestive dysfunctions. CNS invasion by T.
Sergio M. Borghi +11 more
doaj +2 more sources
Astrocyte Apoptosis and HIV Replication Are Modulated in Host Cells Coinfected with Trypanosoma cruzi [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The protozoan Trypanosoma cruzi is the etiological agent of Chagas disease. In immunosuppressed individuals, as it occurs in the coinfection with human immunodeficiency virus (HIV), the central nervous system may be affected. In this regard, reactivation
Javier M. Urquiza +11 more
doaj +3 more sources
Editorial: Unravelling T. cruzi Biology. [PDF]
Front Cell Infect Microbiol, 2020 Taylor MC, Lander N, Yoshida N.
europepmc +5 more sources
Cardiomyocyte oxidants production may signal to T. cruzi intracellular development. [PDF]
PLoS Negl Trop Dis, 2017 Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a variable clinical course, varying from asymptomatic to serious debilitating pathologies with cardiac, digestive or cardio-digestive impairment. Previous studies using two clonal T. cruzi populations, Col1.7G2 (T. cruzi I) and JG (T.
Dias PP +7 more
europepmc +5 more sources
Assessing anti-T. cruzi candidates in vitro for sterile cidality. [PDF]
Int J Parasitol Drugs Drug Resist, 2016 Total clearance of the T. cruzi infection - referred to herein as "sterile cure" - seems to be a critical prerequisite for new drug candidates for Chagas disease, ensuring long-term beneficial effects for patients in the chronic indeterminate stage. This requirement is notably supported by the recent findings of clinical studies involving posaconazole ...
Cal M +4 more
europepmc +5 more sources
Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]
PLoS Pathogens, 2006 Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas +11 more
doaj +2 more sources
Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]
PeerJ, 2020 Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto +5 more
doaj +2 more sources
Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. [PDF]
PLoS ONE, 2013 Little is known on the role played by Neotropical wild carnivores in the Trypanosoma cruzi transmission cycles. We investigated T. cruzi infection in wild carnivores from three sites in Brazil through parasitological and serological tests.
Fabiana Lopes Rocha +10 more
doaj +1 more source