NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent of Chagas disease, a chronic infectious illness that affects millions of people worldwide. Although the role of TLR and Nod1 in the control of T.
Ana Claudia Torrecilhas +2 more
exaly +2 more sources
Trypanosoma cruzi infection in neotropical wild carnivores (Mammalia: Carnivora): at the top of the T. cruzi transmission chain. [PDF]
PLoS ONE, 2013 Little is known on the role played by Neotropical wild carnivores in the Trypanosoma cruzi transmission cycles. We investigated T. cruzi infection in wild carnivores from three sites in Brazil through parasitological and serological tests.
Fabiana Lopes Rocha +10 more
doaj +4 more sources
Analyses of 32 Loci Clarify Phylogenetic Relationships among Trypanosoma cruzi Lineages and Support a Single Hybridization prior to Human Contact [PDF]
PLoS Neglected Tropical Diseases, 2011 The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T. cruzi I and II, corresponding to discrete typing units TcI and TcII-VI under a recently proposed nomenclature. The
CARLOS Machado, CARLOS Flores-López
exaly +2 more sources
Frontiers in ImmunologyChagas disease, caused by Trypanosoma cruzi, remains a serious public health problem worldwide. The parasite was subdivided into six distinct genetic groups, called “discrete typing units” (DTUs), from TcI to TcVI. Several studies have indicated that the
Glaucia Alessio +2 more
exaly +3 more sources
Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. [PDF]
PLoS Pathogens, 2006 Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Salpha RNA genes, and sequence ...
Jorge M de Freitas +11 more
doaj +2 more sources
Trypanosoma cruzi-infected triatomines and rodents co-occur in a coastal island of northern Chile [PDF]
PeerJ, 2020 Trypanosoma cruzi, the cause agent of Chagas disease, is transmitted mainly by blood-feeding insects of the subfamily Triatominae. The T. cruzi life cycle alternates between triatomines and mammalian hosts, excluding birds and reptiles.
Ricardo Campos-Soto +5 more
doaj +2 more sources
Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term
María G Alvarez +9 more
doaj +1 more source
CD8+ T cells in Trypanosoma cruzi infection [PDF]
Current Opinion in Immunology, 2009 CD8(+) T cells have emerged as crucial players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent identification of the dominant targets of T. cruzi-specific T cells has allowed investigators to follow the generation of and document the functionality of T cell responses in both ...
Angel M, Padilla +2 more
openaire +2 more sources
Trypanosoma cruzi: ancestral genomes and population structure
Memorias do Instituto Oswaldo Cruz, 2009 Although the genome of Trypanosoma cruzi has been completely sequenced, little is known about its population structure and evolution. Since 1999, two major evolutionary lineages presenting distinct epidemiological characteristics have been recognised: T.
Sérgio DJ Pena +2 more
doaj +1 more source
The promise of T. cruzi genomics [PDF]
Nature, 2010 The publishing of the first Trypanosoma cruzi genome sequence was hailed as “a huge intellectual triumph”, but what has it delivered?
openaire +2 more sources