Results 11 to 20 of about 42,346 (181)

NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production. [PDF]

PLoS Neglected Tropical Diseases, 2013
Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent of Chagas disease, a chronic infectious illness that affects millions of people worldwide. Although the role of TLR and Nod1 in the control of T.
Virginia M Gonçalves, Kely C Matteucci, Carina L Buzzo, Bruna H Miollo, Danny Ferrante, Ana C Torrecilhas, Mauricio M Rodrigues, Jose M Alvarez, Karina R Bortoluci   +8 more
doaj   +1 more source

Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi

Frontiers in Immunology, 2018
Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts.
Fabricio Montalvão, Fabricio Montalvão, Danielle Oliveira Nascimento, Marise P. Nunes, Carolina M. Koeller, Alexandre Morrot, Alexandre Morrot, Leticia Miranda S. Lery, Paulo M. Bisch, Santuza M. R. Teixeira, Rita Vasconcellos, Leonardo Freire-de-Lima, Marcela F. Lopes, Norton Heise, George A. DosReis, Célio Geraldo Freire-de-Lima   +15 more
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Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. [PDF]

, 2011
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable
Michael A. Miles, Acosta , N,, Llewellyn Martin S., Nidia Acosta, Louisa A Messenger, Acosta Nidia, Bhattacharyya Tapan, Carrasco, Hernan J, Yeo, Matthew, Hernan J Carrasco, Bhattacharyya , T,, Miles, Michael A., Llewellyn , MS,, Isabel L. Mauricio, Yeo Matthew, Miles, M.A., Michael D Lewis, Messenger, Louisa A, Yeo, M., Acosta, N., Mauricio, Isabel Larguinho, Matthew Yeo, Patricio Diosque, Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Lewis, M.D., Messenger Louisa A., Diosque, P., Lewis, Michael D, Miles , MA., Carrasco Hernan J., Llewellyn, Martin S., Llewellyn, M.S., Lewis Michael D., Messenger, L.A., Acosta, Nidia, Lewis, Michael D., Carrasco, H.J., Mauricio, I.L., Mauricio, Isabel L., Messenger, Loisa A., Lewis , MD,, Yeo , M,, Michael A Miles, Miles Michael A., Bhattacharyya, Tapan, Louisa A. Messenger, Carrasco , HJ,, Messenger , LA,, Isabel L Mauricio, Bhattacharyya, T., Diosque Patricio, Hernan J. Carrasco, Martin S. Llewellyn, Diosque, Patricio, Michael D. Lewis, Mauricio, Isabel L, Mauricio Isabel L., Diosque , P,, Tapan Bhattacharyya, Carrasco, Hernán J.   +61 more
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Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing. [PDF]

, 2012
BACKGROUND: Mitochondrial DNA is a valuable taxonomic marker due to its relatively fast rate of evolution. In Trypanosoma cruzi, the causative agent of Chagas disease, the mitochondrial genome has a unique structural organization consisting of 20-50 ...
Andersson, B., Andersson, B,, Carrasco, H., Miles, M., Llewellyn Martin S., Louisa A Messenger, Messenger, LA, Bhattacharyya Tapan, Franzen, O, Carrasco, Hernan J, Andersson Björn, Messenger, L., Hernan J Carrasco, Hernan J. Carrasco (5649058), Martin S. Llewellyn (155605), Miles, M.A., Michael D Lewis, Messenger, Louisa A, Louisa A. Messenger (172069), Llewellyn, M., Oscar Franzén, Michael A. Miles (43726), Llewellyn, Martin S, Ramírez, J.D., Martin S Llewellyn, Bhattacharyya, T, Miles, MA, Miles, Michael A, Lewis, M.D., Messenger Louisa A., Tapan Bhattacharyya (172083), Lewis, Michael D, Carrasco Hernan J., Llewellyn, M.S., Lewis Michael D., Ramírez Juan David, Messenger, L.A., Björn Andersson, Juan David Ramírez, Carrasco, H.J., Andresson, B., Michael D. Lewis (172100), Michael A Miles, Miles Michael A., Bhattacharyya, Tapan, Ramirez, J.-D., Franzén Oscar, David, Ramirez J, Juan David Ramírez (172106), Ramírez, Juan David, Lewis, M., Björn Andersson (2663065), Carrasco, HJ, Bhattacharyya, T., Traub-Csekö, Y.M., Franzén, Oscar, Oscar Franzén (172092), Llewellyn, MS, Lewis, MD, Andersson, Björn, Franzén, O., Tapan Bhattacharyya   +61 more
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Xanthine Analogs Suppress Trypanosoma cruzi Infection In Vitro Using PDEs as Targets

Microbiology Research, 2022
Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, has infected 6 million people, putting 70 million people at risk worldwide. Presently, very limited drugs are available, and these have severe side effects.
Amita R. Banga, Konjeti R. Sekhar, Kayla J. Rayford, Ashutosh Arun, Peace Odiase, Amar P. Garg, Maria F. Lima, Pius N. Nde, Fernando Villalta, Girish Rachakonda   +9 more
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Detection of Trypanosoma cruzi and Trypanosoma rangeli infection in triatomine vectors by amplification of the histone H2A/SIRE and the sno-RNA-C11 genes Detecção da infecção por Trypanosoma cruzi e Trypanosoma rangeli em vetores triatomíneos através da amplificação dos gens de histona H2A/SIRE e sno-RNA-C11

Revista do Instituto de Medicina Tropical de São Paulo, 2007
Trypanosoma rangeli is non pathogenic for humans but of important medical and epidemiological interest because it shares vertebrate hosts, insect vectors, reservoirs and geographic areas with T. cruzi, the etiological agent of Chagas disease.
Paula Ximena Pavia, Gustavo Adolfo Vallejo, Marleny Montilla, Rubén Santiago Nicholls, Concepción Judith Puerta   +4 more
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Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

Parasites & Vectors, 2022
Background Components of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases (SODs) constitute key components of antioxidant defense systems, removing excess superoxide anions by ...
Jéssica Hickson, Lucas Felipe Almeida Athayde, Thainá Godinho Miranda, Policarpo Ademar Sales Junior, Anderson Coqueiro dos Santos, Lúcia Maria da Cunha Galvão, Antônia Cláudia Jácome da Câmara, Daniella Castanheira Bartholomeu, Rita de Cássia Moreira de Souza, Silvane Maria Fonseca Murta, Laila Alves Nahum   +10 more
doaj   +1 more source

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.

PLoS Pathogens, 2009
Host defense against the intracellular protozoan parasite Trypanosoma cruzi depends on Toll-like receptor (TLR)-dependent innate immune responses. Recent studies also suggest the presence of TLR-independent responses to several microorganisms, such as ...
Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda   +11 more
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Immunocytochemical identification of leishmania and Trypanosoma cruzi amastigotes in situ with homologous and heterologous polyclonal antibodies

Revista da Sociedade Brasileira de Medicina Tropical, 1991
The unlabelled antibody peroxidase-antiperoxidase method was used to study the immunocytochemical properties of Leishmania and Trypanosoma cruzi amastigotes in situ after tissues had been submitted to different fixation procedures. Antisera were obtained
A.J.A. Barbosa, C.A. da Costa, M.S.M. Michalick, W. Mayrink, R.T. Gazzinelli, W.L. Tafuri   +5 more
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Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection. [PDF]

PLoS Pathogens, 2016
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite, Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global insights into the T.
Yuan Li, Sheena Shah-Simpson, Kwame Okrah, A Trey Belew, Jungmin Choi, Kacey L Caradonna, Prasad Padmanabhan, David M Ndegwa, M Ramzi Temanni, Héctor Corrada Bravo, Najib M El-Sayed, Barbara A Burleigh   +11 more
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