Results 51 to 60 of about 154,948 (311)
Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
TNF-α (−308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
Diabetes, Metabolic Syndrome and Obesity, 2019 Birhanu Ayelign,1 Meaza Genetu,1 Tadelo Wondmagegn,1 Gashaw Adane,1 Markos Negash,1 Nega Berhane2 1Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Science, University of Gondar ...
Ayelign B +5 more
doaj
Medical Journal of Babylon, 2023 Background: Diabetes mellitus is a well-known chronic, metabolic disease characterized by elevated levels of blood glucose (BG) due to obsolete or relative insulin deficiency among other pathophysiological defects.
Ali Mousa Essa Albadri, Jawad K Al-Diwan
doaj +1 more source
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
Polycystic Ovary Syndrome (PCOS): Insights into Etiology, Genetic, Diagnosis, Treatment, and Future Directions. (A Comprehensive Review) [PDF]
مجلة التربية والعلمIn this paper, we obtained the nuclear energy levels for 48Cr isotope that resided in the pf -shell of shell model calculations. For nucleons that were outside closed and no core, they were calculated using skyrme interactions. The Skyrme (SLY5) was used
Lujain Ghannawi +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley +1 more source
, 2021 Study conducted in the region of Tumbes, in the north of Peru to assess the diagnostic accuracy of different risk scores and T2DM.
Antonio Bernabe-Ortiz (4099528)
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source