Results 41 to 50 of about 154,948 (311)
PLOS ONE, 2022 The cognitive impairment, depression, a decrease in the ability to perform activities of daily living (ADLs), and salivary gland dysfunction, as indicated by the reduction of alpha-amylase activity, have been reported in patients with type 2 diabetes (T2DM).
Savitree Thummasorn +8 more
openaire +3 more sources
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Improving T2DM Outcomes in Primary Care [PDF]
, 2022 Background: In the United States (US), over 34 million Americans have diabetes mellitus and 90% -95% of these individuals have Type 2 diabetes mellitus (T2DM) (Centers for Disease Control and Prevention [CDC], 2021).
Francisco, Isabel
core +2 more sources
Molecular Pathways Regulating Circadian Rhythm and Associated Diseases
Frontiers in Bioscience-LandmarkCircadian rhythms, the natural cycles of physical, mental, and behavioral changes that follow a roughly 24-hour cycle, are known to have a profound effect on the human body.
Min Ding +3 more
doaj +1 more source
Advanced Science, EarlyView.CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen +19 more
wiley +1 more source
Advanced Science, EarlyView.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
Фармакоэкономика, 2017 To date, several options for starting and intensifying insulin therapy in patients with type 2 diabetes mellitus (T2DM) have been proposed. Meta-analyzes of the recent results shows that, with adequate use, all these regimens have the similar efficacy ...
E. V. Biryukova, V. I. Ignat’eva
doaj +1 more source
Diet, Physical Activity, and Their Impact on Chronic Diseases (Hypertension and T2DM) among North-Eastern Morocco’s Population [PDF]
Morocco is a country in “nutritional transition”, with a traditional Mediterranean food model that is increasingly moving towards a Western model. To study this transition, we aimed to determine the prevalence of chronic diseases (hypertension and T2DM ...
Saliha MHARCHI, Abdellatif MAAMRI
core +2 more sources
Advanced Science, EarlyView.In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang +13 more
wiley +1 more source
Assessment of Endothelial Dysfunction in T2DM: A Doppler Ultrasound Study Correlated with CRP Levels, Glycemic Control, and BMI [PDF]
Background and Aim: Endothelial dysfunction is a crucial precursor to atherosclerosis and cardiovascular complications, particularly prevalent in individuals with type 2 diabetes mellitus (T2DM).
Karthikeyan Selvaraj +2 more
core +1 more source