Results 41 to 50 of about 137,868 (314)
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Medical Journal of Babylon, 2023 Background: Diabetes mellitus is a well-known chronic, metabolic disease characterized by elevated levels of blood glucose (BG) due to obsolete or relative insulin deficiency among other pathophysiological defects.
Ali Mousa Essa Albadri, Jawad K Al-Diwan
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao +5 more
wiley +1 more source
Фармакоэкономика, 2017 To date, several options for starting and intensifying insulin therapy in patients with type 2 diabetes mellitus (T2DM) have been proposed. Meta-analyzes of the recent results shows that, with adequate use, all these regimens have the similar efficacy ...
E. V. Biryukova, V. I. Ignat’eva
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi +6 more
wiley +1 more source
Diet, Physical Activity, and Their Impact on Chronic Diseases (Hypertension and T2DM) among North-Eastern Morocco’s Population [PDF]
Morocco is a country in “nutritional transition”, with a traditional Mediterranean food model that is increasingly moving towards a Western model. To study this transition, we aimed to determine the prevalence of chronic diseases (hypertension and T2DM ...
Saliha MHARCHI, Abdellatif MAAMRI
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola +14 more
wiley +1 more source
Assessment of Endothelial Dysfunction in T2DM: A Doppler Ultrasound Study Correlated with CRP Levels, Glycemic Control, and BMI [PDF]
Background and Aim: Endothelial dysfunction is a crucial precursor to atherosclerosis and cardiovascular complications, particularly prevalent in individuals with type 2 diabetes mellitus (T2DM).
Karthikeyan Selvaraj +2 more
core +1 more source
TNF-α (−308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients
Diabetes, Metabolic Syndrome and Obesity, 2019 Birhanu Ayelign,1 Meaza Genetu,1 Tadelo Wondmagegn,1 Gashaw Adane,1 Markos Negash,1 Nega Berhane2 1Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Science, University of Gondar ...
Ayelign B +5 more
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