Results 21 to 30 of about 154,948 (311)

T2DM/CKD genetic risk scores and the progression of diabetic kidney disease in T2DM subjects

Gene, 2023
Abstract This study explored the predictive value of genetic risk scores (GRS) for diabetic kidney disease (DKD) progression, Major Cardiovascular Events (MCVE), and All-Cause Mortality (ACM) in type 2 diabetes mellitus (T2DM) patients. We assessed 30 T2DM and CKD GWAS-derived single nucleotide polymorphisms (SNPs) in 400 Central European ...
David Galuška, Lukáš Pácal, Katarína Chalásová, Petra Divácká, Jitka Řehořová, Jan Svojanovský, Jaroslav A. Hubáček, Věra Lánská, Kateřina Kaňková   +8 more
openaire   +3 more sources

Reversal and Remission of T2DM – An Update for Practitioners

Vascular Health and Risk Management, 2022
Over the past 50 years, many countries around the world have faced an unchecked pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has done very little to check its growth, the pandemic of diabesity now threatens to make health-care systems economically more difficult for governments and individuals to manage within ...
Lina Shibib, Mo Al-Qaisi, Ahmed Ahmed, Alexander D Miras, David Nott, Marc Pelling, Stephen E Greenwald, Nicola Guess   +7 more
openaire   +4 more sources

Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients [PDF]

, 2017
There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic
Nasser M. Al-Daghri, Mohammed, A.K., Abdul Khader Mohammed, Hussain, S.D., Omar S. Al-Attas, Ansari, M.G.A, Kaiser Wani, Wani, K., Mohammed Ghouse Ahmed Ansari, Wani, K, Alokail, M.S., Mohammed, A.K, Hussain, S.D, Tripathi, G, Majed S. Alokail, Tripathi, G., Al-Attas, O.S, Sabico, S, Gyanendra Tripathi, Sabico, S., Alokail, M.S, Al-Daghri, N.M, Syed D. Hussain, Shaun Sabico, Al-Attas, O.S., Ansari, M.G.A., Al-Daghri, N.M.   +26 more
core   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

SP prevents T2DM complications by immunomodulation [PDF]

Scientific Reports, 2020
AbstractType 2 diabetic mellitus (T2DM) is characterized by systemic inflammation and insulin resistance due to obesity, and this leads to critical complications, including retinopathy and nephropathy. This study explored the therapeutic effect of substance-p (SP), a neuropeptide, on T2DM progression and its complications. To examine whether SP affects
Baek, Sang-Min, Kim, Kiyoung, Kim, Suna, Son, Youngsook, Hong, Hyun Sook, Yu, Seung-Young   +5 more
openaire   +2 more sources

Vitamin D supplementation as an adjuvant therapy for patients with T2DM : an 18-month prospective interventional study [PDF]

, 2012
Background Vitamin D deficiency has been associated with impaired human insulin action, suggesting a role in the pathogenesis of diabetes mellitus type 2 (T2DM).
Al-Othman, Abdulaziz, Osama Moharram, Alokail Majed S, El-Kholie, Emad, Kumar Sudhesh, Sabico, Shaun, Sudhesh Kumar, Sabico Shaun, George P Chrousos, Al-Othman Abdulaziz, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Majed S Alokail, Al-Saleh Yousef, Yousef Al-Saleh, Alkharfy Khalid M, Chrousos, George P., Kumar, Sudhesh, Chrousos George P, Abdulaziz Al-Othman, Emad El-Kholie, Moharram Osama, Nasser M Al-Daghri, Shaun Sabico, El-Kholie Emad, Moharram, Osama, Al-Daghri Nasser M, Alkharfy, Khalid M., Khalid M Alkharfy   +29 more
core   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

DIABETES MELLITUS: THE MODERN STATE OF THE ISSUE (PART 1)

Паёми Сино, 2019
The authors analyzed numerous scientific studies on the problem of type 2 diabetes mellitus (T2DM), the extent of the spread is causing concern among experts around the world.
M.U. SHAROFOVA, SH.S. SAGDIEVA, S.D. YUSUFI   +2 more
doaj   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Effects of probiotics in patients with diabetes mellitus type 2 : study protocol for a randomized, double-blind, placebo-controlled trial [PDF]

, 2013
Background: Low grade chronic inflammation is observed in patients with type 2 diabetes mellitus (T2DM). Endotoxin derived from gut bacteria may act as a potent inflammatory stimulant.
Majed S Alokail, Sabico, S, Yousef Al-Saleh, Sabico, Shaun, McTernan, PG, Alokail, MS, Nasser M Al-Daghri, Vanhoutte, Paul M., Alokail, Majed S., Al-Daghri, NM, Shaun Sabico, Alkharfy, KM, Vanhoutte, PMGR, Philip G McTernan, Al-Saleh, Yousef, Al-Daghri, Nasser M., Al-Saleh, Y, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy, Paul M Vanhoutte   +20 more
core   +1 more source