Results 11 to 20 of about 154,948 (311)

T2DM: Why Epigenetics? [PDF]

Journal of Nutrition and Metabolism, 2011
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the ...
Fradin, Delphine, Bougneres, Pierre
core   +6 more sources

Effect of hydroxychloroquine on glycemic variability in type 2 diabetes patients uncontrolled on glimepiride and metformin therapy

Indian Journal of Endocrinology and Metabolism, 2022
Background and Aims: No study to date has assessed the effect of hydroxychloroquine on various parameters of glycaemic variability. To assess the effect of hydroxychloroquine on glycaemic variability in type 2 diabetes patients uncontrolled on ...
Rajesh Rajput, Suyasha Saini, Siddhant Rajput, Parankush Upadhyay   +3 more
doaj   +1 more source

Carriers of the TCF7L2 rs7903146, rs12255372 risk alleles in the south Tamil Nadu T2DM patients present with early incidence and insulin dependence

Indian Journal of Endocrinology and Metabolism, 2019
Background and Aims: Metabolic abnormalities in T2DM (Type 2 diabetes mellitus) include classic manifestations such as impaired insulin secretion, synthesis and peripheral insulin resistance.
Kumaravel Velayutham, Balaji Ramanathan, Jeyasudha Murugan, Arulvani Murugan, Vishali Thavamani, Rohini Gomathinayagam   +5 more
doaj   +1 more source

Consequences of diabetes and pre-diabetes and the role of biochemical parameters of carbohydrate metabolism for the functioning of the prefrontal cortex in obese patients

Frontiers in Bioscience-Landmark, 2022
Background: The role of executive functions (EF) is to maintain particular behaviours in order to achieve intended goals. EF are crucial in management of pre-diabetes, diabetes and obesity which are grievous diseases and can lead to severe complications.
Natalia Lesiewska, Alina Borkowska, Roman Junik, Anna Kamińska, Katarzyna Jaracz, Maciej Bieliński   +5 more
doaj   +1 more source

Mitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole [PDF]

, 2011
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis.
Baharak Hooshiar Kashani, Antonella Cormio, TORRONI A., Pala M., MARRA M, Santoro Aurelia, Lancioni, Hovirag, ACHILLI A, Viola Grugni, Lancioni Hovirag, Grugni V., Cormio Antonella, Sirolla, Cristina, GRUGNI V, Anna Olivieri, Franceschi Claudio, Spazzafumo L., Cormio, Antonella, Testa Roberto, SIROLLA C, Torroni, Antonio, Ugo A. Perego, Hooshiar Kashani, Baharak, PEREGO UA, Boemi, Massimo, Grugni Viola, Olivieri Anna, Grugni, Viola, Hooshiar Kashani Baharak, Gadaleta Maria Nicola, Testa I., Bonfigli, Anna Rita, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Achilli A., Roberto Testa, Achilli A1, GANDINI F, TESTA I, Antonio Ceriello, Pala Maria, Gandini Francesca, TESTA R, Marra M., Spazzafumo, Liana, Testa R., Testa, Roberto, Semino Ornella, Marra, Maurizio, Carossa Valeria, Anna Rita Bonfigli, Cormio A, SPAZZAFUMO L, Maria Pala, Olivieri A., Ivano Testa, Olivieri, Anna, BOEMI M, Marra Maurizio, Perego, Ugo A., SANTORO A, SEMINO O, Achilli Alessandro, HOOSHIAR KASHANI B, Boemi M., Spazzafumo Liana, Battaglia V., Hooshiar Kashani B., Testa, Ivano, Aurelia Santoro, Torroni Antonio, Ceriello, Antonio, Boemi Massimo, Massimo Boemi, Valeria Carossa, Bonfigli A. R., LANCIONI H, Gandini, Francesca, Sirolla Cristina, Battaglia Vincenza, Gadaleta, Maria Nicola, BATTAGLIA V, Sirolla C., Santoro, Aurelia, Bonfigli Anna Rita, Gadaleta M. N., Ceriello A., Carossa, Valeria, CAROSSA V, Pala, Maria, FRANCESCHI C, Semino O., Ceriello Antonio, Ugo A Perego, Antonio Torroni, Maria Nicola Gadaleta, Testa Ivano, Perego U. A., BONFIGLI AR, Ornella Semino, Franceschi, Claudio, Maurizio Marra, Hovirag Lancioni, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, CERIELLO A, GADALETA MN, Francesca Gandini, PALA M, Carossa V., Cormio A., Lancioni H., OLIVIERI A, Perego Ugo A., Alessandro Achilli, Claudio Franceschi, Gandini F., Cristina Sirolla, Liana Spazzafumo   +119 more
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An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]

, 2012
Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Manju Sharma, Vikas Kumar, Danish Ahmed, Vikas Kumar, Pankaj S Yadav   +4 more
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Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation : a systematic review and economic evaluation [PDF]

, 2012
Background The prevalence of type 2 diabetes mellitus (T2DM) is increasing in the UK and worldwide. Before the onset of T2DM, there are two conditions characterised by blood glucose levels that are above normal but below the threshold for diabetes.
Black, C. (Corrinda), Snaith, Ailsa, Poobalan, A, Poobalan, A. S., A Snaith, Royle, P, G Scotland, Scotland, G., McNamee, P., Gillett, M, Poobalan, A., McNamee, P, Imamura, M., P Royle, N Waugh, Wyness, L., Jick, S, A Poobalan, Waugh, N, Imamura, M. (Mari), Snaith, A., A Brennan, Scotland, G, Snaith, A, S Jick, Brennan, A, M Boroujerdi, Brennan, Alan, Royle, P., Black, C, Gillett, M. (Michael), M Imamura, Black, C., Boroujerdi, M, Jick, S., Royle, Pamela, Waugh, N., Wyness, L, L Wyness, Boroujerdi, M., Imamura, M, Brennan, A., P McNamee, Wyness, Laura, McNamee, Paul, Gillett, M., C Black, Waugh, Norman, M Gillett, Scotland, Graham   +49 more
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Prevalence of Vitamin D Deficiency Between Type 2 Diabetes Mellitus Patients and Non-Diabetics in the Arab Gulf

Diabetes, Metabolic Syndrome and Obesity, 2022
Muhammed Hassan Nasr,1 Bassam Abdul Rasool Hassan,2 Noordin Othman,3 Mahmathi Karuppannan,4 Noorizan binti Abdulaziz,5 Ali Haider Mohammed,2,6 Mohammed Ahmed Alsarani,7 Mohammed Husain Eskembaji,7 Abdelmannan Mohamed Aman,8 Gamil Othman9 1Clinical ...
Nasr MH, Hassan BAR, Othman N, Karuppannan M, Abdulaziz N, Mohammed AH, Alsarani MA, Eskembaji MH, Aman AM, Othman G   +9 more
doaj  

Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2021
Amani MT Gusti,1,2 Safaa Y Qusti,1 Suhad M Bahijri,3,4 Eman A Toraih,5,6 Samia Bokhari,7 Sami M Attallah,8,9 Abdulwahab Alzahrani,10 Wafaa MA Alshehri,11 Hawazin Alotaibi,12 Manal S Fawzy13,14 1Department of Biochemistry, Faculty of Science, King ...
Gusti AMT, Qusti SY, Bahijri SM, Toraih EA, Bokhari S, Attallah SM, Alzahrani A, Alshehri WMA, Alotaibi H, Fawzy MS   +9 more
doaj  

A Versatile Model of Microfluidic Perifusion System for the Evaluation of C-Peptide Secretion Profiles: Comparison Between Human Pancreatic Islets and HLSC-Derived Islet-Like Structures

Biomedicines, 2020
A robust and easy-to-use tool for the ex vivo dynamic evaluation of pancreatic islet (PI) function is essential for further development of novel cell-based therapeutic approaches to treating diabetes.
Yonathan Gomez, Victor Navarro-Tableros, Ciro Tetta, Giovanni Camussi, Maria Felice Brizzi   +4 more
doaj   +1 more source