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T2DM: Why Epigenetics? [PDF]

Journal of Nutrition and Metabolism, 2011
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the ...
Fradin, Delphine, Bougneres, Pierre
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The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy [PDF]

Renal Failure, 2018
An association study was conducted to investigate the relation between 14 variants of glucose transporter 1 gene (SLC2A1) and the risk of type 2 diabetes (T2DM) leading to nephropathy. We also performed a meta-analysis of 11 studies investigating association between diabetic nephropathy (DN) and SLC2A1 variants. The cohort included 197 cases (T2DM with
Stefanidis, I., Tziastoudi, M.||, Tsironi, E. E., Dardiotis, Efthimios||, Tachmitzi, S. V., Fotiadou, A., Pissas, G., Kytoudis, K., Sounidaki, M., Ampatzis, G., Mertens, P. R., Liakopoulos, V., Eleftheriadis, T., Hadjigeorgiou, Georgios M, Santos, Mauro||, Zintzaras, E.   +15 more
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Consequences of diabetes and pre-diabetes and the role of biochemical parameters of carbohydrate metabolism for the functioning of the prefrontal cortex in obese patients

Frontiers in Bioscience-Landmark, 2022
Background: The role of executive functions (EF) is to maintain particular behaviours in order to achieve intended goals. EF are crucial in management of pre-diabetes, diabetes and obesity which are grievous diseases and can lead to severe complications.
Natalia Lesiewska, Alina Borkowska, Roman Junik, Anna Kamińska, Katarzyna Jaracz, Maciej Bieliński   +5 more
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Mitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole [PDF]

, 2011
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis.
Baharak Hooshiar Kashani, Antonella Cormio, TORRONI A., Pala M., MARRA M, Santoro Aurelia, Lancioni, Hovirag, ACHILLI A, Viola Grugni, Lancioni Hovirag, Grugni V., Cormio Antonella, Sirolla, Cristina, GRUGNI V, Anna Olivieri, Franceschi Claudio, Spazzafumo L., Cormio, Antonella, Testa Roberto, SIROLLA C, Torroni, Antonio, Ugo A. Perego, Hooshiar Kashani, Baharak, PEREGO UA, Boemi, Massimo, Grugni Viola, Olivieri Anna, Grugni, Viola, Hooshiar Kashani Baharak, Gadaleta Maria Nicola, Testa I., Bonfigli, Anna Rita, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Achilli A., Roberto Testa, Achilli A1, GANDINI F, TESTA I, Antonio Ceriello, Pala Maria, Gandini Francesca, TESTA R, Marra M., Spazzafumo, Liana, Testa R., Testa, Roberto, Semino Ornella, Marra, Maurizio, Carossa Valeria, Anna Rita Bonfigli, Cormio A, SPAZZAFUMO L, Maria Pala, Olivieri A., Ivano Testa, Olivieri, Anna, BOEMI M, Marra Maurizio, Perego, Ugo A., SANTORO A, SEMINO O, Achilli Alessandro, HOOSHIAR KASHANI B, Boemi M., Spazzafumo Liana, Battaglia V., Hooshiar Kashani B., Testa, Ivano, Aurelia Santoro, Torroni Antonio, Ceriello, Antonio, Boemi Massimo, Massimo Boemi, Valeria Carossa, Bonfigli A. R., LANCIONI H, Gandini, Francesca, Sirolla Cristina, Battaglia Vincenza, Gadaleta, Maria Nicola, BATTAGLIA V, Sirolla C., Santoro, Aurelia, Bonfigli Anna Rita, Gadaleta M. N., Ceriello A., Carossa, Valeria, CAROSSA V, Pala, Maria, FRANCESCHI C, Semino O., Ceriello Antonio, Ugo A Perego, Antonio Torroni, Maria Nicola Gadaleta, Testa Ivano, Perego U. A., BONFIGLI AR, Ornella Semino, Franceschi, Claudio, Maurizio Marra, Hovirag Lancioni, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, CERIELLO A, GADALETA MN, Francesca Gandini, PALA M, Carossa V., Cormio A., Lancioni H., OLIVIERI A, Perego Ugo A., Alessandro Achilli, Claudio Franceschi, Gandini F., Cristina Sirolla, Liana Spazzafumo   +119 more
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Prevalence of Vitamin D Deficiency Between Type 2 Diabetes Mellitus Patients and Non-Diabetics in the Arab Gulf

Diabetes, Metabolic Syndrome and Obesity, 2022
Muhammed Hassan Nasr,1 Bassam Abdul Rasool Hassan,2 Noordin Othman,3 Mahmathi Karuppannan,4 Noorizan binti Abdulaziz,5 Ali Haider Mohammed,2,6 Mohammed Ahmed Alsarani,7 Mohammed Husain Eskembaji,7 Abdelmannan Mohamed Aman,8 Gamil Othman9 1Clinical ...
Nasr MH, Hassan BAR, Othman N, Karuppannan M, Abdulaziz N, Mohammed AH, Alsarani MA, Eskembaji MH, Aman AM, Othman G   +9 more
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SP prevents T2DM complications by immunomodulation [PDF]

Scientific Reports, 2020
AbstractType 2 diabetic mellitus (T2DM) is characterized by systemic inflammation and insulin resistance due to obesity, and this leads to critical complications, including retinopathy and nephropathy. This study explored the therapeutic effect of substance-p (SP), a neuropeptide, on T2DM progression and its complications. To examine whether SP affects
Baek, Sang-Min, Kim, Kiyoung, Kim, Suna, Son, Youngsook, Hong, Hyun Sook, Yu, Seung-Young   +5 more
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Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2021
Amani MT Gusti,1,2 Safaa Y Qusti,1 Suhad M Bahijri,3,4 Eman A Toraih,5,6 Samia Bokhari,7 Sami M Attallah,8,9 Abdulwahab Alzahrani,10 Wafaa MA Alshehri,11 Hawazin Alotaibi,12 Manal S Fawzy13,14 1Department of Biochemistry, Faculty of Science, King ...
Gusti AMT, Qusti SY, Bahijri SM, Toraih EA, Bokhari S, Attallah SM, Alzahrani A, Alshehri WMA, Alotaibi H, Fawzy MS   +9 more
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A Versatile Model of Microfluidic Perifusion System for the Evaluation of C-Peptide Secretion Profiles: Comparison Between Human Pancreatic Islets and HLSC-Derived Islet-Like Structures

Biomedicines, 2020
A robust and easy-to-use tool for the ex vivo dynamic evaluation of pancreatic islet (PI) function is essential for further development of novel cell-based therapeutic approaches to treating diabetes.
Yonathan Gomez, Victor Navarro-Tableros, Ciro Tetta, Giovanni Camussi, Maria Felice Brizzi   +4 more
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T2DM/CKD genetic risk scores and the progression of diabetic kidney disease in T2DM subjects

Gene, 2023
Abstract This study explored the predictive value of genetic risk scores (GRS) for diabetic kidney disease (DKD) progression, Major Cardiovascular Events (MCVE), and All-Cause Mortality (ACM) in type 2 diabetes mellitus (T2DM) patients. We assessed 30 T2DM and CKD GWAS-derived single nucleotide polymorphisms (SNPs) in 400 Central European ...
David Galuška, Lukáš Pácal, Katarína Chalásová, Petra Divácká, Jitka Řehořová, Jan Svojanovský, Jaroslav A. Hubáček, Věra Lánská, Kateřina Kaňková   +8 more
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Reversal and Remission of T2DM – An Update for Practitioners

Vascular Health and Risk Management, 2022
Over the past 50 years, many countries around the world have faced an unchecked pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has done very little to check its growth, the pandemic of diabesity now threatens to make health-care systems economically more difficult for governments and individuals to manage within ...
Lina Shibib, Mo Al-Qaisi, Ahmed Ahmed, Alexander D Miras, David Nott, Marc Pelling, Stephen E Greenwald, Nicola Guess   +7 more
openaire   +4 more sources