Results 191 to 200 of about 17,578 (215)

Salmonella T3SS-2 Virulence Enhances Gut-Luminal Colonization by Enabling Chemotaxis-Dependent Exploitation of Intestinal Inflammation [PDF]

Cell Reports
Salmonella Typhimurium (S.Tm) utilizes the chemotaxis receptor Tsr to exploit gut inflammation. However, the characteristics of this exploitation and the mechanism(s) employed by the pathogen to circumvent antimicrobial effects of inflammation are poorly
Erik Bakkeren, Jakob Zimmermann, Mikael E Sellin   +2 more
exaly   +3 more sources

Structural Basis of Eukaryotic Cell Targeting by Type III Secretion System (T3SS) Effectors

Research in Microbiology, 2013
International audienceType III secretion systems (T3SS) are macromolecular complexes that translocate a wide number of effector proteins into eukaryotic host cells.
Andréa Dessen, Tommaso Tosi, Alexander Pflug   +2 more
exaly   +1 more source

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Modulation of Host Cell Processes by T3SS Effectors

2018
Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to ...
Shenoy, AR, Furniss, RCD, Goddard, PJ, Clements, A   +3 more
openaire   +3 more sources

Pore Formation by T3SS Translocators: Liposome Leakage Assay

2012
Gram-negative bacteria utilize a dedicated membrane-embedded apparatus, the type III secretion system (T3SS), to inject proteins into host cells. The passage of the proteins across the target membrane is accomplished by a proteinaceous pore-the translocon-formed within the host-cell cytoplasmic membrane.
Faudry, Eric, Perdu, Caroline, Attree, Ina   +2 more
openaire   +2 more sources

Towards capture of dynamic assembly and action of the T3SS at near atomic resolution

Current Opinion in Structural Biology, 2020
The T3SS is a syringe-shaped nanomachine essential for the progression of many Gram-negative bacterial infections including plague, typhoid fever, and dysentery. It spans both bacterial membranes and that of the host allowing delivery of proteins that modulate cell function to aid bacterial survival.
Jinhong Hu, Liam J Worrall, Natalie CJ Strynadka   +2 more
openaire   +2 more sources

Balanced Role of T3SS and T6SS in Contribution to the Full Virulence of Edwardsiella piscicida

Fish and Shellfish Immunology, 2019
Edwardsiella piscicida is an important pathogen that infects a wide range of hosts, from fish to human. Its infection leads to extensive losses in a diverse array of commercially important fish, like Japanese flounder, turbot, and tilapia. During the infection, type III secretion system (T3SS) and type VI secretion system (T6SS) of E.
Dahai Yang, Lingzhi Zhang, Qin Liu
exaly   +3 more sources

Overexpression of T3SS translocation signals in Salmonella causes delayed attenuation

Infection and Immunity
ABSTRACT Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously engineered Salmonella enterica serovar Typhimurium to overexpress the secretion signal of the type 3 secretion ...
Coers, Jörn, Abele, Taylor J., Larson, Heather N., Bryan, Alexia K., Miao, Edward A., Billman, Zachary P., Harvest, Carissa K.   +6 more
openaire   +2 more sources

Genome Analysis Identifies a Novel Type III Secretion System (T3SS) Category in Vibrio Species

Microorganisms, 2023
Tetsuya Hayashi, Masanori Arita, Shigeaki Matsuda   +2 more
exaly  

Novel Ethyl-3-Aryl-2-Nitroacrylate Derivatives as Potential T3SS Inhibitors Against Xanthomonas oryzae pv. Oryzae on Rice

Journal of Agricultural and Food Chemistry, 2023
Zi-Ning Cui
exaly  

The T3SS translocon in biofilm formation

Nature Reviews Microbiology, 2014
openaire   +1 more source