Results 31 to 40 of about 12,333 (188)

Regulation of T3SS synthesis, assembly and secretion in Pseudomonas aeruginosa

Archives of Microbiology, 2022
AbstractT3SS is an important virulence factor of Pseudomonas aeruginosa and has a central role in the infection process. However, the functional regulation of the T3SS by environmental signals is poorly understood. In our lab, we use fluorescence microscopy to study protein kinetics in real-time in live cells. In P.
H. M. Selim, Tharwat Radwan, Amany M. Reyad   +2 more
openaire   +2 more sources

Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing [PDF]

Wound Repair and Regeneration, 2015
ABSTRACTDiabetic foot ulcers are responsible for more hospitalizations than any other complication of diabetes. Bacterial infection is recognized as an important factor associated with impaired healing in diabetic ulcers. Pseudomonas aeruginosa is the most frequently detected Gram‐negative pathogen in diabetic ulcers. P.
Josef, Goldufsky, Stephen J, Wood, Vijayakumar, Jayaraman, Omar, Majdobeh, Lin, Chen, Shanshan, Qin, Chunxiang, Zhang, Luisa A, DiPietro, Sasha H, Shafikhani   +8 more
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Expression of the Type III Secretion System Genes in Epiphytic Erwinia amylovora Cells on Apple Stigmas Benefits Endophytic Infection at the Hypanthium

Molecular Plant-Microbe Interactions, 2021
Erwinia amylovora causes fire blight on rosaceous plants. One of the major entry points of E. amylovora into hosts is flowers, where E. amylovora proliferates epiphytically on stigmatic and hypanthium surfaces and, subsequently, causes endophytic ...
Zhouqi Cui, Regan B. Huntley, Neil P Schultes, Kaleem U. Kakar, Ching-Hong Yang, Quan Zeng   +5 more
doaj   +1 more source

Novel Insight of Transcription Factor PtrA on Pathogenicity and Carbapenems Resistance in Pseudomonas aeruginosa

Infection and Drug Resistance, 2022
Ying Zhang,1,* Lingbo Wang,1,* Liqiong Chen,2 Peiwu Zhu,1 Na Huang,1 Tao Chen,1 Lijiang Chen,1 Zhongyong Wang,1 Wenli Liao,1 Jianming Cao,2 Tieli Zhou1 1Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical ...
Zhang Y, Wang L, Chen L, Zhu P, Huang N, Chen T, Chen L, Wang Z, Liao W, Cao J, Zhou T   +10 more
doaj  

Dynamic relocalization of cytosolic type III secretion system components prevents premature protein secretion at low external pH

Nature Communications, 2021
Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS ...
Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold   +10 more
doaj   +1 more source

Spermidine Is an Intercellular Signal Modulating T3SS Expression in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
Type III secretion system (T3SS) is one of the pivotal virulence factors of Pseudomonas aeruginosa responsible for evading phagocytosis, and secreting and translocating effectors into host cells. Previous studies underline the complicated and elaborate regulatory mechanisms of T3SS for the accurate, fast, and ...
Qiqi Lin, Huishan Wang, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Guohui Yu, Zeling Xu, Ping Cheng, Zhibin Liang, Lian-Hui Zhang   +9 more
openaire   +3 more sources

Identification of VPA1327 (vopT) as a Novel Genetic Marker for Detecting Pathogenic Vibrio parahaemolyticus

Journal of Pure and Applied Microbiology, 2018
Vibrio parahaemolyticus is a Gram-negative bacterium that is ubiquitous in marine and estuarine environments. The pathogenic strains can cause foodborne gastroenteritis especially when raw or undercooked seafood contaminated with pathogenic V ...
Phatcharaporn Chiawwit, Monchanok Boonyahong, Unchana Thawornwan, Potjanee Srimanote, Pongsri Tongtawe   +4 more
doaj   +1 more source

Identification of specific sequence motif of YopN of Yersinia pseudotuberculosis required for systemic infection

Virulence, 2019
Type III secretion systems (T3SSs) are tightly regulated key virulence mechanisms shared by many Gram-negative pathogens. YopN, one of the substrates, is also crucial in regulation of expression, secretion and activation of the T3SS of pathogenic ...
Sarp Bamyaci, Roland Nordfelth, Åke Forsberg   +2 more
doaj   +1 more source

An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Frontiers in Cellular and Infection Microbiology, 2018
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with
Jessica M. Morgan, Hanh N. Lam, Jocelyn Delgado, Justin Luu, Sina Mohammadi, Ralph R. Isberg, Helen Wang, Victoria Auerbuch   +7 more
doaj   +1 more source

Generation and Characterization of a scFv Antibody Against T3SS Needle of Vibrio parahaemolyticus [PDF]

Indian Journal of Microbiology, 2013
Vibrio parahaemolyticus, a halophilic gram-negative bacterium, is a food-borne pathogen that largely inhabits marine and estuarine environments, and poses a serious threat to human and animal health all over the world. The hollow "needle" channel, a specific assemble of T3SS which exists in most of gram-negative bacteria, plays a key role in the ...
Rongzhi Wang, Fang Sui, Shuangshuang Xiang, Sumei Ling, Jun Yuan, Shihua Wang   +5 more
openalex   +4 more sources