Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components [PDF]
Biomolecules, 2021 The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable
Julia A. Hotinger +2 more
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Building a secreting nanomachine: a structural overview of the T3SS. [PDF]
Current Opinion in Structural Biology, 2014 To fulfill complex biological tasks, such as locomotion and protein translocation, bacteria assemble macromolecular nanomachines. One such nanodevice, the type III secretion system (T3SS), has evolved to provide a means of transporting proteins from the ...
Johnson, Steven +7 more
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HrpS Is a Global Regulator on Type III Secretion System (T3SS) and Non-T3SS Genes in Pseudomonas savastanoi pv. phaseolicola [PDF]
Molecular Plant-Microbe Interactions®, 2018 The type III secretion system (T3SS) is the main machinery for Pseudomonas savastanoi and other gram-negative bacteria to invade plant cells. HrpR and HrpS form a hetero-hexamer, which activates the expression of HrpL, which induces all T3SS genes by ...
Tingting Wang +11 more
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Evading plant immunity: feedback control of the T3SS in Pseudomonas syringae [PDF]
Microbial Cell, 2017 Microbes are responsible for over 10% of the global yield losses in staple crops such as wheat, rice, and maize. Understanding the decision-making strategies that enable bacterial plant pathogens to evade the host immune system and cause disease is ...
Christopher Waite +10 more
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Polynucleotide Phosphorylase and the T3SS
, 2007 Low temperatures as well as encounters with host phagocytes are two stresses that have been relatively well studied in many species of bacteria. The exoribonuclease polynucleotide phosphorylase (PNPase) has previously been shown to be required by several
Schesser, Kurt +3 more
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Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors
Trends in Microbiology, 2018 International audienceMicrobial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection.
Phalipon, Armelle +5 more
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A nonstop thrill ride from genes to the assembly of the T3SS injectisome
Nature Communications, 2023 The type three secretion system (T3SS) is a membrane-anchored nano-machine utilized by many pathogenic bacteria to inject effector proteins and thus take control of host cells. In a recent article, Kaval et al.
Sharanya Namboodiri, Itzhak Fishov
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Beyond pathogenicity: applications of the type III secretion system (T3SS) of Pseudomonas aeruginosa [PDF]
Frontiers in MicrobiologyThe Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system (T3SS) as a pivotal factor in facilitating the injection of effector proteins into host cells.
Tianqi Su +5 more
doaj +2 more sources
Unprecedented Protein Divergence Within a T3SS Family [PDF]
SSRN Electronic Journal, 2021 Selection pressure drives rapid emergence of antibiotic resistance mechanisms promoting searches for therapeutic targets in bacterial processes needed for virulence, not viability, which include the Type Three Secretion System (T3SS).
Azzeldin Madkour +3 more
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An intra-bacterial activity for a T3SS effector [PDF]
Scientific Reports, 2020 Abstract Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins into host cells. A subset of these injected protein ‘effectors’ are enzymes that inhibit the function of host proteins by catalyzing the addition of unusual post ...
El Qaidi, S +5 more
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