Building a secreting nanomachine: a structural overview of the T3SS
Current Opinion in Structural Biology, 2014 To fulfill complex biological tasks, such as locomotion and protein translocation, bacteria assemble macromolecular nanomachines. One such nanodevice, the type III secretion system (T3SS), has evolved to provide a means of transporting proteins from the bacterial cytoplasm across the periplasmic and extracellular spaces.
Abrusci, P. +3 more
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Evading plant immunity: feedback control of the T3SS in Pseudomonas syringae [PDF]
Microbial Cell, 2017 Microbes are responsible for over 10% of the global yield losses in staple crops such as wheat, rice, and maize. Understanding the decision-making strategies that enable bacterial plant pathogens to evade the host immune system and cause disease is essential for managing their ever growing threat to food security.
Waite, C +4 more
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The T3SS of Shigella: Expression, Structure, Function, and Role in Vacuole Escape [PDF]
Microorganisms, 2020 Shigella spp. are one of the leading causes of infectious diarrheal diseases. They are Escherichia coli pathovars that are characterized by the harboring of a large plasmid that encodes most virulence genes, including a type III secretion system (T3SS).
Waad Bajunaid +7 more
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Functional and computational analysis of amino acid patterns predictive of type III secretion system substrates in Pseudomonas syringae. [PDF]
PLoS ONE, 2012 Bacterial type III secretion systems (T3SSs) deliver proteins called effectors into eukaryotic cells. Although N-terminal amino acid sequences are required for translocation, the mechanism of substrate recognition by the T3SS is unknown.
Lisa M Schechter +4 more
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The Yersinia enterocolitica type 3 secretion system (T3SS) as toolbox for studying the cell biological effects of bacterial Rho GTPase modulating T3SS effector proteins [PDF]
Cellular Microbiology, 2011 The bacterial effector proteins IpgB(1) and IpgB(2) of Shigella and Map of Escherichia coli activate the Rho GTPases Rac1, RhoA and Cdc42, respectively, whereas YopE and YopT of Yersinia inhibit these Rho family GTPases. We established a Yersinia toolbox which allows to study the cellular effects of these effectors in different combinations in the ...
Stefan, Wölke +2 more
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ExsE Is a Negative Regulator for T3SS Gene Expression in Vibrio alginolyticus [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 Type III secretion systems (T3SSs) contribute to microbial pathogenesis of Vibrio species, but the regulatory mechanisms are complex. We determined if the classic ExsACDE protein-protein regulatory model from Pseudomonas aeruginosa applies to Vibrio alginolyticus. Deletion mutants in V.
Jinxin Liu +9 more
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Type III secretion system genes of Dickeya dadantii 3937 are induced by plant phenolic acids. [PDF]
PLoS ONE, 2008 Dickeya dadantii is a broad-host range phytopathogen. D. dadantii 3937 (Ech3937) possesses a type III secretion system (T3SS), a major virulence factor secretion system in many gram-negative pathogens of plants and animals.
Shihui Yang +5 more
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Molecular Mechanisms of Salmonella Effector Proteins: A Comprehensive Review
Infection and Drug Resistance, 2020 Taher Azimi,1,2 Maryam Zamirnasta,3 Mahmood Alizadeh Sani,4,5 Mohammad Mehdi Soltan Dallal,6 Ahmad Nasser3,6,7 1Pediatric Infections Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Students Scientific Research Center ...
Azimi T +4 more
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Frontiers in Microbiology, 2017 Previously, we isolated several genes that potentially affected the expression of type III secretion system (T3SS) in Ralstonia solanacearum OE1-1. Here, we focused on the rsp0316, which encodes a putative 2-nitropropane dioxygenase (hereafter designated
Weiqi Zhang +6 more
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NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa
Frontiers in Microbiology, 2019 The type III secretion system (T3SS) plays an important role in the pathogenesis of Pseudomonas aeruginosa. Expression of the T3SS is controlled under a complicate regulatory network.
Yongxin Jin +10 more
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